Matches in SemOpenAlex for { <https://semopenalex.org/work/W4367601315> ?p ?o ?g. }
- W4367601315 abstract "The congenital short QT syndrome (SQTS) is a rare condition characterized by abbreviated rate-corrected QT (QTc) intervals on the electrocardiogram and by increased susceptibility to both atrial and ventricular arrhythmias and sudden death. Although mutations to multiple genes have been implicated in the SQTS, evidence of causality is particularly strong for the first three (SQT1-3) variants: these result from gain-of-function mutations in genes that encode K+ channel subunits responsible, respectively, for the IKr, IKs and IK1 cardiac potassium currents. This article reviews evidence for the impact of SQT1-3 missense potassium channel gene mutations on the electrophysiological properties of IKr, IKs and IK1 and of the links between these changes and arrhythmia susceptibility. Data from experimental and simulation studies and future directions for research in this field are considered. This article is part of the theme issue 'The heartbeat: its molecular basis and physiological mechanisms'." @default.
- W4367601315 created "2023-05-02" @default.
- W4367601315 creator A5031201319 @default.
- W4367601315 creator A5036407367 @default.
- W4367601315 creator A5037737415 @default.
- W4367601315 creator A5043170950 @default.
- W4367601315 creator A5043271142 @default.
- W4367601315 creator A5046626341 @default.
- W4367601315 creator A5078431481 @default.
- W4367601315 date "2023-05-01" @default.
- W4367601315 modified "2023-10-15" @default.
- W4367601315 title "Pro-arrhythmic effects of gain-of-function potassium channel mutations in the short QT syndrome" @default.
- W4367601315 cites W1524713415 @default.
- W4367601315 cites W1550922337 @default.
- W4367601315 cites W1565649759 @default.
- W4367601315 cites W1809798419 @default.
- W4367601315 cites W1879679015 @default.
- W4367601315 cites W1962981259 @default.
- W4367601315 cites W1965633790 @default.
- W4367601315 cites W1967019376 @default.
- W4367601315 cites W1968098810 @default.
- W4367601315 cites W1969060286 @default.
- W4367601315 cites W1974081708 @default.
- W4367601315 cites W1984090294 @default.
- W4367601315 cites W1985718987 @default.
- W4367601315 cites W1989598680 @default.
- W4367601315 cites W1989943515 @default.
- W4367601315 cites W1990128791 @default.
- W4367601315 cites W1992387760 @default.
- W4367601315 cites W1993012529 @default.
- W4367601315 cites W1994107787 @default.
- W4367601315 cites W2005591721 @default.
- W4367601315 cites W2006047900 @default.
- W4367601315 cites W2007048322 @default.
- W4367601315 cites W2007825638 @default.
- W4367601315 cites W2012606767 @default.
- W4367601315 cites W2012824002 @default.
- W4367601315 cites W2018256150 @default.
- W4367601315 cites W2021438486 @default.
- W4367601315 cites W2022583158 @default.
- W4367601315 cites W2025044916 @default.
- W4367601315 cites W2025470533 @default.
- W4367601315 cites W2026373503 @default.
- W4367601315 cites W2029476720 @default.
- W4367601315 cites W2035498382 @default.
- W4367601315 cites W2036860058 @default.
- W4367601315 cites W2037832050 @default.
- W4367601315 cites W2039230012 @default.
- W4367601315 cites W2040826404 @default.
- W4367601315 cites W2041110681 @default.
- W4367601315 cites W2042832519 @default.
- W4367601315 cites W2043306423 @default.
- W4367601315 cites W2044024203 @default.
- W4367601315 cites W2045548568 @default.
- W4367601315 cites W2046955247 @default.
- W4367601315 cites W2046995007 @default.
- W4367601315 cites W2049031993 @default.
- W4367601315 cites W2050841780 @default.
- W4367601315 cites W2051221190 @default.
- W4367601315 cites W2051248612 @default.
- W4367601315 cites W2055038470 @default.
- W4367601315 cites W2057323550 @default.
- W4367601315 cites W2058240154 @default.
- W4367601315 cites W2059549625 @default.
- W4367601315 cites W2066214870 @default.
- W4367601315 cites W2066742955 @default.
- W4367601315 cites W2068293171 @default.
- W4367601315 cites W2069545616 @default.
- W4367601315 cites W2070166705 @default.
- W4367601315 cites W2072672465 @default.
- W4367601315 cites W2077203000 @default.
- W4367601315 cites W2080355249 @default.
- W4367601315 cites W2082143829 @default.
- W4367601315 cites W2085048839 @default.
- W4367601315 cites W2089861793 @default.
- W4367601315 cites W2092718904 @default.
- W4367601315 cites W2100078256 @default.
- W4367601315 cites W2102313919 @default.
- W4367601315 cites W2102516854 @default.
- W4367601315 cites W2103213103 @default.
- W4367601315 cites W2110864963 @default.
- W4367601315 cites W2120263248 @default.
- W4367601315 cites W2123892496 @default.
- W4367601315 cites W2124148610 @default.
- W4367601315 cites W2124310785 @default.
- W4367601315 cites W2125553912 @default.
- W4367601315 cites W2127256299 @default.
- W4367601315 cites W2129393568 @default.
- W4367601315 cites W2133315076 @default.
- W4367601315 cites W2136755991 @default.
- W4367601315 cites W2139222531 @default.
- W4367601315 cites W2141803433 @default.
- W4367601315 cites W2142314977 @default.
- W4367601315 cites W2146438418 @default.
- W4367601315 cites W2148764498 @default.
- W4367601315 cites W2152513067 @default.
- W4367601315 cites W2156609021 @default.
- W4367601315 cites W2158205763 @default.
- W4367601315 cites W2159561758 @default.
- W4367601315 cites W2160845018 @default.