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- W4367626034 endingPage "623" @default.
- W4367626034 startingPage "623" @default.
- W4367626034 abstract "Alkaloids are the most diversified nitrogen-containing secondary metabolites, having antioxidant and antimicrobial properties, and are extensively used in pharmaceuticals to treat different types of cancer. Nicotiana serves as a reservoir of anti-cancer alkaloids and is also used as a model plant for the de novo synthesis of various anti-cancer molecules through genetic engineering. Up to 4% of the total dry weight of Nicotiana was found to be composed of alkaloids, where nicotine, nornicotine, anatabine, and anabasine are reported as the dominant alkaloids. Additionally, among the alkaloids present in Nicotiana, β-carboline (Harmane and Norharmane) and Kynurenines are found to show anti-tumor effects, especially in the cases of colon and breast cancers. Creating new or shunting of existing biosynthesis pathways in different species of Nicotiana resulted in de novo or increased synthesis of different anti-tumor molecules or their derivatives or precursors including Taxadiane (~22.5 µg/g), Artemisinin (~120 μg/g), Parthenolide (~2.05 ng/g), Costunolide (~60 ng/g), Etoposide (~1 mg/g), Crocin (~400 µg/g), Catharanthine (~60 ng/g), Tabersonine (~10 ng/g), Strictosidine (~0.23 mg/g), etc. Enriching the precursor pool, especially Dimethylallyl Diphosphate (DMAPP), down-regulating other bi-product pathways, compartmentalization or metabolic shunting, or organelle-specific reconstitution of the precursor pool, might trigger the enhanced accumulation of the targeted anti-cancer alkaloid in Nicotiana." @default.
- W4367626034 created "2023-05-02" @default.
- W4367626034 creator A5035560796 @default.
- W4367626034 creator A5046877168 @default.
- W4367626034 creator A5057758263 @default.
- W4367626034 creator A5070743013 @default.
- W4367626034 creator A5083948739 @default.
- W4367626034 date "2023-04-30" @default.
- W4367626034 modified "2023-09-28" @default.
- W4367626034 title "Current Status and De Novo Synthesis of Anti-Tumor Alkaloids in Nicotiana" @default.
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