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• W4367673744 abstract "Abstract Biofilm formation begins when bacteria contacting a surface induce cellular changes to become better adapted for surface growth. One of the first changes to occur for Pseudomonas aeruginosa after surface contact is an increase in the nucleotide second messenger 3’,5’-cyclic adenosine monophosphate (cAMP). It has been demonstrated that this increase in intracellular cAMP is dependent on functional Type IV pili (T4P) relaying a signal to the Pil-Chp system, but the mechanism by which this signal is transduced remains poorly understood. Here, we investigate the role of the Type IV pili retraction motor PilT in sensing a surface and relaying that signal to cAMP production. We show that mutations affecting the structure of PilT and in particular ATPase activity of this motor protein, reduce surface-dependent cAMP production. We identify a novel interaction between PilT and PilJ, a member of the Pil-Chp system, and propose a new model whereby P. aeruginosa uses its retraction motor to sense a surface and to relay that signal via PilJ to increased production of cAMP. We discuss these findings in light of current TFP-dependent surface sensing models for P. aeruginosa . Importance T4P are cellular appendages that allow P. aeruginosa to sense a surface leading to the production of cAMP. This second messenger not only activates virulence pathways but leads to further surface adaptation and irreversible attachment of cells. Here, we demonstrate the importance of the retraction motor PilT in surface sensing. We also present a new surface sensing model in P. aeruginosa whereby the T4P retraction motor PilT senses and transmits the surface signal, likely via its ATPase domain and interaction with PilJ, to mediate production of the second messenger cAMP." @default.
• W4367673744 created "2023-05-03" @default.
• W4367673744 creator A5036077732 @default.
• W4367673744 creator A5037293205 @default.
• W4367673744 date "2023-05-02" @default.
• W4367673744 modified "2023-10-01" @default.
• W4367673744 title "Evidence for the Type IV Pili Retraction Motor PilT as a Component of the Surface Sensing System in<i>Pseudomonas aeruginosa</i>" @default.
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• W4367673744 doi "https://doi.org/10.1101/2023.05.02.539127" @default.
• W4367673744 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37205505" @default.
• W4367673744 hasPublicationYear "2023" @default.
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