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- W4367668854 abstract "Ropeginterferon α-2b is a mono-PEGylated proline-interferon for the treatment of polycythemia vera. This drug is used biweekly with a starting dose of 100 μg (50 μg if patients receiving hydroxyurea) and 50 μg increments up to a maximum dose of 500 μg. Increasing evidence indicates that patients can tolerate higher starting doses of ropeginterferon α-2b. This phase II trial utilizes 250 μg as the starting dose, 350 μg at week 2 and 500 μg at week 4 as the target dose. Doses can be adjusted according to tolerability. This study assesses the safety, efficacy and molecular response of ropeginterferon α-2b in Chinese patients with PV utilizing the 250–350–500 μg dosing schema. This study will be used to support the application of a biologics license for polycythemia vera treatment in China." @default.
- W4367668854 created "2023-05-03" @default.
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- W4367668854 date "2023-04-01" @default.
- W4367668854 modified "2023-09-26" @default.
- W4367668854 title "A phase II trial to assess the efficacy and safety of ropeginterferon α-2b in Chinese patients with polycythemia vera" @default.
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- W4367668854 doi "https://doi.org/10.2217/fon-2022-1141" @default.
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