FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4367671448> ?p ?o ?g. }

• W4367671448 endingPage "2299.e10" @default.
• W4367671448 startingPage "2291" @default.
• W4367671448 abstract "During mitosis, chromosomes assemble kinetochores to dynamically couple with spindle microtubules.1,2 Kinetochores also function as signaling hubs directing mitotic progression by recruiting and controlling the fate of the anaphase promoting complex/cyclosome (APC/C) activator CDC-20.3,4,5 Kinetochores either incorporate CDC-20 into checkpoint complexes that inhibit the APC/C or dephosphorylate CDC-20, which allows it to interact with and activate the APC/C.4,6 The importance of these two CDC-20 fates likely depends on the biological context. In human somatic cells, the major mechanism controlling mitotic progression is the spindle checkpoint. By contrast, progression through mitosis during the cell cycles of early embryos is largely checkpoint independent.7,8,9,10 Here, we first show that CDC-20 phosphoregulation controls mitotic duration in the C. elegans embryo and defines a checkpoint-independent temporal mitotic optimum for robust embryogenesis. CDC-20 phosphoregulation occurs at kinetochores and in the cytosol. At kinetochores, the flux of CDC-20 for local dephosphorylation requires an ABBA motif on BUB-1 that directly interfaces with the structured WD40 domain of CDC-20.6,11,12,13 We next show that a conserved STP motif in BUB-1 that docks the mitotic kinase PLK-114 is necessary for CDC-20 kinetochore recruitment and timely mitotic progression. The kinase activity of PLK-1 is required for CDC-20 to localize to kinetochores and phosphorylates the CDC-20-binding ABBA motif of BUB-1 to promote BUB-1-CDC-20 interaction and mitotic progression. Thus, the BUB-1-bound pool of PLK-1 ensures timely mitosis during embryonic cell cycles by promoting CDC-20 recruitment to the vicinity of kinetochore-localized phosphatase activity." @default.
• W4367671448 created "2023-05-03" @default.
• W4367671448 creator A5023841104 @default.
• W4367671448 creator A5026504117 @default.
• W4367671448 creator A5028905178 @default.
• W4367671448 creator A5045000685 @default.
• W4367671448 creator A5060356943 @default.
• W4367671448 creator A5060382413 @default.
• W4367671448 creator A5069446967 @default.
• W4367671448 creator A5076330651 @default.
• W4367671448 creator A5082912880 @default.
• W4367671448 date "2023-06-01" @default.
• W4367671448 modified "2023-10-13" @default.
• W4367671448 title "BUB-1-bound PLK-1 directs CDC-20 kinetochore recruitment to ensure timely embryonic mitoses" @default.
• W4367671448 cites W1505048543 @default.
• W4367671448 cites W1570287916 @default.
• W4367671448 cites W1902946625 @default.
• W4367671448 cites W1965143113 @default.
• W4367671448 cites W1967100183 @default.
• W4367671448 cites W1979983744 @default.
• W4367671448 cites W1992756342 @default.
• W4367671448 cites W2012229898 @default.
• W4367671448 cites W2048635498 @default.
• W4367671448 cites W2067518266 @default.
• W4367671448 cites W2071209248 @default.
• W4367671448 cites W2074578453 @default.
• W4367671448 cites W2088629534 @default.
• W4367671448 cites W2100984467 @default.
• W4367671448 cites W2110109595 @default.
• W4367671448 cites W2112854488 @default.
• W4367671448 cites W2118221662 @default.
• W4367671448 cites W2127283099 @default.
• W4367671448 cites W2131725400 @default.
• W4367671448 cites W2133023225 @default.
• W4367671448 cites W2133435867 @default.
• W4367671448 cites W2151248947 @default.
• W4367671448 cites W2151544800 @default.
• W4367671448 cites W2161659315 @default.
• W4367671448 cites W2163336334 @default.
• W4367671448 cites W2167279371 @default.
• W4367671448 cites W2263863969 @default.
• W4367671448 cites W2295819104 @default.
• W4367671448 cites W2331746516 @default.
• W4367671448 cites W2510568608 @default.
• W4367671448 cites W2582965622 @default.
• W4367671448 cites W2605356232 @default.
• W4367671448 cites W2735061684 @default.
• W4367671448 cites W2766134084 @default.
• W4367671448 cites W2768822987 @default.
• W4367671448 cites W2769618080 @default.
• W4367671448 cites W3038257345 @default.
• W4367671448 cites W3047383774 @default.
• W4367671448 cites W3109486370 @default.
• W4367671448 cites W3110459767 @default.
• W4367671448 cites W3115291379 @default.
• W4367671448 cites W3117985554 @default.
• W4367671448 cites W3118870950 @default.
• W4367671448 cites W3131059783 @default.
• W4367671448 cites W3144569393 @default.
• W4367671448 cites W3176219224 @default.
• W4367671448 cites W3177828909 @default.
• W4367671448 cites W4229736484 @default.
• W4367671448 cites W4281790889 @default.
• W4367671448 cites W4293102909 @default.
• W4367671448 cites W4366083972 @default.
• W4367671448 doi "https://doi.org/10.1016/j.cub.2023.04.021" @default.
• W4367671448 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37137308" @default.
• W4367671448 hasPublicationYear "2023" @default.
• W4367671448 type Work @default.
• W4367671448 citedByCount "4" @default.
• W4367671448 countsByYear W43676714482023 @default.
• W4367671448 crossrefType "journal-article" @default.
• W4367671448 hasAuthorship W4367671448A5023841104 @default.
• W4367671448 hasAuthorship W4367671448A5026504117 @default.
• W4367671448 hasAuthorship W4367671448A5028905178 @default.
• W4367671448 hasAuthorship W4367671448A5045000685 @default.
• W4367671448 hasAuthorship W4367671448A5060356943 @default.
• W4367671448 hasAuthorship W4367671448A5060382413 @default.
• W4367671448 hasAuthorship W4367671448A5069446967 @default.
• W4367671448 hasAuthorship W4367671448A5076330651 @default.
• W4367671448 hasAuthorship W4367671448A5082912880 @default.
• W4367671448 hasConcept C104317684 @default.
• W4367671448 hasConcept C141937037 @default.
• W4367671448 hasConcept C1491633281 @default.
• W4367671448 hasConcept C175732170 @default.
• W4367671448 hasConcept C192838845 @default.
• W4367671448 hasConcept C29537977 @default.
• W4367671448 hasConcept C30481170 @default.
• W4367671448 hasConcept C47432576 @default.
• W4367671448 hasConcept C53420372 @default.
• W4367671448 hasConcept C54355233 @default.
• W4367671448 hasConcept C6391034 @default.
• W4367671448 hasConcept C85813293 @default.
• W4367671448 hasConcept C86803240 @default.
• W4367671448 hasConcept C93304396 @default.
• W4367671448 hasConcept C95444343 @default.
• W4367671448 hasConceptScore W4367671448C104317684 @default.
• W4367671448 hasConceptScore W4367671448C141937037 @default.

• next