Matches in SemOpenAlex for { <https://semopenalex.org/work/W4367671520> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W4367671520 abstract "<div>AbstractPurpose:<p>Homologous recombination deficiency (HRD) is closely related to PARP inhibitor (PARPi) benefit in ovarian cancer. The capacity of <i>BRCA1</i> promoter methylation to predict prognosis and HRD status remains unclear. We aimed to correlate <i>BRCA1</i> promoter methylation levels in patients with high-grade ovarian cancer to HRD status and clinical behavior to assess its clinical relevance.</p>Experimental Design:<p>This is a retrospective monocentric analysis of patients centrally tested for genomic instability score (GIS) by MyChoice CDx (Myriad Genetics). The detection of <i>BRCA1</i> promoter methylation and quantification of methylation levels were performed by quantitative droplet digital PCR methodology. High <i>BRCA1</i> methylation was defined as ≥70% and deemed to be associated with homozygous silencing.</p>Results:<p>Of 100 patients, 11% harbored a deleterious <i>BRCA1/2</i> mutation. GIS was considered positive (score ≥ 42) for 52 patients and negative for 48 patients. Using a 70% cutoff, 19% (15/79) of <i>BRCA</i> wild-type ovarian cancer had high <i>BRCA1</i> methylation levels. All of the highly methylated tumors were classified as HRD, achieving a positive predictive value of 100%. We detected 14% (11/79) low-methylated tumors (1%–69%), and all of them were also classified as HRD. Mean GIS was 61.5 for <i>BRCA</i>mut, 66.4 for high-<i>BRCA</i>meth, 58.9 for low-<i>BRCA</i>meth, and 33.3 for <i>BRCA</i>wt unmethylated (<i>P</i> < 0.001). Low methylation levels detected in samples previously exposed to chemotherapy appeared to be associated with poor outcome post-platinum.</p>Conclusions:<p>Patients with ovarian cancer with high levels of <i>BRCA1</i> hypermethylation are very likely to have high GIS and therefore represent good candidates for PARPi treatment. These results may be highly relevant to other tumor types for HRD prediction.</p></div>" @default.
- W4367671520 created "2023-05-03" @default.
- W4367671520 creator A5001949379 @default.
- W4367671520 creator A5005029412 @default.
- W4367671520 creator A5014141555 @default.
- W4367671520 creator A5020088855 @default.
- W4367671520 creator A5025155327 @default.
- W4367671520 creator A5051107144 @default.
- W4367671520 creator A5053272098 @default.
- W4367671520 creator A5057537978 @default.
- W4367671520 creator A5057547196 @default.
- W4367671520 creator A5070881504 @default.
- W4367671520 creator A5072444326 @default.
- W4367671520 creator A5084210028 @default.
- W4367671520 creator A5085131772 @default.
- W4367671520 creator A5090177578 @default.
- W4367671520 creator A5000130570 @default.
- W4367671520 creator A5048004186 @default.
- W4367671520 creator A5067427854 @default.
- W4367671520 creator A5077499896 @default.
- W4367671520 date "2023-05-02" @default.
- W4367671520 modified "2023-09-26" @default.
- W4367671520 title "Data from Clinical Relevance of <i>BRCA1</i> Promoter Methylation Testing in Patients with Ovarian Cancer" @default.
- W4367671520 doi "https://doi.org/10.1158/1078-0432.c.6626956.v1" @default.
- W4367671520 hasPublicationYear "2023" @default.
- W4367671520 type Work @default.
- W4367671520 citedByCount "0" @default.
- W4367671520 crossrefType "posted-content" @default.
- W4367671520 hasAuthorship W4367671520A5000130570 @default.
- W4367671520 hasAuthorship W4367671520A5001949379 @default.
- W4367671520 hasAuthorship W4367671520A5005029412 @default.
- W4367671520 hasAuthorship W4367671520A5014141555 @default.
- W4367671520 hasAuthorship W4367671520A5020088855 @default.
- W4367671520 hasAuthorship W4367671520A5025155327 @default.
- W4367671520 hasAuthorship W4367671520A5048004186 @default.
- W4367671520 hasAuthorship W4367671520A5051107144 @default.
- W4367671520 hasAuthorship W4367671520A5053272098 @default.
- W4367671520 hasAuthorship W4367671520A5057537978 @default.
- W4367671520 hasAuthorship W4367671520A5057547196 @default.
- W4367671520 hasAuthorship W4367671520A5067427854 @default.
- W4367671520 hasAuthorship W4367671520A5070881504 @default.
- W4367671520 hasAuthorship W4367671520A5072444326 @default.
- W4367671520 hasAuthorship W4367671520A5077499896 @default.
- W4367671520 hasAuthorship W4367671520A5084210028 @default.
- W4367671520 hasAuthorship W4367671520A5085131772 @default.
- W4367671520 hasAuthorship W4367671520A5090177578 @default.
- W4367671520 hasBestOaLocation W43676715202 @default.
- W4367671520 hasConcept C101762097 @default.
- W4367671520 hasConcept C104317684 @default.
- W4367671520 hasConcept C119056186 @default.
- W4367671520 hasConcept C121608353 @default.
- W4367671520 hasConcept C126322002 @default.
- W4367671520 hasConcept C143998085 @default.
- W4367671520 hasConcept C150194340 @default.
- W4367671520 hasConcept C153911025 @default.
- W4367671520 hasConcept C190727270 @default.
- W4367671520 hasConcept C2780427987 @default.
- W4367671520 hasConcept C33288867 @default.
- W4367671520 hasConcept C502942594 @default.
- W4367671520 hasConcept C54355233 @default.
- W4367671520 hasConcept C71924100 @default.
- W4367671520 hasConcept C86803240 @default.
- W4367671520 hasConceptScore W4367671520C101762097 @default.
- W4367671520 hasConceptScore W4367671520C104317684 @default.
- W4367671520 hasConceptScore W4367671520C119056186 @default.
- W4367671520 hasConceptScore W4367671520C121608353 @default.
- W4367671520 hasConceptScore W4367671520C126322002 @default.
- W4367671520 hasConceptScore W4367671520C143998085 @default.
- W4367671520 hasConceptScore W4367671520C150194340 @default.
- W4367671520 hasConceptScore W4367671520C153911025 @default.
- W4367671520 hasConceptScore W4367671520C190727270 @default.
- W4367671520 hasConceptScore W4367671520C2780427987 @default.
- W4367671520 hasConceptScore W4367671520C33288867 @default.
- W4367671520 hasConceptScore W4367671520C502942594 @default.
- W4367671520 hasConceptScore W4367671520C54355233 @default.
- W4367671520 hasConceptScore W4367671520C71924100 @default.
- W4367671520 hasConceptScore W4367671520C86803240 @default.
- W4367671520 hasLocation W43676715201 @default.
- W4367671520 hasLocation W43676715202 @default.
- W4367671520 hasOpenAccess W4367671520 @default.
- W4367671520 hasPrimaryLocation W43676715201 @default.
- W4367671520 hasRelatedWork W1519915707 @default.
- W4367671520 hasRelatedWork W1977466383 @default.
- W4367671520 hasRelatedWork W1999023151 @default.
- W4367671520 hasRelatedWork W2064587649 @default.
- W4367671520 hasRelatedWork W2084654188 @default.
- W4367671520 hasRelatedWork W2103991348 @default.
- W4367671520 hasRelatedWork W2113437172 @default.
- W4367671520 hasRelatedWork W2132891826 @default.
- W4367671520 hasRelatedWork W2144473770 @default.
- W4367671520 hasRelatedWork W2415020212 @default.
- W4367671520 isParatext "false" @default.
- W4367671520 isRetracted "false" @default.
- W4367671520 workType "article" @default.