FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4367671635> ?p ?o ?g. }

• W4367671635 endingPage "141" @default.
• W4367671635 startingPage "133" @default.
• W4367671635 abstract "Background Although a substantial impetus behind disparities research in healthcare exists, those that are sex-related within vascular surgery outcomes are largely unexplored. Consequently, published guidelines lack specificity when it comes to treating male and female patients with vascular disease. Disparities related to patients suffering from chronic limb-threatening ischemia have been broached, although no extensive studies assessing disparities in acute limb ischemia treatment outcomes have come to the forefront. In this study, our aim is to identify and quantify sex-related disparities as they pertain to interventions for acute limb ischemia. Methods Using the TriNetX global research network, we conducted a multicenter query across 48 healthcare organizations spanning 5 countries for patients treated for acute limb ischemia. We determined the number of male and female patients that received one of the following interventions: open revascularization, percutaneous mechanical thrombectomy, or catheter-directed thrombolysis and/or adjunctive endovascular procedures. Propensity score matching was performed to account for comorbidities. Risk of adverse outcomes within 30 days was calculated for each sex, including reintervention, major amputation, and death. Risk of adverse outcomes was then compared between treatment groups of the same sex and between sexes. Type-I errors were reduced through utilization of the Holm-Bonferroni method to correct P values. Results Within our study, we noted several important findings. Females were more likely to receive catheter-directed thrombolysis and/or adjunctive endovascular procedures (P = 0.001) than males. There were no significant differences in the rates of open revascularization or percutaneous mechanical thrombectomy between males and females. Overall, females were more likely to die within 30 days (P < 0.0001) and greater number of males required reintervention within 30 days (P < 0.0001). Analyzing outcomes within individual treatment groups, females undergoing open revascularization or catheter-directed thrombolysis and/or adjunctive endovascular intervention demonstrated a profound increase in mortality within 30 days of intervention (P = 0.0072 and P = 0.0206, respectively), but these differences were not reflected in the percutaneous mechanical thrombectomy group. Limb salvage rates in females were higher than males overall although there were no significant sex differences within any treatment groups specifically. Conclusions In conclusion, there was a significantly higher risk of death in females across all treatment groups in the studied timeframe. Limb salvage rates were higher for females in the open revascularization (OR) treatment group, while males were more likely to require a reintervention across all treatment groups. By evaluating these disparities, we can provide greater insight into personalized treatment for patients presenting with acute limb ischemia. Although a substantial impetus behind disparities research in healthcare exists, those that are sex-related within vascular surgery outcomes are largely unexplored. Consequently, published guidelines lack specificity when it comes to treating male and female patients with vascular disease. Disparities related to patients suffering from chronic limb-threatening ischemia have been broached, although no extensive studies assessing disparities in acute limb ischemia treatment outcomes have come to the forefront. In this study, our aim is to identify and quantify sex-related disparities as they pertain to interventions for acute limb ischemia. Using the TriNetX global research network, we conducted a multicenter query across 48 healthcare organizations spanning 5 countries for patients treated for acute limb ischemia. We determined the number of male and female patients that received one of the following interventions: open revascularization, percutaneous mechanical thrombectomy, or catheter-directed thrombolysis and/or adjunctive endovascular procedures. Propensity score matching was performed to account for comorbidities. Risk of adverse outcomes within 30 days was calculated for each sex, including reintervention, major amputation, and death. Risk of adverse outcomes was then compared between treatment groups of the same sex and between sexes. Type-I errors were reduced through utilization of the Holm-Bonferroni method to correct P values. Within our study, we noted several important findings. Females were more likely to receive catheter-directed thrombolysis and/or adjunctive endovascular procedures (P = 0.001) than males. There were no significant differences in the rates of open revascularization or percutaneous mechanical thrombectomy between males and females. Overall, females were more likely to die within 30 days (P < 0.0001) and greater number of males required reintervention within 30 days (P < 0.0001). Analyzing outcomes within individual treatment groups, females undergoing open revascularization or catheter-directed thrombolysis and/or adjunctive endovascular intervention demonstrated a profound increase in mortality within 30 days of intervention (P = 0.0072 and P = 0.0206, respectively), but these differences were not reflected in the percutaneous mechanical thrombectomy group. Limb salvage rates in females were higher than males overall although there were no significant sex differences within any treatment groups specifically. In conclusion, there was a significantly higher risk of death in females across all treatment groups in the studied timeframe. Limb salvage rates were higher for females in the open revascularization (OR) treatment group, while males were more likely to require a reintervention across all treatment groups. By evaluating these disparities, we can provide greater insight into personalized treatment for patients presenting with acute limb ischemia." @default.
• W4367671635 created "2023-05-03" @default.
• W4367671635 creator A5000655672 @default.
• W4367671635 creator A5007415726 @default.
• W4367671635 creator A5024723071 @default.
• W4367671635 creator A5059834149 @default.
• W4367671635 date "2023-09-01" @default.
• W4367671635 modified "2023-10-14" @default.
• W4367671635 title "Sex-Related Disparities in Acute Limb Ischemia Treatment Outcomes" @default.
• W4367671635 cites W1892655446 @default.
• W4367671635 cites W1976695991 @default.
• W4367671635 cites W1984522888 @default.
• W4367671635 cites W2004389985 @default.
• W4367671635 cites W2064657550 @default.
• W4367671635 cites W2070708034 @default.
• W4367671635 cites W2095219849 @default.
• W4367671635 cites W2139500804 @default.
• W4367671635 cites W2159523026 @default.
• W4367671635 cites W2178193609 @default.
• W4367671635 cites W2521995411 @default.
• W4367671635 cites W2605470762 @default.
• W4367671635 cites W2796295063 @default.
• W4367671635 cites W2804406907 @default.
• W4367671635 cites W3003678354 @default.
• W4367671635 cites W3113359386 @default.
• W4367671635 cites W3122226502 @default.
• W4367671635 cites W4225823260 @default.
• W4367671635 doi "https://doi.org/10.1016/j.avsg.2023.04.004" @default.
• W4367671635 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37142119" @default.
• W4367671635 hasPublicationYear "2023" @default.
• W4367671635 type Work @default.
• W4367671635 citedByCount "0" @default.
• W4367671635 crossrefType "journal-article" @default.
• W4367671635 hasAuthorship W4367671635A5000655672 @default.
• W4367671635 hasAuthorship W4367671635A5007415726 @default.
• W4367671635 hasAuthorship W4367671635A5024723071 @default.
• W4367671635 hasAuthorship W4367671635A5059834149 @default.
• W4367671635 hasConcept C118552586 @default.
• W4367671635 hasConcept C126322002 @default.
• W4367671635 hasConcept C141071460 @default.
• W4367671635 hasConcept C17923572 @default.
• W4367671635 hasConcept C197934379 @default.
• W4367671635 hasConcept C27415008 @default.
• W4367671635 hasConcept C2776204877 @default.
• W4367671635 hasConcept C2779464278 @default.
• W4367671635 hasConcept C2779581417 @default.
• W4367671635 hasConcept C2780813298 @default.
• W4367671635 hasConcept C2781099653 @default.
• W4367671635 hasConcept C2781267111 @default.
• W4367671635 hasConcept C500558357 @default.
• W4367671635 hasConcept C541997718 @default.
• W4367671635 hasConcept C71924100 @default.
• W4367671635 hasConceptScore W4367671635C118552586 @default.
• W4367671635 hasConceptScore W4367671635C126322002 @default.
• W4367671635 hasConceptScore W4367671635C141071460 @default.
• W4367671635 hasConceptScore W4367671635C17923572 @default.
• W4367671635 hasConceptScore W4367671635C197934379 @default.
• W4367671635 hasConceptScore W4367671635C27415008 @default.
• W4367671635 hasConceptScore W4367671635C2776204877 @default.
• W4367671635 hasConceptScore W4367671635C2779464278 @default.
• W4367671635 hasConceptScore W4367671635C2779581417 @default.
• W4367671635 hasConceptScore W4367671635C2780813298 @default.
• W4367671635 hasConceptScore W4367671635C2781099653 @default.
• W4367671635 hasConceptScore W4367671635C2781267111 @default.
• W4367671635 hasConceptScore W4367671635C500558357 @default.
• W4367671635 hasConceptScore W4367671635C541997718 @default.
• W4367671635 hasConceptScore W4367671635C71924100 @default.
• W4367671635 hasLocation W43676716351 @default.
• W4367671635 hasLocation W43676716352 @default.
• W4367671635 hasOpenAccess W4367671635 @default.
• W4367671635 hasPrimaryLocation W43676716351 @default.
• W4367671635 hasRelatedWork W161339683 @default.
• W4367671635 hasRelatedWork W1687998444 @default.
• W4367671635 hasRelatedWork W2054835602 @default.
• W4367671635 hasRelatedWork W2139989692 @default.
• W4367671635 hasRelatedWork W2313480767 @default.
• W4367671635 hasRelatedWork W2357340247 @default.
• W4367671635 hasRelatedWork W2745353666 @default.
• W4367671635 hasRelatedWork W2844153221 @default.
• W4367671635 hasRelatedWork W2887936019 @default.
• W4367671635 hasRelatedWork W3173688903 @default.
• W4367671635 hasVolume "95" @default.
• W4367671635 isParatext "false" @default.
• W4367671635 isRetracted "false" @default.
• W4367671635 workType "article" @default.