FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4367624105> ?p ?o ?g. }

• W4367624105 abstract "Abstract Purpose Skin cutaneous melanoma (SKCM) is a malignant tumor responsible for over 75% of skin cancer deaths, the relationship between fibrosis and cancer has been increasingly appreciated. The aim of this study is to investigate the fibrotic gene signature (FGS) in melanoma and construct a prognostic model based on FGS. Methods SKCM-related datasets were obtained from the Gene Expression Omnibus (GEO) database and The Cancer Genome Atlas (TCGA) database. By weighted gene co-expression network analysis (WGCNA) of the TCGA-SKCM cohort and GSE65904 cohort, core modules and central genes highly associated with fibrotic features were identified and intersecting genes were defined as fibrotic gene signature (FGS). The least absolute shrinkage and selection operator (LASSO) regression analysis and the Akaike information criterion (AIC) method were conducted to construct a prognostic model based on the FGS gene set. The fibrotic gene signature enrichment score (FGES) and fibrotic gene signature risk score (FGRS) were used to analyze immune infiltration. For FGRS, the correlation between clinical characteristics and the expression of immune checkpoint genes between different risk groups was also analyzed in depth. Results A total of 301 genes were defined as FGS, and a robust eight-gene prediction model was constructed based on FGS, these 8 genes are SV2A, HEYL, OLFML2A, PROX1, ACOX2, PRRX1, PHACTR1 and LHX6. On the basis of the model, a nomogram consisting of FGRS could accurately predict prognosis. In addition, patients in the high-risk group showed immunosuppression, while patients in the low-risk group may benefit more from immunotherapy. However, there was no significant difference between the immune infiltration of different FGES groups. Conclusion In this study, taken together, we developed a fibrotic gene signature in melanoma, and construct an eight-gene prognostic model based on the FGS to provide a reference for prognosis estimation and treatment selection for melanoma patients." @default.
• W4367624105 created "2023-05-02" @default.
• W4367624105 creator A5004635944 @default.
• W4367624105 creator A5034995105 @default.
• W4367624105 creator A5038403879 @default.
• W4367624105 creator A5085123199 @default.
• W4367624105 date "2023-05-01" @default.
• W4367624105 modified "2023-10-07" @default.
• W4367624105 title "Development of fibrotic gene signature and construction of a prognostic model in melanoma" @default.
• W4367624105 cites W1966327575 @default.
• W4367624105 cites W2032166347 @default.
• W4367624105 cites W2055624262 @default.
• W4367624105 cites W2062809449 @default.
• W4367624105 cites W2117692326 @default.
• W4367624105 cites W2130430382 @default.
• W4367624105 cites W2160431037 @default.
• W4367624105 cites W2533508881 @default.
• W4367624105 cites W2559382297 @default.
• W4367624105 cites W2569821107 @default.
• W4367624105 cites W2753207285 @default.
• W4367624105 cites W2753295600 @default.
• W4367624105 cites W2766466820 @default.
• W4367624105 cites W2786031287 @default.
• W4367624105 cites W2802896169 @default.
• W4367624105 cites W2911526204 @default.
• W4367624105 cites W2913356394 @default.
• W4367624105 cites W2920686366 @default.
• W4367624105 cites W2952065098 @default.
• W4367624105 cites W3004373164 @default.
• W4367624105 cites W3011427624 @default.
• W4367624105 cites W3015664769 @default.
• W4367624105 cites W3016736315 @default.
• W4367624105 cites W3029490475 @default.
• W4367624105 cites W3031693607 @default.
• W4367624105 cites W3031902799 @default.
• W4367624105 cites W3033485776 @default.
• W4367624105 cites W3108480454 @default.
• W4367624105 cites W3109793392 @default.
• W4367624105 cites W3119005666 @default.
• W4367624105 cites W3127581989 @default.
• W4367624105 cites W3162215872 @default.
• W4367624105 cites W3185587603 @default.
• W4367624105 cites W3197265554 @default.
• W4367624105 cites W4224040545 @default.
• W4367624105 doi "https://doi.org/10.1007/s44178-023-00035-y" @default.
• W4367624105 hasPublicationYear "2023" @default.
• W4367624105 type Work @default.
• W4367624105 citedByCount "0" @default.
• W4367624105 crossrefType "journal-article" @default.
• W4367624105 hasAuthorship W4367624105A5004635944 @default.
• W4367624105 hasAuthorship W4367624105A5034995105 @default.
• W4367624105 hasAuthorship W4367624105A5038403879 @default.
• W4367624105 hasAuthorship W4367624105A5085123199 @default.
• W4367624105 hasBestOaLocation W43676241051 @default.
• W4367624105 hasConcept C104317684 @default.
• W4367624105 hasConcept C126322002 @default.
• W4367624105 hasConcept C136764020 @default.
• W4367624105 hasConcept C143998085 @default.
• W4367624105 hasConcept C150194340 @default.
• W4367624105 hasConcept C18431079 @default.
• W4367624105 hasConcept C2777658100 @default.
• W4367624105 hasConcept C2779733811 @default.
• W4367624105 hasConcept C34626388 @default.
• W4367624105 hasConcept C37616216 @default.
• W4367624105 hasConcept C41008148 @default.
• W4367624105 hasConcept C502942594 @default.
• W4367624105 hasConcept C54355233 @default.
• W4367624105 hasConcept C67339327 @default.
• W4367624105 hasConcept C70721500 @default.
• W4367624105 hasConcept C71924100 @default.
• W4367624105 hasConcept C72563966 @default.
• W4367624105 hasConcept C86803240 @default.
• W4367624105 hasConceptScore W4367624105C104317684 @default.
• W4367624105 hasConceptScore W4367624105C126322002 @default.
• W4367624105 hasConceptScore W4367624105C136764020 @default.
• W4367624105 hasConceptScore W4367624105C143998085 @default.
• W4367624105 hasConceptScore W4367624105C150194340 @default.
• W4367624105 hasConceptScore W4367624105C18431079 @default.
• W4367624105 hasConceptScore W4367624105C2777658100 @default.
• W4367624105 hasConceptScore W4367624105C2779733811 @default.
• W4367624105 hasConceptScore W4367624105C34626388 @default.
• W4367624105 hasConceptScore W4367624105C37616216 @default.
• W4367624105 hasConceptScore W4367624105C41008148 @default.
• W4367624105 hasConceptScore W4367624105C502942594 @default.
• W4367624105 hasConceptScore W4367624105C54355233 @default.
• W4367624105 hasConceptScore W4367624105C67339327 @default.
• W4367624105 hasConceptScore W4367624105C70721500 @default.
• W4367624105 hasConceptScore W4367624105C71924100 @default.
• W4367624105 hasConceptScore W4367624105C72563966 @default.
• W4367624105 hasConceptScore W4367624105C86803240 @default.
• W4367624105 hasFunder F4320321001 @default.
• W4367624105 hasIssue "1" @default.
• W4367624105 hasLocation W43676241051 @default.
• W4367624105 hasOpenAccess W4367624105 @default.
• W4367624105 hasPrimaryLocation W43676241051 @default.
• W4367624105 hasRelatedWork W1971166208 @default.
• W4367624105 hasRelatedWork W2111172999 @default.
• W4367624105 hasRelatedWork W2179689986 @default.
• W4367624105 hasRelatedWork W2991486624 @default.
• W4367624105 hasRelatedWork W3154085979 @default.

• next