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- W4367623897 abstract "Hardystonite-based (HT) bioceramic foams were easily obtained via thermal treatment of silicone resins and reactive oxide fillers in air. By using a commercial silicone, incorporating strontium oxide and magnesium oxide precursors (as well as CaO and ZnO), and treating it at 1100 °C, a complex solid solution (Ca1.4Sr0.6Zn0.85Mg0.15Si2O7) that has superior biocompatibility and bioactivity properties compared to pure hardystonite (Ca2ZnSi2O7) can be obtained. Proteolytic-resistant adhesive peptide mapped on vitronectin (D2HVP), was selectively grafted to Sr/Mg-doped HT foams using two different strategies. Unfortunately, the first method (via protected peptide) was unsuitable for acid-sensitive materials such as Sr/Mg-doped HT, resulting in the release of cytotoxic levels of Zinc over time, with consequent negative cellular response. To overcome this unexpected result, a novel functionalization strategy requiring aqueous solution and mild conditions was designed. Sr/Mg-doped HT functionalized with this second strategy (via aldehyde peptide) showed a dramatic increase in human osteoblast proliferation at 6 days compared to only silanized or non-functionalized samples. Furthermore, we demonstrated that the functionalization treatment does not induce any cytotoxicity. Functionalized foams enhanced mRNA-specific transcript levels coding IBSP, VTN, RUNX2, and SPP1 at 2 days post-seeding. In conclusion, the second functionalization strategy proved to be appropriate for this specific biomaterial and was effective at enhancing the material's bioactivity." @default.
- W4367623897 created "2023-05-02" @default.
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- W4367623897 date "2023-04-29" @default.
- W4367623897 modified "2023-10-18" @default.
- W4367623897 title "Proteolytically Resistant Bioactive Peptide-Grafted Sr/Mg-Doped Hardystonite Foams: Comparison of Two Covalent Functionalization Strategies" @default.
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- W4367623897 cites W1583461005 @default.
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- W4367623897 cites W1893810620 @default.
- W4367623897 cites W1964669234 @default.
- W4367623897 cites W1968650752 @default.
- W4367623897 cites W1971461490 @default.
- W4367623897 cites W1974541015 @default.
- W4367623897 cites W1977778138 @default.
- W4367623897 cites W1979244926 @default.
- W4367623897 cites W1982414211 @default.
- W4367623897 cites W1983090947 @default.
- W4367623897 cites W1984914967 @default.
- W4367623897 cites W1993331221 @default.
- W4367623897 cites W1994427044 @default.
- W4367623897 cites W2005124394 @default.
- W4367623897 cites W2005885719 @default.
- W4367623897 cites W2009355445 @default.
- W4367623897 cites W2014932842 @default.
- W4367623897 cites W2017170100 @default.
- W4367623897 cites W2017470506 @default.
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- W4367623897 cites W2022451964 @default.
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- W4367623897 cites W2030893372 @default.
- W4367623897 cites W2031876019 @default.
- W4367623897 cites W2031894367 @default.
- W4367623897 cites W2032317416 @default.
- W4367623897 cites W2034287320 @default.
- W4367623897 cites W2038090991 @default.
- W4367623897 cites W2051533595 @default.
- W4367623897 cites W2051723453 @default.
- W4367623897 cites W2053105182 @default.
- W4367623897 cites W2054075535 @default.
- W4367623897 cites W2054479973 @default.
- W4367623897 cites W2058963609 @default.
- W4367623897 cites W2071953257 @default.
- W4367623897 cites W2076845879 @default.
- W4367623897 cites W2076909335 @default.
- W4367623897 cites W2086732438 @default.
- W4367623897 cites W2089649420 @default.
- W4367623897 cites W2094003039 @default.
- W4367623897 cites W2104026218 @default.
- W4367623897 cites W2114286636 @default.
- W4367623897 cites W2120184429 @default.
- W4367623897 cites W2125303614 @default.
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- W4367623897 cites W2143808399 @default.
- W4367623897 cites W2145230580 @default.
- W4367623897 cites W2152205487 @default.
- W4367623897 cites W2161091595 @default.
- W4367623897 cites W2163660121 @default.
- W4367623897 cites W2172526540 @default.
- W4367623897 cites W2216079337 @default.
- W4367623897 cites W2304915751 @default.
- W4367623897 cites W2317513811 @default.
- W4367623897 cites W2327945660 @default.
- W4367623897 cites W2345645260 @default.
- W4367623897 cites W2492958053 @default.
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- W4367623897 doi "https://doi.org/10.3390/biomimetics8020185" @default.
- W4367623897 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37218771" @default.
- W4367623897 hasPublicationYear "2023" @default.
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