FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4367693856> ?p ?o ?g. }

• W4367693856 abstract "Individualized prediction of treatment response may improve the value proposition of advanced treatment options in severe asthma. This study aimed to investigate the combined capacity of patient characteristics in predicting treatment response to mepolizumab in patients with severe asthma.Patient-level data were pooled from two multinational phase 3 trials of mepolizumab in severe eosinophilic asthma. We fitted penalized regression models to quantify reductions in the rate of severe exacerbations and the 5-item Asthma Control Questionnaire (ACQ5) score. The capacity of 15 covariates towards predicting treatment response was quantified by the Gini index (measuring disparities in treatment benefit) as well as observed treatment benefit within the quintiles of predicted treatment benefit.There was marked variability in the ability of patient characteristics to predict treatment response; covariates explained greater heterogeneity in predicting treatment response to asthma control than to exacerbation frequency (Gini index 0.35 v. 0.24). Key predictors for treatment benefit for severe exacerbations included exacerbation history, blood eosinophil count, baseline ACQ5 score and age, and those for symptom control included blood eosinophil count and presence of nasal polyps. Overall, the average reduction in exacerbations was 0.90/year (95%CI, 0.87‒0.92) and average reduction in ACQ5 score was 0.18 (95% CI, 0.02‒0.35). Among the top 20% of patients for predicted treatment benefit, exacerbations were reduced by 2.23/year (95% CI, 2.03‒2.43) and ACQ5 score were reduced by 0.59 (95% CI, 0.19‒0.98). Among the bottom 20% of patients for predicted treatment benefit, exacerbations were reduced by 0.25/year (95% CI, 0.16‒0.34) and ACQ5 by -0.20 (95% CI, -0.51 to 0.11).A precision medicine approach based on multiple patient characteristics can guide biologic therapy in severe asthma, especially in identifying patients who will not benefit as much from therapy. Patient characteristics had a greater capacity to predict treatment response to asthma control than to exacerbation.ClinicalTrials.gov number, NCT01691521 (registered September 24, 2012) and NCT01000506 (registered October 23, 2009)." @default.
• W4367693856 created "2023-05-03" @default.
• W4367693856 creator A5011926591 @default.
• W4367693856 creator A5018077929 @default.
• W4367693856 creator A5030571912 @default.
• W4367693856 creator A5046972409 @default.
• W4367693856 creator A5054105827 @default.
• W4367693856 creator A5077449354 @default.
• W4367693856 date "2023-05-02" @default.
• W4367693856 modified "2023-09-26" @default.
• W4367693856 title "Can we predict who will benefit most from biologics in severe asthma? A post-hoc analysis of two phase 3 trials" @default.
• W4367693856 cites W1984208669 @default.
• W4367693856 cites W1988758075 @default.
• W4367693856 cites W2019613010 @default.
• W4367693856 cites W2039439214 @default.
• W4367693856 cites W2050815733 @default.
• W4367693856 cites W2062918919 @default.
• W4367693856 cites W2068966334 @default.
• W4367693856 cites W2075699130 @default.
• W4367693856 cites W2094189191 @default.
• W4367693856 cites W2095754126 @default.
• W4367693856 cites W2098276532 @default.
• W4367693856 cites W2128690134 @default.
• W4367693856 cites W2138355864 @default.
• W4367693856 cites W2141019416 @default.
• W4367693856 cites W2144795809 @default.
• W4367693856 cites W2481291932 @default.
• W4367693856 cites W2601675613 @default.
• W4367693856 cites W2601782539 @default.
• W4367693856 cites W2619633721 @default.
• W4367693856 cites W2752584372 @default.
• W4367693856 cites W2767743996 @default.
• W4367693856 cites W2805002966 @default.
• W4367693856 cites W2901500377 @default.
• W4367693856 cites W2904040183 @default.
• W4367693856 cites W2914302947 @default.
• W4367693856 cites W2944263065 @default.
• W4367693856 cites W2952356497 @default.
• W4367693856 cites W2974893662 @default.
• W4367693856 cites W2976149101 @default.
• W4367693856 cites W3009509122 @default.
• W4367693856 cites W3012413426 @default.
• W4367693856 cites W3027043096 @default.
• W4367693856 cites W3092750233 @default.
• W4367693856 cites W3093042321 @default.
• W4367693856 cites W4205763276 @default.
• W4367693856 cites W4289527896 @default.
• W4367693856 cites W4306957267 @default.
• W4367693856 doi "https://doi.org/10.1186/s12931-023-02409-2" @default.
• W4367693856 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37131185" @default.
• W4367693856 hasPublicationYear "2023" @default.
• W4367693856 type Work @default.
• W4367693856 citedByCount "1" @default.
• W4367693856 countsByYear W43676938562023 @default.
• W4367693856 crossrefType "journal-article" @default.
• W4367693856 hasAuthorship W4367693856A5011926591 @default.
• W4367693856 hasAuthorship W4367693856A5018077929 @default.
• W4367693856 hasAuthorship W4367693856A5030571912 @default.
• W4367693856 hasAuthorship W4367693856A5046972409 @default.
• W4367693856 hasAuthorship W4367693856A5054105827 @default.
• W4367693856 hasAuthorship W4367693856A5077449354 @default.
• W4367693856 hasBestOaLocation W43676938561 @default.
• W4367693856 hasConcept C126322002 @default.
• W4367693856 hasConcept C1862650 @default.
• W4367693856 hasConcept C2776042228 @default.
• W4367693856 hasConcept C2777014857 @default.
• W4367693856 hasConcept C2777037409 @default.
• W4367693856 hasConcept C2777832160 @default.
• W4367693856 hasConcept C67761136 @default.
• W4367693856 hasConcept C71924100 @default.
• W4367693856 hasConceptScore W4367693856C126322002 @default.
• W4367693856 hasConceptScore W4367693856C1862650 @default.
• W4367693856 hasConceptScore W4367693856C2776042228 @default.
• W4367693856 hasConceptScore W4367693856C2777014857 @default.
• W4367693856 hasConceptScore W4367693856C2777037409 @default.
• W4367693856 hasConceptScore W4367693856C2777832160 @default.
• W4367693856 hasConceptScore W4367693856C67761136 @default.
• W4367693856 hasConceptScore W4367693856C71924100 @default.
• W4367693856 hasIssue "1" @default.
• W4367693856 hasLocation W43676938561 @default.
• W4367693856 hasLocation W43676938562 @default.
• W4367693856 hasLocation W43676938563 @default.
• W4367693856 hasLocation W43676938564 @default.
• W4367693856 hasLocation W43676938565 @default.
• W4367693856 hasOpenAccess W4367693856 @default.
• W4367693856 hasPrimaryLocation W43676938561 @default.
• W4367693856 hasRelatedWork W1965484089 @default.
• W4367693856 hasRelatedWork W1967519791 @default.
• W4367693856 hasRelatedWork W2002613275 @default.
• W4367693856 hasRelatedWork W2089505012 @default.
• W4367693856 hasRelatedWork W2324038222 @default.
• W4367693856 hasRelatedWork W2565464084 @default.
• W4367693856 hasRelatedWork W2900807093 @default.
• W4367693856 hasRelatedWork W4237080550 @default.
• W4367693856 hasRelatedWork W4280546035 @default.
• W4367693856 hasRelatedWork W1949704877 @default.
• W4367693856 hasVolume "24" @default.
• W4367693856 isParatext "false" @default.
• W4367693856 isRetracted "false" @default.
• W4367693856 workType "article" @default.