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- W4367672274 abstract "• A simple and efficient protocol for the α-halogenation of ring A of withaferin A followed by palladium-mediated coupling of 2-iodowithaferin A with boronic acids leads to the generation of 2-aryl withaferin A analogs. • A series of 18 new 2-aryl analogs of withaferin A have been synthesized and evaluated for their anticancer potential against four cell lines. • One of the newly generated derivative, 2-(4-bromophenyl)-withaferin A (9) showed ≥ 50 % growth inhibition against all the tested cell lines at 10 μM concentration with an IC 50 of 6.6 ± 0.8 against triple-negative breast cancer cell line MDA-MB-231. • Compound 9 implicated suppression of cellular proliferation , colony formation, cell migration and cell invasion in TNBC cells. • Cell cycle analysis showed that compound 9 arrests G1 phase of cell cycle in triple negative breast cancer cells MDA-MB-231." @default.
- W4367672274 created "2023-05-03" @default.
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- W4367672274 date "2023-07-01" @default.
- W4367672274 modified "2023-10-17" @default.
- W4367672274 title "Suzuki coupling-based synthesis and in vitro cytotoxic evaluation of C-2 aryl derivatives of Withaferin A" @default.
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- W4367672274 doi "https://doi.org/10.1016/j.steroids.2023.109246" @default.
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