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- W4367678610 endingPage "123005" @default.
- W4367678610 startingPage "123005" @default.
- W4367678610 abstract "HIV/AIDS remains a major global public health issue. While antiretroviral therapy is effective at reducing the viral load in the blood, up to 50% of those with HIV suffer from some degree of HIV-associated neurocognitive disorder, due to the presence of the blood–brain barrier restricting drugs from crossing into the central nervous system and treating the viral reservoir there. One way to circumvent this is the nose-to-brain pathway. This pathway can also be accessed via a facial intradermal injection. Certain parameters can increase delivery via this route, including using nanoparticles with a positive zeta potential and an effective diameter of 200 nm or less. Microneedle arrays offer a minimally invasive, pain-free alternative to traditional hypodermic injections. This study shows the formulation of nanocrystals of both rilpivirine (RPV) and cabotegravir, followed by incorporation into separate microneedle delivery systems for application to either side of the face. Following an in vivo study in rats, delivery to the brain was seen for both drugs. For RPV, a Cmax was seen at 21 days of 619.17 ± 73.32 ng/g, above that of recognised plasma IC90 levels, and potentially therapeutically relevant levels were maintained for 28 days. For CAB, a Cmax was seen at 28 days of 478.31 ± 320.86 ng/g, and while below recognised 4IC90 levels, does indicate that therapeutically relevant levels could be achieved by manipulating final microaaray patch size in humans." @default.
- W4367678610 created "2023-05-03" @default.
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- W4367678610 date "2023-06-01" @default.
- W4367678610 modified "2023-10-16" @default.
- W4367678610 title "Formulation of antiretroviral nanocrystals and development into a microneedle delivery system for potential treatment of HIV-associated neurocognitive disorder (HAND)" @default.
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- W4367678610 cites W1814881797 @default.
- W4367678610 cites W1832431255 @default.
- W4367678610 cites W1858140691 @default.
- W4367678610 cites W1935968253 @default.
- W4367678610 cites W1996719014 @default.
- W4367678610 cites W2012086312 @default.
- W4367678610 cites W2012594431 @default.
- W4367678610 cites W2015109242 @default.
- W4367678610 cites W2030950703 @default.
- W4367678610 cites W2034224323 @default.
- W4367678610 cites W2036070626 @default.
- W4367678610 cites W2058227083 @default.
- W4367678610 cites W2061215349 @default.
- W4367678610 cites W2063309056 @default.
- W4367678610 cites W2087675984 @default.
- W4367678610 cites W2098329282 @default.
- W4367678610 cites W2106408660 @default.
- W4367678610 cites W2112920381 @default.
- W4367678610 cites W2113945122 @default.
- W4367678610 cites W2115533786 @default.
- W4367678610 cites W2120063106 @default.
- W4367678610 cites W2132349584 @default.
- W4367678610 cites W2145480291 @default.
- W4367678610 cites W2150903174 @default.
- W4367678610 cites W2160760798 @default.
- W4367678610 cites W2186047168 @default.
- W4367678610 cites W2380988490 @default.
- W4367678610 cites W2395339327 @default.
- W4367678610 cites W2411771969 @default.
- W4367678610 cites W2463904583 @default.
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- W4367678610 cites W2531572956 @default.
- W4367678610 cites W2531808727 @default.
- W4367678610 cites W2587861573 @default.
- W4367678610 cites W2611603946 @default.
- W4367678610 cites W2613954206 @default.
- W4367678610 cites W2747771949 @default.
- W4367678610 cites W2766733089 @default.
- W4367678610 cites W2768413943 @default.
- W4367678610 cites W2790446992 @default.
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- W4367678610 cites W2795546193 @default.
- W4367678610 cites W2804592477 @default.
- W4367678610 cites W2805440312 @default.
- W4367678610 cites W2898571778 @default.
- W4367678610 cites W2899375051 @default.
- W4367678610 cites W2942085536 @default.
- W4367678610 cites W2945672866 @default.
- W4367678610 cites W2972898444 @default.
- W4367678610 cites W2982008052 @default.
- W4367678610 cites W3009983369 @default.
- W4367678610 cites W3024872581 @default.
- W4367678610 cites W3030616052 @default.
- W4367678610 cites W3037379202 @default.
- W4367678610 cites W3043062243 @default.
- W4367678610 cites W3116236574 @default.
- W4367678610 cites W3116486046 @default.
- W4367678610 cites W3126721121 @default.
- W4367678610 cites W3143014502 @default.
- W4367678610 cites W3161427380 @default.
- W4367678610 cites W3164445787 @default.
- W4367678610 cites W3165453365 @default.
- W4367678610 cites W3166762075 @default.
- W4367678610 cites W3170503105 @default.
- W4367678610 cites W3191732739 @default.
- W4367678610 cites W3192551162 @default.
- W4367678610 cites W3210148104 @default.
- W4367678610 cites W3213170848 @default.
- W4367678610 cites W4206166381 @default.
- W4367678610 cites W4214878311 @default.
- W4367678610 cites W4220832129 @default.
- W4367678610 cites W4224272817 @default.
- W4367678610 cites W4232913888 @default.
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- W4367678610 cites W4293221161 @default.
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- W4367678610 doi "https://doi.org/10.1016/j.ijpharm.2023.123005" @default.
- W4367678610 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37142137" @default.
- W4367678610 hasPublicationYear "2023" @default.
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