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- W4367626309 endingPage "8096" @default.
- W4367626309 startingPage "8096" @default.
- W4367626309 abstract "Phafins are PH (Pleckstrin Homology) and FYVE (Fab1, YOTB, Vac1, and EEA1) domain-containing proteins. The Phafin protein family is classified into two groups based on their sequence homology and functional similarity: Phafin1 and Phafin2. This protein family is unique because both the PH and FYVE domains bind to phosphatidylinositol 3-phosphate [PtdIns(3)P], a phosphoinositide primarily found in endosomal and lysosomal membranes. Phafin proteins act as PtdIns(3)P effectors in apoptosis, endocytic cargo trafficking, and autophagy. Additionally, Phafin2 is recruited to macropinocytic compartments through coincidence detection of PtdIns(3)P and PtdIns(4)P. Membrane-associated Phafins serve as adaptor proteins that recruit other binding partners. In addition to the phosphoinositide-binding domains, Phafin proteins present a poly aspartic acid motif that regulates membrane binding specificity. In this review, we summarize the involvement of Phafins in several cellular pathways and their potential physiological functions while highlighting the similarities and differences between Phafin1 and Phafin2. Besides, we discuss research perspectives for Phafins." @default.
- W4367626309 created "2023-05-02" @default.
- W4367626309 creator A5022659484 @default.
- W4367626309 creator A5032763946 @default.
- W4367626309 creator A5041077751 @default.
- W4367626309 date "2023-04-30" @default.
- W4367626309 modified "2023-10-14" @default.
- W4367626309 title "Phafins Are More Than Phosphoinositide-Binding Proteins" @default.
- W4367626309 cites W1499176799 @default.
- W4367626309 cites W1523693806 @default.
- W4367626309 cites W1614056212 @default.
- W4367626309 cites W1745634660 @default.
- W4367626309 cites W1853899559 @default.
- W4367626309 cites W1857386042 @default.
- W4367626309 cites W1885102277 @default.
- W4367626309 cites W1964881184 @default.
- W4367626309 cites W1971078428 @default.
- W4367626309 cites W1974067508 @default.
- W4367626309 cites W1977951612 @default.
- W4367626309 cites W1980827966 @default.
- W4367626309 cites W1981880379 @default.
- W4367626309 cites W1982813242 @default.
- W4367626309 cites W1987769185 @default.
- W4367626309 cites W1988803183 @default.
- W4367626309 cites W1988846133 @default.
- W4367626309 cites W1989165480 @default.
- W4367626309 cites W1994823455 @default.
- W4367626309 cites W1995846848 @default.
- W4367626309 cites W1996527323 @default.
- W4367626309 cites W1997784032 @default.
- W4367626309 cites W1998083136 @default.
- W4367626309 cites W1998284209 @default.
- W4367626309 cites W2002054992 @default.
- W4367626309 cites W2002117007 @default.
- W4367626309 cites W2003787585 @default.
- W4367626309 cites W2004027586 @default.
- W4367626309 cites W2006840724 @default.
- W4367626309 cites W2007970732 @default.
- W4367626309 cites W2010995825 @default.
- W4367626309 cites W2011485864 @default.
- W4367626309 cites W2016040396 @default.
- W4367626309 cites W2016441216 @default.
- W4367626309 cites W2016926114 @default.
- W4367626309 cites W2020025223 @default.
- W4367626309 cites W2020035663 @default.
- W4367626309 cites W2021303199 @default.
- W4367626309 cites W2021490026 @default.
- W4367626309 cites W2025665129 @default.
- W4367626309 cites W2028536701 @default.
- W4367626309 cites W2028641936 @default.
- W4367626309 cites W2031615571 @default.
- W4367626309 cites W2032786799 @default.
- W4367626309 cites W2037065959 @default.
- W4367626309 cites W2043312574 @default.
- W4367626309 cites W2043597075 @default.
- W4367626309 cites W2044406786 @default.
- W4367626309 cites W2044409787 @default.
- W4367626309 cites W2047513332 @default.
- W4367626309 cites W2048030072 @default.
- W4367626309 cites W2050867758 @default.
- W4367626309 cites W2051245442 @default.
- W4367626309 cites W2053644475 @default.
- W4367626309 cites W2054418156 @default.
- W4367626309 cites W2054538338 @default.
- W4367626309 cites W2055523288 @default.
- W4367626309 cites W2063693187 @default.
- W4367626309 cites W2067216245 @default.
- W4367626309 cites W2068715852 @default.
- W4367626309 cites W2071556670 @default.
- W4367626309 cites W2079046612 @default.
- W4367626309 cites W2082379606 @default.
- W4367626309 cites W2087591542 @default.
- W4367626309 cites W2089230333 @default.
- W4367626309 cites W2091161919 @default.
- W4367626309 cites W2091884933 @default.
- W4367626309 cites W2094807146 @default.
- W4367626309 cites W2095016052 @default.
- W4367626309 cites W2096170764 @default.
- W4367626309 cites W2101365401 @default.
- W4367626309 cites W2102916443 @default.
- W4367626309 cites W2103715680 @default.
- W4367626309 cites W2109034822 @default.
- W4367626309 cites W2109716633 @default.
- W4367626309 cites W2113221012 @default.
- W4367626309 cites W2117649547 @default.
- W4367626309 cites W2119746112 @default.
- W4367626309 cites W2120138780 @default.
- W4367626309 cites W2126404692 @default.
- W4367626309 cites W2128537698 @default.
- W4367626309 cites W2135290527 @default.
- W4367626309 cites W2137033600 @default.
- W4367626309 cites W2139552173 @default.
- W4367626309 cites W2147532748 @default.
- W4367626309 cites W2148866212 @default.
- W4367626309 cites W2150597600 @default.
- W4367626309 cites W2154206349 @default.
- W4367626309 cites W2157045574 @default.
- W4367626309 cites W2157963288 @default.