FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4367669138> ?p ?o ?g. }

• W4367669138 abstract "Sugammadex (SUG) is a synthetically modified γ-cyclodextrin derivative used in hospitals after surgeries to reverse the neuromuscular blockade induced by rocuronium or vecuronium. In this study, we aimed to develop the first electroanalytical quantification method for sugammadex by using molecular imprinting (MIP) via the electropolymerization (EP) technique. An EP-MIP film was formed by EP on a screen-printed gold electrode (SPAuE) and a new electrochemical sensor, EP-MIP(SUG)/SPAuE, was fabricated using the 4-aminophenol monomer with copper ions to enhance the MIP-binding site. Surface and electrochemical characterization of the EP-MIP(SUG)/SPAuE sensor have been done via scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDX), cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). After screening and optimization studies were carried out to fabricate a MIP-based electrochemical sensor, the analytical performance of EP-MIP(SUG)/SPAuE and the validation parameters were tested according to the ICH guidelines. The specificity/selectivity of the developed sensor has been shown by using common interferents found in the biological fluids and also molecules having similar structures, such as α-cyclodextrin, β-cyclodextrin, and γ-cyclodextrin. As a result, a quantitative analysis method has been developed and validated by using the EP-MIP(SUG)/SPAuE sensor in the concentration range of 0.1-1.0 pM with very high sensitivity (limit of detection: 27.3 fM). The applicability of the method has been shown for bulk drug substances, pharmaceutical dosage forms, and commercial serum samples with good recovery and RSD% results. The EP-MIP(SUG)/SPAuE is the first electrochemical sensor developed for the determination of sugammadex serving the aims of simplicity, short analysis time, and low cost, and has the potential to be adapted in the future as a portable and/or wearable sensor via miniaturization." @default.
• W4367669138 created "2023-05-03" @default.
• W4367669138 creator A5017140738 @default.
• W4367669138 creator A5021297485 @default.
• W4367669138 creator A5042965425 @default.
• W4367669138 creator A5064784474 @default.
• W4367669138 date "2023-01-01" @default.
• W4367669138 modified "2023-10-17" @default.
• W4367669138 title "The electrochemical quantitation method for sugammadex <i>via</i> a molecularly imprinted polymer-based sensor" @default.
• W4367669138 cites W1037114197 @default.
• W4367669138 cites W1982481750 @default.
• W4367669138 cites W1984325709 @default.
• W4367669138 cites W2040417410 @default.
• W4367669138 cites W2058473942 @default.
• W4367669138 cites W2289629300 @default.
• W4367669138 cites W2584642271 @default.
• W4367669138 cites W2965600432 @default.
• W4367669138 cites W2990064844 @default.
• W4367669138 cites W3169027292 @default.
• W4367669138 cites W3171910061 @default.
• W4367669138 cites W3197326301 @default.
• W4367669138 cites W3206047704 @default.
• W4367669138 cites W3206223518 @default.
• W4367669138 cites W3217149862 @default.
• W4367669138 cites W4210294084 @default.
• W4367669138 cites W4214639864 @default.
• W4367669138 cites W4220981892 @default.
• W4367669138 cites W4246593929 @default.
• W4367669138 cites W4254544682 @default.
• W4367669138 cites W4281721637 @default.
• W4367669138 cites W4282832835 @default.
• W4367669138 cites W4296803764 @default.
• W4367669138 cites W4376849549 @default.
• W4367669138 doi "https://doi.org/10.1039/d3ay00452j" @default.
• W4367669138 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37129572" @default.
• W4367669138 hasPublicationYear "2023" @default.
• W4367669138 type Work @default.
• W4367669138 citedByCount "2" @default.
• W4367669138 countsByYear W43676691382023 @default.
• W4367669138 crossrefType "journal-article" @default.
• W4367669138 hasAuthorship W4367669138A5017140738 @default.
• W4367669138 hasAuthorship W4367669138A5021297485 @default.
• W4367669138 hasAuthorship W4367669138A5042965425 @default.
• W4367669138 hasAuthorship W4367669138A5064784474 @default.
• W4367669138 hasConcept C118792377 @default.
• W4367669138 hasConcept C119128265 @default.
• W4367669138 hasConcept C13965031 @default.
• W4367669138 hasConcept C147789679 @default.
• W4367669138 hasConcept C161790260 @default.
• W4367669138 hasConcept C162602672 @default.
• W4367669138 hasConcept C17525397 @default.
• W4367669138 hasConcept C178790620 @default.
• W4367669138 hasConcept C185592680 @default.
• W4367669138 hasConcept C188095982 @default.
• W4367669138 hasConcept C192562407 @default.
• W4367669138 hasConcept C2776277131 @default.
• W4367669138 hasConcept C2776988050 @default.
• W4367669138 hasConcept C2777869211 @default.
• W4367669138 hasConcept C2778560516 @default.
• W4367669138 hasConcept C43617362 @default.
• W4367669138 hasConcept C52859227 @default.
• W4367669138 hasConcept C7040849 @default.
• W4367669138 hasConcept C71924100 @default.
• W4367669138 hasConcept C98274493 @default.
• W4367669138 hasConceptScore W4367669138C118792377 @default.
• W4367669138 hasConceptScore W4367669138C119128265 @default.
• W4367669138 hasConceptScore W4367669138C13965031 @default.
• W4367669138 hasConceptScore W4367669138C147789679 @default.
• W4367669138 hasConceptScore W4367669138C161790260 @default.
• W4367669138 hasConceptScore W4367669138C162602672 @default.
• W4367669138 hasConceptScore W4367669138C17525397 @default.
• W4367669138 hasConceptScore W4367669138C178790620 @default.
• W4367669138 hasConceptScore W4367669138C185592680 @default.
• W4367669138 hasConceptScore W4367669138C188095982 @default.
• W4367669138 hasConceptScore W4367669138C192562407 @default.
• W4367669138 hasConceptScore W4367669138C2776277131 @default.
• W4367669138 hasConceptScore W4367669138C2776988050 @default.
• W4367669138 hasConceptScore W4367669138C2777869211 @default.
• W4367669138 hasConceptScore W4367669138C2778560516 @default.
• W4367669138 hasConceptScore W4367669138C43617362 @default.
• W4367669138 hasConceptScore W4367669138C52859227 @default.
• W4367669138 hasConceptScore W4367669138C7040849 @default.
• W4367669138 hasConceptScore W4367669138C71924100 @default.
• W4367669138 hasConceptScore W4367669138C98274493 @default.
• W4367669138 hasFunder F4320322626 @default.
• W4367669138 hasLocation W43676691381 @default.
• W4367669138 hasLocation W43676691382 @default.
• W4367669138 hasOpenAccess W4367669138 @default.
• W4367669138 hasPrimaryLocation W43676691381 @default.
• W4367669138 hasRelatedWork W2045910631 @default.
• W4367669138 hasRelatedWork W2050913432 @default.
• W4367669138 hasRelatedWork W2065234488 @default.
• W4367669138 hasRelatedWork W2106809339 @default.
• W4367669138 hasRelatedWork W2390273047 @default.
• W4367669138 hasRelatedWork W2567710719 @default.
• W4367669138 hasRelatedWork W2921425225 @default.
• W4367669138 hasRelatedWork W3084042310 @default.
• W4367669138 hasRelatedWork W3214395144 @default.
• W4367669138 hasRelatedWork W4367669138 @default.
• W4367669138 isParatext "false" @default.

• next