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- W4367608489 abstract "Chronic environmental exposure to polychlorinated biphenyls (PCBs) is associated with non-alcoholic fatty liver disease (NAFLD) and exacerbated by a high fat diet (HFD). Here, chronic (34 wks.) exposure of low fat diet (LFD)-fed male mice to Aroclor 1260 (Ar1260), a non-dioxin-like (NDL) mixture of PCBs, resulted in steatohepatitis and NAFLD. Twelve hepatic RNA modifications were altered with Ar1260 exposure including reduced abundance of 2′-O-methyladenosine (Am) and N(6)-methyladenosine (m6A), in contrast to increased Am in the livers of HFD-fed, Ar1260-exposed mice reported previously. Differences in 13 RNA modifications between LFD- and HFD- fed mice, suggest that diet regulates the liver epitranscriptome. Integrated network analysis of epitranscriptomic modifications identified a NRF2 (Nfe2l2) pathway in the chronic, LFD, Ar1260-exposed livers and an NFATC4 (Nfatc4) pathway for LFD- vs. HFD-fed mice. Changes in protein abundance were validated. The results demonstrate that diet and Ar1260 exposure alter the liver epitranscriptome in pathways associated with NAFLD." @default.
- W4367608489 created "2023-05-02" @default.
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- W4367608489 date "2023-06-01" @default.
- W4367608489 modified "2023-09-27" @default.
- W4367608489 title "Disruption of the mouse liver epitranscriptome by long-term aroclor 1260 exposure" @default.
- W4367608489 cites W1513584599 @default.
- W4367608489 cites W1554837601 @default.
- W4367608489 cites W1809679012 @default.
- W4367608489 cites W1974253904 @default.
- W4367608489 cites W1980739328 @default.
- W4367608489 cites W1985026615 @default.
- W4367608489 cites W1999275343 @default.
- W4367608489 cites W2013328321 @default.
- W4367608489 cites W2015861974 @default.
- W4367608489 cites W2018868898 @default.
- W4367608489 cites W2028819432 @default.
- W4367608489 cites W2033364356 @default.
- W4367608489 cites W2035676834 @default.
- W4367608489 cites W2052326665 @default.
- W4367608489 cites W2067740038 @default.
- W4367608489 cites W2080138200 @default.
- W4367608489 cites W2082283120 @default.
- W4367608489 cites W2088264214 @default.
- W4367608489 cites W2096618952 @default.
- W4367608489 cites W2100022630 @default.
- W4367608489 cites W2100086304 @default.
- W4367608489 cites W2104564665 @default.
- W4367608489 cites W2113653640 @default.
- W4367608489 cites W2127860658 @default.
- W4367608489 cites W2131770490 @default.
- W4367608489 cites W2134526812 @default.
- W4367608489 cites W2141386840 @default.
- W4367608489 cites W2145812739 @default.
- W4367608489 cites W2152311269 @default.
- W4367608489 cites W2164412863 @default.
- W4367608489 cites W2169300811 @default.
- W4367608489 cites W2169456326 @default.
- W4367608489 cites W2179438025 @default.
- W4367608489 cites W2252643587 @default.
- W4367608489 cites W2264920865 @default.
- W4367608489 cites W2276606325 @default.
- W4367608489 cites W2293546533 @default.
- W4367608489 cites W2300552860 @default.
- W4367608489 cites W2331611239 @default.
- W4367608489 cites W2432150382 @default.
- W4367608489 cites W2528415436 @default.
- W4367608489 cites W2535762306 @default.
- W4367608489 cites W2557904026 @default.
- W4367608489 cites W2560066690 @default.
- W4367608489 cites W2589855162 @default.
- W4367608489 cites W2610162195 @default.
- W4367608489 cites W2627064270 @default.
- W4367608489 cites W2758966449 @default.
- W4367608489 cites W2765236538 @default.
- W4367608489 cites W2768377421 @default.
- W4367608489 cites W2790475021 @default.
- W4367608489 cites W2804780316 @default.
- W4367608489 cites W2807259057 @default.
- W4367608489 cites W2807768256 @default.
- W4367608489 cites W2809230835 @default.
- W4367608489 cites W2886338523 @default.
- W4367608489 cites W2897158734 @default.
- W4367608489 cites W2902501977 @default.
- W4367608489 cites W2906608530 @default.
- W4367608489 cites W2916084686 @default.
- W4367608489 cites W2941599200 @default.
- W4367608489 cites W2942214653 @default.
- W4367608489 cites W2942949465 @default.
- W4367608489 cites W2947374360 @default.
- W4367608489 cites W2958877445 @default.
- W4367608489 cites W2970645663 @default.
- W4367608489 cites W2972933339 @default.
- W4367608489 cites W2980671377 @default.
- W4367608489 cites W2999670862 @default.
- W4367608489 cites W3000611066 @default.
- W4367608489 cites W3003360804 @default.
- W4367608489 cites W3012058091 @default.
- W4367608489 cites W3013299922 @default.
- W4367608489 cites W3017465316 @default.
- W4367608489 cites W3034162475 @default.
- W4367608489 cites W3037147139 @default.
- W4367608489 cites W3039873626 @default.
- W4367608489 cites W3043168565 @default.