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• W4367678899 abstract "Objective: This study aimed to elucidate the underlying gene regions responsible for productive, phenotypic or adaptive traits in different ecological types of Tibetan sheep and the discovery of important genes encoding valuable traits.Methods: We used whole-genome resequencing to explore the genetic relationships, phylogenetic tree, and population genetic structure analysis. In addition, we identified 28 representative Tibetan sheep single-nucleotide polymorphisms (SNPs) and genomic selective sweep regions with different traits in Tibetan sheep by fixation index (Fst) and the nucleotide diversity (θπ) ratio.Results: The genetic relationships analysis showed that each breed partitioned into its own clades and had close genetic relationships. We also identified many potential breed-specific selective sweep regions, including genes associated with hypoxic adaptability (<i>MTOR</i>, <i>TRHDE</i>, <i>PDK1</i>, <i>PTPN9</i>, <i>TMTC2</i>, <i>SOX9</i>, <i>EPAS1</i>, <i>PDGFD</i>, <i>SOCS3</i>, <i>TGFBR3</i>), coat color (<i>MITF</i>, <i>MC1R</i>, <i>ERCC2</i>, <i>TCF25</i>, <i>ITCH</i>, <i>TYR</i>, <i>RALY</i>, <i>KIT</i>), wool traits (<i>COL4A2</i>, <i>ERC2</i>, <i>NOTCH2</i>, <i>ROCK1</i>, <i>FGF5</i>, <i>SOX9</i>), and horn phenotypes (<i>RXFP2</i>). In particular, a horn-related gene, <i>RXFP2</i>, showed the four most significantly associated SNP loci (g. 29481646 A>G, g. 29469024 T>C, g. 29462010 C>T, g. 29461968 C>T) and haplotypes.Conclusion: This finding demonstrates the potential for genetic markers in future molecular breeding programs to improve selection for horn phenotypes. The results will facilitate the understanding of the genetic basis of production and adaptive unique traits in Chinese indigenous Tibetan sheep taxa and offer a reference for the molecular breeding of Tibetan sheep." @default.
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• W4367678899 date "2023-07-01" @default.
• W4367678899 modified "2023-10-14" @default.
• W4367678899 title "Genetic diversity and selection of Tibetan sheep breeds revealed by whole-genome resequencing" @default.
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• W4367678899 doi "https://doi.org/10.5713/ab.22.0432" @default.
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• W4367678899 hasPublicationYear "2023" @default.
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