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- W4367676831 abstract "Abstract Objective Long noncoding RNAs (lncRNAs) are significant regulators in gastric cancer（GC）; However, studies of their mechanisms of action are needed to determine their clinical value. In this study, we investigated the effects and mechanism of action of THUMPD3-AS1 in GC. Methods Candidate lncRNAs and mRNAs were getted from The Cancer Genome Atlas, revealing the differential expression and prognostic significance of THUMPD3-AS1-BCAT1 in GC. qRT-PCR was performed to detect THUMPD3-AS1 levels in GC samples and cell lines. CCK8, scratch wound healing, and Transwell assays as well as experiments in vivo were conducted to evaluate the function of THUMPD3-AS1 in GC. Related genes were analysed to detect interactions between THUMPD3-AS1, BCAT1, and miR-1297. Results THUMPD3-AS1 levels were significantly elevated in GC and were positively correlated with poor prognosis. Functionally, THUMPD3-AS1 promoted GC cell proliferation, migration, invasion, and epithelial–mesenchymal transition (EMT) and induced tumour growth in vivo. THUMPD3-AS1 regulated BCAT1 by competitively binding to miR-1297; further analyses revealed that both THUMPD3-AS1 and miR-1297 can interact with BCAT1. Conclusions These findings demonstrate that THUMPD3-AS1 promotes GC cell invasion and EMT via the miR-1297/BCAT1 pathway, suggesting that THUMPD3-AS1 is a novel biomarker and therapeutic target for GC." @default.
- W4367676831 created "2023-05-03" @default.
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- W4367676831 date "2023-05-02" @default.
- W4367676831 modified "2023-10-18" @default.
- W4367676831 title "LncRNA THUMPD3-AS1 promotes invasion and EMT in gastric cancer by regulating the miR-1297/BCAT1 pathway" @default.
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- W4367676831 doi "https://doi.org/10.21203/rs.3.rs-2844756/v1" @default.
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