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- W4367623786 abstract "Alzheimer's disease (AD) is a progressive neurodegenerative disease and linked to abnormal deposition of amyloid-β (Aβ), neurofibrillary tangles (NFTs), synaptic dysfunction, and neuroinflammation. Despite significant progress in unravelling the pathogenesis of AD, currently main therapeutic interventions is limited to symptomatic alleviation. Methylprednisolone (MP), a synthetic glucocorticoid, is recognized for its extensive anti-inflammatory properties. Our study assessed the neuroprotective effect of MP (25 mg/kg) administration to an Aβ1-42-induced AD mouse model. Our findings demonstrate that MP treatment can ameliorate cognitive impairment in Aβ1-42-induced AD mice and suppress microglial activation in the cortex and hippocampus. RNA-Sequencing analysis reveals that MP ultimately rescues cognitive dysfunction through improving the synapse function and inhibiting the immune and inflammatory processes. Our study suggests that MP could be a promising drug alternative for the treatment of AD, either alone or in combination with other existing drugs." @default.
- W4367623786 created "2023-05-02" @default.
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- W4367623786 date "2023-05-01" @default.
- W4367623786 modified "2023-10-06" @default.
- W4367623786 title "Methylprednisolone alleviates cognitive functions through the regulation of neuroinflammation in Alzheimer’s disease" @default.
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- W4367623786 doi "https://doi.org/10.3389/fimmu.2023.1192940" @default.
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