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- W4367693312 endingPage "100595" @default.
- W4367693312 startingPage "100595" @default.
- W4367693312 abstract "Leptospirosis is a neglected bacterial disease caused by leptospiral infection that carries a substantial mortality risk in severe cases. Research has shown that acute, chronic, and asymptomatic leptospiral infections are closely linked to acute and chronic kidney disease and renal fibrosis. Leptospires affect renal function by infiltrating kidney cells via the renal tubules and interstitium and surviving in the kidney by circumventing the immune system. The most well-known pathogenic molecular mechanism of renal tubular damage caused by leptospiral infection is the direct binding of the bacterial outer membrane protein LipL32 to toll-like receptor-2 expressed in renal tubular epithelial cells to induce intracellular inflammatory signaling pathways. These pathways include the production of tumor necrosis factor-α and nuclear factor kappa activation, resulting in acute and chronic leptospirosis-related kidney injury. Few studies have investigated the relationship between acute and chronic renal diseases and leptospirosis and further evidence is necessary. In this review, we intend to discuss the roles of acute kidney injury to/on chronic kidney disease in leptospirosis. This study reviews the molecular pathways underlying the pathogenesis of leptospirosis kidney disease, which will assist in concentrating on potential future research directions." @default.
- W4367693312 created "2023-05-03" @default.
- W4367693312 creator A5000500792 @default.
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- W4367693312 creator A5052789941 @default.
- W4367693312 creator A5053290346 @default.
- W4367693312 creator A5074241993 @default.
- W4367693312 creator A5076785998 @default.
- W4367693312 date "2023-08-01" @default.
- W4367693312 modified "2023-10-14" @default.
- W4367693312 title "Leptospirosis kidney disease: Evolution from acute to chronic kidney disease" @default.
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