Matches in SemOpenAlex for { <https://semopenalex.org/work/W4367601810> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W4367601810 endingPage "1445" @default.
- W4367601810 startingPage "1440" @default.
- W4367601810 abstract "Abstract Background Glecaprevir and Pibrentasvir (G/P) determine high rates of sustained virological response (SVR) with optimal safety profile in patients with chronic hepatitis C virus (HCV) infection. The efficacy and safety of G/P in Caucasian patients aged 75 years and older have not been widely analysed. Methods This is a retrospective multicentre real‐world study enrolling all consecutive patients 75 years and older who received G/P between October 2017 and January 2022 at five referral centres in Italy. SVR was analysed by intention‐to‐treat (ITT) and per‐protocol analyses (PP). Results A total of 570 patients met the inclusion criteria and were analysed: mean age was 80 (75–97) years, 356 (62%) were females, 52% (298/570) had HCV‐1, 44% (252/570) had HCV‐2 and 137 (24%) patients had liver cirrhosis. Four hundred and sixty‐three (81%) patients were taking at least one concomitant drug, with 144 (25%) taking ≥5 concomitant drugs. G/P was given for 8 weeks in 488 patients (86%). During treatment, 48 patients (8%) reported side effects, with 10 (2%) patients discontinuing treatment prematurely. Two patients developed treatment‐unrelated serious adverse events. Overall, the SVR rate was 97.9% (558/570) by ITT analysis and 99.6% (558/560) by PP analysis. SVR rates remained consistently high among subgroup analysis stratified by genotype, treatment duration, fibrosis stage and concomitant medications. Conclusions Treatment with G/P achieved 97.9% SVR rates in HCV patients older than 75 years of age. Safety was optimal with only 2% of patients discontinuing early." @default.
- W4367601810 created "2023-05-02" @default.
- W4367601810 creator A5000548065 @default.
- W4367601810 creator A5013984238 @default.
- W4367601810 creator A5025454109 @default.
- W4367601810 creator A5027631947 @default.
- W4367601810 creator A5040002369 @default.
- W4367601810 creator A5040774689 @default.
- W4367601810 creator A5047428835 @default.
- W4367601810 creator A5048901003 @default.
- W4367601810 creator A5055005038 @default.
- W4367601810 creator A5061230265 @default.
- W4367601810 creator A5069060952 @default.
- W4367601810 creator A5085311921 @default.
- W4367601810 creator A5091326593 @default.
- W4367601810 date "2023-04-30" @default.
- W4367601810 modified "2023-10-12" @default.
- W4367601810 title "Glecaprevir/Pibrentasvir is safe and effective in Italian patients with chronic hepatitis C aged 75 years or older: A multicentre study" @default.
- W4367601810 cites W2015740979 @default.
- W4367601810 cites W2471240922 @default.
- W4367601810 cites W2754868188 @default.
- W4367601810 cites W2790468436 @default.
- W4367601810 cites W2978744917 @default.
- W4367601810 cites W2996996849 @default.
- W4367601810 cites W3015083835 @default.
- W4367601810 cites W3049273641 @default.
- W4367601810 cites W3088020815 @default.
- W4367601810 cites W3090350690 @default.
- W4367601810 cites W3109461289 @default.
- W4367601810 cites W3125175018 @default.
- W4367601810 cites W3131386574 @default.
- W4367601810 cites W3154379680 @default.
- W4367601810 cites W3159219723 @default.
- W4367601810 cites W3165949597 @default.
- W4367601810 cites W3173694532 @default.
- W4367601810 cites W4200205158 @default.
- W4367601810 cites W4200473175 @default.
- W4367601810 cites W4212775035 @default.
- W4367601810 cites W4225142645 @default.
- W4367601810 cites W4280570876 @default.
- W4367601810 doi "https://doi.org/10.1111/liv.15599" @default.
- W4367601810 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37122194" @default.
- W4367601810 hasPublicationYear "2023" @default.
- W4367601810 type Work @default.
- W4367601810 citedByCount "0" @default.
- W4367601810 crossrefType "journal-article" @default.
- W4367601810 hasAuthorship W4367601810A5000548065 @default.
- W4367601810 hasAuthorship W4367601810A5013984238 @default.
- W4367601810 hasAuthorship W4367601810A5025454109 @default.
- W4367601810 hasAuthorship W4367601810A5027631947 @default.
- W4367601810 hasAuthorship W4367601810A5040002369 @default.
- W4367601810 hasAuthorship W4367601810A5040774689 @default.
- W4367601810 hasAuthorship W4367601810A5047428835 @default.
- W4367601810 hasAuthorship W4367601810A5048901003 @default.
- W4367601810 hasAuthorship W4367601810A5055005038 @default.
- W4367601810 hasAuthorship W4367601810A5061230265 @default.
- W4367601810 hasAuthorship W4367601810A5069060952 @default.
- W4367601810 hasAuthorship W4367601810A5085311921 @default.
- W4367601810 hasAuthorship W4367601810A5091326593 @default.
- W4367601810 hasConcept C126322002 @default.
- W4367601810 hasConcept C197934379 @default.
- W4367601810 hasConcept C203014093 @default.
- W4367601810 hasConcept C2522874641 @default.
- W4367601810 hasConcept C2776408679 @default.
- W4367601810 hasConcept C2776455275 @default.
- W4367601810 hasConcept C2777214474 @default.
- W4367601810 hasConcept C2779384505 @default.
- W4367601810 hasConcept C71924100 @default.
- W4367601810 hasConcept C90924648 @default.
- W4367601810 hasConceptScore W4367601810C126322002 @default.
- W4367601810 hasConceptScore W4367601810C197934379 @default.
- W4367601810 hasConceptScore W4367601810C203014093 @default.
- W4367601810 hasConceptScore W4367601810C2522874641 @default.
- W4367601810 hasConceptScore W4367601810C2776408679 @default.
- W4367601810 hasConceptScore W4367601810C2776455275 @default.
- W4367601810 hasConceptScore W4367601810C2777214474 @default.
- W4367601810 hasConceptScore W4367601810C2779384505 @default.
- W4367601810 hasConceptScore W4367601810C71924100 @default.
- W4367601810 hasConceptScore W4367601810C90924648 @default.
- W4367601810 hasIssue "7" @default.
- W4367601810 hasLocation W43676018101 @default.
- W4367601810 hasLocation W43676018102 @default.
- W4367601810 hasOpenAccess W4367601810 @default.
- W4367601810 hasPrimaryLocation W43676018101 @default.
- W4367601810 hasRelatedWork W1979664732 @default.
- W4367601810 hasRelatedWork W2047045739 @default.
- W4367601810 hasRelatedWork W2052290779 @default.
- W4367601810 hasRelatedWork W2107508210 @default.
- W4367601810 hasRelatedWork W2117027295 @default.
- W4367601810 hasRelatedWork W2130839534 @default.
- W4367601810 hasRelatedWork W2418235480 @default.
- W4367601810 hasRelatedWork W2762048449 @default.
- W4367601810 hasRelatedWork W2861307256 @default.
- W4367601810 hasRelatedWork W4255093297 @default.
- W4367601810 hasVolume "43" @default.
- W4367601810 isParatext "false" @default.
- W4367601810 isRetracted "false" @default.
- W4367601810 workType "article" @default.