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- W4367678857 abstract "Delay discounting is linked to developmental trajectories of cognition and the brain, as well as psychopathology, such as psychosis. Although childhood socioeconomic deprivation is associated with both increased delay discounting and a higher incidence of psychotic disorders, the genetic and neural basis of these associations remains unclear. This study examined the causal relationships between neighborhood socioeconomic deprivation, delay discounting, and psychotic-like experiences (PLEs) in 2,135 preadolescent children using machine learning-based causal inference methods. We found that neighborhood deprivation, as measured by the Area Deprivation Index, had significant causal effects on delay discounting (β= -1.7297, p-FDR= 0.0258) and 1-year and 2-year follow-up PLEs (β= 1.3425~1.8721, p-FDR≤ 0.0291). Furthermore, our analysis revealed significant heterogeneous causal effects of neighborhood deprivation on PLEs (p-FDR<0.005). The subgroups most vulnerable to these causal effects exhibited steeper discounting of future rewards, higher polygenic scores for educational attainment, reduced structural volume/area/white matter in the parahippocampal, right temporal pole, and right pars opercularis, and greater functional activation in the limbic system during Monetary Incentives Delay tasks. Our findings highlight the importance of a bioecological framework and the involvement of the mesocorticolimbic system in the causal relationship between socioeconomic deprivation and the risk of psychosis during childhood. Overall, our results support that enhancing the residential socioeconomic environment could positively influence child development." @default.
- W4367678857 created "2023-05-03" @default.
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- W4367678857 date "2023-05-01" @default.
- W4367678857 modified "2023-09-26" @default.
- W4367678857 title "Heterogeneity in the Effects of Neighborhood Deprivation on Economic Decision Making and Mental Health in Children" @default.
- W4367678857 doi "https://doi.org/10.1101/2023.04.30.23289335" @default.
- W4367678857 hasPublicationYear "2023" @default.
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