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• W4367668868 abstract "Abstract Building evolutionarily appropriate baseline models for natural populations is not only important for answering fundamental questions in population genetics—including quantifying the relative contributions of adaptive versus nonadaptive processes—but also essential for identifying candidate loci experiencing relatively rare and episodic forms of selection (e.g., positive or balancing selection). Here, a baseline model was developed for a human population of West African ancestry, the Yoruba, comprising processes constantly operating on the genome (i.e., purifying and background selection, population size changes, recombination rate heterogeneity, and gene conversion). Specifically, to perform joint inference of selective effects with demography, an approximate Bayesian approach was employed that utilizes the decay of background selection effects around functional elements, taking into account genomic architecture. This approach inferred a recent 6-fold population growth together with a distribution of fitness effects that is skewed towards effectively neutral mutations. Importantly, these results further suggest that, although strong and/or frequent recurrent positive selection is inconsistent with observed data, weak to moderate positive selection is consistent but unidentifiable if rare." @default.
• W4367668868 created "2023-05-03" @default.
• W4367668868 creator A5020301143 @default.
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• W4367668868 date "2023-05-01" @default.
• W4367668868 modified "2023-10-09" @default.
• W4367668868 title "Developing an Evolutionary Baseline Model for Humans: Jointly Inferring Purifying Selection with Population History" @default.
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• W4367668868 doi "https://doi.org/10.1093/molbev/msad100" @default.
• W4367668868 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37128989" @default.
• W4367668868 hasPublicationYear "2023" @default.
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