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- W4367671805 endingPage "121755" @default.
- W4367671805 startingPage "121755" @default.
- W4367671805 abstract "Adverse male reproduction caused by phthalate ester (PAE) exposure has been well documented in vivo. However, existing evidence from population studies remains inadequate to demonstrate the impact of PAE exposure on spermatogenesis and underlying mechanisms. Our present study aimed to explore the potential link between PAE exposure and sperm quality and the possible mediation by sperm mitochondrial and telomere in healthy male adults recruited from the Hubei Province Human Sperm Bank, China. Nine PAEs were determined in one pooled urine sample prepared from multiple collections during the spermatogenesis period from the same participant. Sperm telomere length (TL) and mitochondrial DNA copy number (mtDNAcn) were determined in sperm samples. The sperm concentration and count per quartile increment in mixture concentrations were −4.10 million/mL (−7.12, −1.08) and −13.52% (−21.62%, −4.59%), respectively. We found one quartile increase in PAE mixture concentrations to be marginally associated with sperm mtDNAcn (β = 0.09, 95% CI: −0.01, 0.19). Mediation analysis showed that sperm mtDNAcn significantly explained 24.6% and 32.5% of the relationships of mono-2-ethylhexyl phthalate (MEHP) with sperm concentration and sperm count (β = −0.44 million/mL, 95% CI: −0.82, −0.08; β = −1.35, 95% CI: −2.54, −0.26, respectively). Our study provided a novel insight into the mixed effect of PAEs on adverse semen quality and the potential mediation role of sperm mtDNAcn." @default.
- W4367671805 created "2023-05-03" @default.
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- W4367671805 date "2023-08-01" @default.
- W4367671805 modified "2023-10-02" @default.
- W4367671805 title "Phthalate exposure with sperm quality among healthy Chinese male adults: The role of sperm cellular function" @default.
- W4367671805 cites W1511492317 @default.
- W4367671805 cites W1719634939 @default.
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- W4367671805 cites W1967553734 @default.
- W4367671805 cites W1978421061 @default.
- W4367671805 cites W1990320858 @default.
- W4367671805 cites W2003185613 @default.
- W4367671805 cites W2021528199 @default.
- W4367671805 cites W2027783468 @default.
- W4367671805 cites W2037511493 @default.
- W4367671805 cites W2039744318 @default.
- W4367671805 cites W2047760682 @default.
- W4367671805 cites W2050711948 @default.
- W4367671805 cites W2054592293 @default.
- W4367671805 cites W2071484008 @default.
- W4367671805 cites W2096282522 @default.
- W4367671805 cites W2108166727 @default.
- W4367671805 cites W2109867862 @default.
- W4367671805 cites W2117843333 @default.
- W4367671805 cites W2121189111 @default.
- W4367671805 cites W2125734753 @default.
- W4367671805 cites W2128128123 @default.
- W4367671805 cites W2136239288 @default.
- W4367671805 cites W2148598270 @default.
- W4367671805 cites W2149654569 @default.
- W4367671805 cites W2157271021 @default.
- W4367671805 cites W2159650080 @default.
- W4367671805 cites W2210328875 @default.
- W4367671805 cites W2218002617 @default.
- W4367671805 cites W2317405494 @default.
- W4367671805 cites W2324161295 @default.
- W4367671805 cites W2324339700 @default.
- W4367671805 cites W2328581228 @default.
- W4367671805 cites W2509302644 @default.
- W4367671805 cites W2534537490 @default.
- W4367671805 cites W2578684539 @default.
- W4367671805 cites W2739521243 @default.
- W4367671805 cites W2751775623 @default.
- W4367671805 cites W2758683626 @default.
- W4367671805 cites W2770158317 @default.
- W4367671805 cites W2790415395 @default.
- W4367671805 cites W2797524993 @default.
- W4367671805 cites W2900643389 @default.
- W4367671805 cites W2906229866 @default.
- W4367671805 cites W2914169111 @default.
- W4367671805 cites W2915016404 @default.
- W4367671805 cites W2918173153 @default.
- W4367671805 cites W2923402875 @default.
- W4367671805 cites W2953412526 @default.
- W4367671805 cites W2976520497 @default.
- W4367671805 cites W2989483426 @default.
- W4367671805 cites W2989594115 @default.
- W4367671805 cites W2991526683 @default.
- W4367671805 cites W2995089715 @default.
- W4367671805 cites W2995933627 @default.
- W4367671805 cites W3005857778 @default.
- W4367671805 cites W3012074820 @default.
- W4367671805 cites W3034209604 @default.
- W4367671805 cites W3035133381 @default.
- W4367671805 cites W3036202933 @default.
- W4367671805 cites W3041344852 @default.
- W4367671805 cites W3042915496 @default.
- W4367671805 cites W3047664191 @default.
- W4367671805 cites W3089002614 @default.
- W4367671805 cites W3113370741 @default.
- W4367671805 cites W3130721084 @default.
- W4367671805 cites W3133896934 @default.
- W4367671805 cites W3204400069 @default.
- W4367671805 cites W3214706510 @default.
- W4367671805 cites W4211248086 @default.
- W4367671805 cites W4220978036 @default.
- W4367671805 cites W4221137526 @default.
- W4367671805 cites W4229029324 @default.
- W4367671805 cites W4292111447 @default.
- W4367671805 cites W4292546430 @default.
- W4367671805 cites W4311118689 @default.
- W4367671805 cites W561411734 @default.
- W4367671805 doi "https://doi.org/10.1016/j.envpol.2023.121755" @default.
- W4367671805 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37142207" @default.
- W4367671805 hasPublicationYear "2023" @default.