FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4367692365> ?p ?o ?g. }

• W4367692365 endingPage "115438" @default.
• W4367692365 startingPage "115438" @default.
• W4367692365 abstract "Dried blood spot (DBS) sampling has evolved to become the method of choice for collecting samples for newborn screening and therapeutic drug monitoring worldwide. The major advantage of this approach is that it requires only a small amount of blood. In addition, the collection of DBSs on filter paper is simple, sample storage costs are small, and the process deactivates microorganisms and viruses. However, despite these advantages, DBS sampling is seldom used in forensic toxicological analyses. Here, we developed and validated an approach that uses liquid chromatography coupled with electrospray ionization-tandem mass spectrometry for quantifying nine psychotropic drugs (citalopram, duloxetine, mirtazapine, olanzapine, paroxetine, quetiapine, sertraline, zolpidem and zopiclone) in cadaveric DBS samples. Most of them are frequently used by self-harm but are not already targeted by an existing drug screening kit. Our method use only one 3-mm disk excised from each DBS and does not require the troublesome purification process. The linearities of the calibration curves were good in the concentration range of 0.05-1.0 μg/mL. Our method allows for repeatable and accurate quantification with intra- and inter-assay coefficients of variation of below 11.9% and below 12.5%, respectively, for each of the target drugs. In addition, the target drug concentrations in the DBSs remained stable for at least one month when stored at - 80 °C. Compared with our institute's routine method for cadaveric blood sampling, the QuEChERS method, quantifiable concentrations showed a good positive correlation for each of the target drugs. In addition, the concentrations of almost all the target drugs obtained with DBS sampling method were comparable with those obtained with the QuEChERS sampling method. Thus, the present findings extend the possible uses of DBS sampling to the quantification of multiple psychotropic drugs in the field of forensic toxicological testing." @default.
• W4367692365 created "2023-05-03" @default.
• W4367692365 creator A5007844965 @default.
• W4367692365 creator A5008648343 @default.
• W4367692365 creator A5027012857 @default.
• W4367692365 creator A5056309388 @default.
• W4367692365 creator A5070923150 @default.
• W4367692365 date "2023-09-01" @default.
• W4367692365 modified "2023-10-10" @default.
• W4367692365 title "Quantification of nine psychotropic drugs in postmortem dried blood spot samples by liquid chromatography–tandem mass spectrometry for simple toxicological analysis" @default.
• W4367692365 cites W1700762969 @default.
• W4367692365 cites W1951691066 @default.
• W4367692365 cites W2007501521 @default.
• W4367692365 cites W2028688348 @default.
• W4367692365 cites W2065244409 @default.
• W4367692365 cites W2073385148 @default.
• W4367692365 cites W2148671901 @default.
• W4367692365 cites W2152466948 @default.
• W4367692365 cites W2175531768 @default.
• W4367692365 cites W2530677056 @default.
• W4367692365 cites W2899702960 @default.
• W4367692365 cites W2920587468 @default.
• W4367692365 cites W2932723690 @default.
• W4367692365 cites W2943447960 @default.
• W4367692365 cites W2960480716 @default.
• W4367692365 cites W3037659265 @default.
• W4367692365 cites W3175334346 @default.
• W4367692365 cites W3200568586 @default.
• W4367692365 cites W3213980595 @default.
• W4367692365 cites W4240389001 @default.
• W4367692365 cites W4313312052 @default.
• W4367692365 doi "https://doi.org/10.1016/j.jpba.2023.115438" @default.
• W4367692365 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37167768" @default.
• W4367692365 hasPublicationYear "2023" @default.
• W4367692365 type Work @default.
• W4367692365 citedByCount "1" @default.
• W4367692365 countsByYear W43676923652023 @default.
• W4367692365 crossrefType "journal-article" @default.
• W4367692365 hasAuthorship W4367692365A5007844965 @default.
• W4367692365 hasAuthorship W4367692365A5008648343 @default.
• W4367692365 hasAuthorship W4367692365A5027012857 @default.
• W4367692365 hasAuthorship W4367692365A5056309388 @default.
• W4367692365 hasAuthorship W4367692365A5070923150 @default.
• W4367692365 hasConcept C137535248 @default.
• W4367692365 hasConcept C158342456 @default.
• W4367692365 hasConcept C162356407 @default.
• W4367692365 hasConcept C185592680 @default.
• W4367692365 hasConcept C2776597655 @default.
• W4367692365 hasConcept C2780035454 @default.
• W4367692365 hasConcept C2780272996 @default.
• W4367692365 hasConcept C3017516299 @default.
• W4367692365 hasConcept C31827203 @default.
• W4367692365 hasConcept C43617362 @default.
• W4367692365 hasConcept C71924100 @default.
• W4367692365 hasConcept C98274493 @default.
• W4367692365 hasConceptScore W4367692365C137535248 @default.
• W4367692365 hasConceptScore W4367692365C158342456 @default.
• W4367692365 hasConceptScore W4367692365C162356407 @default.
• W4367692365 hasConceptScore W4367692365C185592680 @default.
• W4367692365 hasConceptScore W4367692365C2776597655 @default.
• W4367692365 hasConceptScore W4367692365C2780035454 @default.
• W4367692365 hasConceptScore W4367692365C2780272996 @default.
• W4367692365 hasConceptScore W4367692365C3017516299 @default.
• W4367692365 hasConceptScore W4367692365C31827203 @default.
• W4367692365 hasConceptScore W4367692365C43617362 @default.
• W4367692365 hasConceptScore W4367692365C71924100 @default.
• W4367692365 hasConceptScore W4367692365C98274493 @default.
• W4367692365 hasFunder F4320334764 @default.
• W4367692365 hasLocation W43676923651 @default.
• W4367692365 hasLocation W43676923652 @default.
• W4367692365 hasOpenAccess W4367692365 @default.
• W4367692365 hasPrimaryLocation W43676923651 @default.
• W4367692365 hasRelatedWork W1486309521 @default.
• W4367692365 hasRelatedWork W2001515052 @default.
• W4367692365 hasRelatedWork W2039159829 @default.
• W4367692365 hasRelatedWork W2053246531 @default.
• W4367692365 hasRelatedWork W2139802092 @default.
• W4367692365 hasRelatedWork W2154583443 @default.
• W4367692365 hasRelatedWork W2806487880 @default.
• W4367692365 hasRelatedWork W2915370732 @default.
• W4367692365 hasRelatedWork W3156435294 @default.
• W4367692365 hasRelatedWork W4367692365 @default.
• W4367692365 hasVolume "233" @default.
• W4367692365 isParatext "false" @default.
• W4367692365 isRetracted "false" @default.
• W4367692365 workType "article" @default.