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- W4367669815 abstract "Focused ultrasound in conjunction with circulating microbubbles is gaining pace as a new method for non-invasive and targeted drug delivery across biological barriers, such as the blood–brain barrier or the blood–tumour barrier. 1 Meng Y Hynynen K Lipsman N Applications of focused ultrasound in the brain: from thermoablation to drug delivery. Nat Rev Neurol. 2021; 17: 7-22 Crossref PubMed Scopus (110) Google Scholar The gold-standard method of confirming the success of ultrasound treatment has thus far been acquiring a contrast-enhanced MRI scan with a gadolinium-based contrast agent. Although contrast-enhanced MRI provides invaluable information about the location and extent of blood–brain barrier opening, it does not provide a quantifiable estimate of drug delivery enhancement. Repeated blood–brain barrier opening with an implantable ultrasound device for delivery of albumin-bound paclitaxel in patients with recurrent glioblastoma: a phase 1 trialLIPU-MB using a skull-implantable ultrasound device transiently opens the blood–brain barrier allowing for safe, repeated penetration of cytotoxic drugs into the brain. This study has prompted a subsequent phase 2 study combining LIPU-MB with albumin-bound paclitaxel plus carboplatin ( NCT04528680 ), which is ongoing. Full-Text PDF" @default.
- W4367669815 created "2023-05-03" @default.
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- W4367669815 date "2023-05-01" @default.
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- W4367669815 title "Evaluating drug delivery enhancement following ultrasound treatment" @default.
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- W4367669815 doi "https://doi.org/10.1016/s1470-2045(23)00149-3" @default.
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