FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4367668483> ?p ?o ?g. }

• W4367668483 endingPage "22804" @default.
• W4367668483 startingPage "22781" @default.
• W4367668483 abstract "A novel class of zinc(II)-based metal complexes, i.e., [Zn2(acdp)(μ-Cl)]·2H2O (1), [Zn2(acdp)(μ-NO3)]·2H2O (2), and [Zn2(acdp)(μ-O2CCF3)]·2H2O (3) (Cl– = chloride; NO3– = nitrate; CF3CO2– = trifluoroacetate) of anthracene-affixed multifunctional organic assembly, H3acdp (H3acdp = N,N′-bis[anthracene-2-ylmethyl]-N,N′-bis[carboxymethyl]-1,3-diaminopropan-2-ol), have emerged as promising antibacterial and antibiofilm agents in the domain of medicinal chemistry. Accordingly, complexes 1–3 were synthesized by utilizing H3acdp in combination with ZnCl2, Zn(NO3)2·6H2O, and Zn(CF3CO2)2·H2O respectively, in the presence of NaOH at ambient temperature. The complexation between H3acdp and Zn2+ was delineated by a combined approach of spectrophotometric and spectrofluorometric titration studies. The stoichiometry of acdp3–/Zn2+ in all three complexes is observed to be 1:2, as confirmed by spectrophotometric/spectrofluorometric titration data. Elemental analysis (C, H, N, Zn), molar conductance, FTIR, UV–vis, and thermoanalytical (TGA/DTA) data were effectively used to characterize these complexes. Besides, the structures of 1–3 were established by density functional theory (DFT) calculation using B3LYP/6-311G, specifying a self-assembled compact geometry with average Zn···Zn separation of 3.4629 Å. All three zinc complexes exhibited significantly high antibacterial and antibiofilm activity against methicillin-resistant Staphylococcus aureus (MRSA BAA1717). However, complex 1 showed a more recognizable activity than 2 and 3, with minimum inhibitory concentration (MIC) values of 200, 350, and 450 μg/mL, respectively. The antimicrobial activity was tested by employing the minimum inhibitory concentration (MIC) and time-kill assay. The crystal violet (CV) assay and microscopic study were performed to examine the antibiofilm activity. As observed, complexes 1–3 had an effect on the production of extracellular polymeric substance (EPS), biofilm cell-viability, and other virulence factors such as staphyloxanthin and hemolysin production, autoaggregation ability, and microbial cell-surface hydrophobicity. Reactive oxygen species (ROS) generated due to inhibition of staphyloxanthin production in response to 1–3 were also analyzed. Moreover, complexes 1–3 showed an ability to damage the bacterial cell membrane due to accumulation of ROS resulting in DNA leakage. In addition, complexes 1–3 displayed a synergistic/additive activity with a commercially available antibiotic drug, vancomycin, with enhanced antibacterial activity. On the whole, our investigation disclosed that complex 1 could be a promising drug lead and attract much attention to medicinal chemists compared to 2 and 3 from therapeutic aspects." @default.
• W4367668483 created "2023-05-03" @default.
• W4367668483 creator A5024049615 @default.
• W4367668483 creator A5028426081 @default.
• W4367668483 creator A5029137171 @default.
• W4367668483 creator A5041842370 @default.
• W4367668483 creator A5054296042 @default.
• W4367668483 creator A5062037958 @default.
• W4367668483 creator A5089295216 @default.
• W4367668483 date "2023-05-02" @default.
• W4367668483 modified "2023-09-29" @default.
• W4367668483 title "Design, Synthesis and Evaluation of a Series of Zinc(II) Complexes of Anthracene-Affixed Multifunctional Organic Assembly as Potential Antibacterial and Antibiofilm Agents against Methicillin-Resistant <i>Staphylococcus aureus</i>" @default.
• W4367668483 cites W1804441130 @default.
• W4367668483 cites W1977420003 @default.
• W4367668483 cites W1977711966 @default.
• W4367668483 cites W1979312713 @default.
• W4367668483 cites W1982929182 @default.
• W4367668483 cites W1987444143 @default.
• W4367668483 cites W1992661805 @default.
• W4367668483 cites W2005353981 @default.
• W4367668483 cites W2008404677 @default.
• W4367668483 cites W2024153870 @default.
• W4367668483 cites W2034964385 @default.
• W4367668483 cites W2035880078 @default.
• W4367668483 cites W2036297514 @default.
• W4367668483 cites W2038685738 @default.
• W4367668483 cites W2041114202 @default.
• W4367668483 cites W2041216606 @default.
• W4367668483 cites W2041350348 @default.
• W4367668483 cites W2041854369 @default.
• W4367668483 cites W2046412723 @default.
• W4367668483 cites W2048924183 @default.
• W4367668483 cites W2054391399 @default.
• W4367668483 cites W2055463190 @default.
• W4367668483 cites W2066987366 @default.
• W4367668483 cites W2105249240 @default.
• W4367668483 cites W2111758967 @default.
• W4367668483 cites W2143981217 @default.
• W4367668483 cites W2161288621 @default.
• W4367668483 cites W2168138948 @default.
• W4367668483 cites W2219255838 @default.
• W4367668483 cites W2237550059 @default.
• W4367668483 cites W2317188986 @default.
• W4367668483 cites W2332226289 @default.
• W4367668483 cites W2364831525 @default.
• W4367668483 cites W2467603663 @default.
• W4367668483 cites W2489693378 @default.
• W4367668483 cites W2505135585 @default.
• W4367668483 cites W2756485531 @default.
• W4367668483 cites W2763274566 @default.
• W4367668483 cites W2793175692 @default.
• W4367668483 cites W2797391676 @default.
• W4367668483 cites W2888479710 @default.
• W4367668483 cites W2897209405 @default.
• W4367668483 cites W2904623744 @default.
• W4367668483 cites W2924812918 @default.
• W4367668483 cites W2964192374 @default.
• W4367668483 cites W2964832583 @default.
• W4367668483 cites W2969434391 @default.
• W4367668483 cites W2975300982 @default.
• W4367668483 cites W2981497166 @default.
• W4367668483 cites W2990266076 @default.
• W4367668483 cites W3011561569 @default.
• W4367668483 cites W3015348761 @default.
• W4367668483 cites W3025713889 @default.
• W4367668483 cites W3033385419 @default.
• W4367668483 cites W3112530758 @default.
• W4367668483 cites W3121782646 @default.
• W4367668483 cites W3136556559 @default.
• W4367668483 cites W3147955499 @default.
• W4367668483 cites W3155049816 @default.
• W4367668483 cites W3168496999 @default.
• W4367668483 cites W3175349600 @default.
• W4367668483 cites W3211567561 @default.
• W4367668483 cites W3215497179 @default.
• W4367668483 cites W4206764679 @default.
• W4367668483 cites W4210471238 @default.
• W4367668483 cites W4210679166 @default.
• W4367668483 cites W4211081122 @default.
• W4367668483 cites W4291910559 @default.
• W4367668483 doi "https://doi.org/10.1021/acsami.2c21899" @default.
• W4367668483 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37129921" @default.
• W4367668483 hasPublicationYear "2023" @default.
• W4367668483 type Work @default.
• W4367668483 citedByCount "3" @default.
• W4367668483 countsByYear W43676684832023 @default.
• W4367668483 crossrefType "journal-article" @default.
• W4367668483 hasAuthorship W4367668483A5024049615 @default.
• W4367668483 hasAuthorship W4367668483A5028426081 @default.
• W4367668483 hasAuthorship W4367668483A5029137171 @default.
• W4367668483 hasAuthorship W4367668483A5041842370 @default.
• W4367668483 hasAuthorship W4367668483A5054296042 @default.
• W4367668483 hasAuthorship W4367668483A5062037958 @default.
• W4367668483 hasAuthorship W4367668483A5089295216 @default.
• W4367668483 hasConcept C13965031 @default.
• W4367668483 hasConcept C144082473 @default.
• W4367668483 hasConcept C176947019 @default.
• W4367668483 hasConcept C178790620 @default.

• next