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• W4367603993 endingPage "579" @default.
• W4367603993 startingPage "567" @default.
• W4367603993 abstract "Primary cilia are hair-like structures located on the surface of eukaryotic cells and regulate relevant function as photoreception, chemosensing, mechanosensing, and neuromodulation. Mutations in genes encoding ciliary proteins cause ciliopathies, with clinical manifestations that include nephropathy, cardiovascular, metabolic, and neurodevelopmental abnormalities. Primary cilia dysfunction has been associated with several hallmarks of aging, dysregulated inflammatory responses in peripheral tissues and in the brain, DNA damage response, proteostasis dysfunction, cell senescence, and malfunction of interneuronal circuits. Pharmacological manipulation of primary cilia may counteract age-associated diseases such as cancer, neurodegenerative, metabolic disorders and extend health lifespan. Primary cilia are specialized organelles that sense changes in extracellular milieu, and their malfunction is responsible for several disorders (ciliopathies). Increasing evidence shows that primary cilia regulate tissue and cellular aging related features, which led us to review the evidence on their role in potentiating and/or accelerating the aging process. Primary cilia malfunction is associated with some age-related disorders, from cancer to neurodegenerative and metabolic disorders. However, there is limited understanding of molecular pathways underlying primary cilia dysfunction, resulting in scarce ciliary-targeted therapies available. Here, we discuss the findings on primary cilia dysfunction as modulators of the health and aging hallmarks, and the pertinence of ciliary pharmacological targeting to promote healthy aging or treat age-related diseases. Primary cilia are specialized organelles that sense changes in extracellular milieu, and their malfunction is responsible for several disorders (ciliopathies). Increasing evidence shows that primary cilia regulate tissue and cellular aging related features, which led us to review the evidence on their role in potentiating and/or accelerating the aging process. Primary cilia malfunction is associated with some age-related disorders, from cancer to neurodegenerative and metabolic disorders. However, there is limited understanding of molecular pathways underlying primary cilia dysfunction, resulting in scarce ciliary-targeted therapies available. Here, we discuss the findings on primary cilia dysfunction as modulators of the health and aging hallmarks, and the pertinence of ciliary pharmacological targeting to promote healthy aging or treat age-related diseases. highly evolutionary conserved, self-degradative process of cellular components such as defective organelles (mitochondria and endoplasmic reticulum), long-lived, misfolded proteins and pathogens, through lysosomes. Important for energy homeostasis during development and in response to nutrient stress. dynamic process of the building of primary cilia, involving actin filaments, microtubules, and membrane remodeling to generate the signaling organelle. endogenous oscillations in physical, mental, and behavioral aspects during a 24-h cycle. Controls many physiological aspects, namely sleep, metabolism and immune system. genome editing technology that allows targeted gene editing by precisely cutting DNA, followed by endogenous DNA repair mechanisms. lipid-bilayer-delimited structures, secreted by a variety of cell types into the extracellular space, responsible for delivering proteins, metabolites, and nucleic acids to recipient cells. cell surface receptors, convert extracellular signals into intracellular signals through the interaction with G proteins in the plasma membrane. This interaction triggers the production of a variety of second messengers that modulate many cellular responses, including to hormones, neurotransmitters, and environmental stimuli. highly conserved evolutionary signaling pathway, transduction of signals from the cell membrane to the nucleus. Plays important roles in embryonic development, cellular proliferation, differentiation, and stem cell maintenance. cells derived from inner cell mass of blastocyst embryos; these cells are pluripotent with the potential to differentiate into any tissue of the human body. a rare, fatal, genetic condition that manifests early in childhood and causes premature aging. Progeria is caused by an autosomal dominant mutation in LMNA that produces aberrant farnesylation of lamin A protein, designated progerin. embryonic-stem-cell-like cells that have been reprogrammed from somatic cells into an embryonic-like pluripotent state, allowing the differentiation into any type of human cell. appetite suppressor hormone, released from the adipose tissue and acts in the hypothalamus, regulates food intake, body mass and reproductive function. class of materials that include particulate substances with less than 100 nM of dimension, engineered to improve the stability of encapsulated cargos, allowing transport across membranes. transcription factor of the antioxidant response, responsible for regulating the expression of antioxidant enzymes and other genes related to redox homeostasis. cell surface receptors, mediate cell-to-cell communication and control a wide range of complex biological functions, including cell growth, motility, differentiation, and metabolism. intracellular protein degradation mechanism system in eukaryotes for the clearance of short-lived, damaged, and misfolded proteins in the nucleus and cytoplasm. Comprises two steps: ubiquitylation of the target proteins followed by proteasomal degradation. evolutionary conserved pathway, regulates crucial aspects of cell fate determination, cell polarity and patterning during embryonic development, adult tissue homeostasis and regeneration of tissues and organs." @default.
• W4367603993 created "2023-05-02" @default.
• W4367603993 creator A5022654558 @default.
• W4367603993 creator A5023039989 @default.
• W4367603993 date "2023-07-01" @default.
• W4367603993 modified "2023-10-16" @default.
• W4367603993 title "Primary cilia shape hallmarks of health and aging" @default.
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