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- W4367834215 abstract "Abstract Methionine restriction (MR) provides metabolic benefits in many organisms. However, mechanisms underlying the MR-induced effect remain incompletely understood. Here, we show in the budding yeast S. cerevisiae that MR relays a signal of S-adenosylmethionine (SAM) deprivation to adapt bioenergetic mitochondria to nitrogenic anabolism. In particular, decreases in cellular SAM constrain lipoate metabolism and protein lipoylation required for the operation of the tricarboxylic acid (TCA) cycle in the mitochondria, leading to incomplete glucose oxidation with an exit of acetyl-CoA and α-ketoglutarate from the TCA cycle to the syntheses of amino acids, such as arginine and leucine. This mitochondrial response achieves a trade-off between energy metabolism and nitrogenic anabolism, which serves as an effector mechanism promoting cell survival under MR." @default.
- W4367834215 created "2023-05-04" @default.
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- W4367834215 date "2023-05-02" @default.
- W4367834215 modified "2023-10-17" @default.
- W4367834215 title "Methionine restriction constrains lipoylation and activates mitochondria for nitrogenic synthesis of amino acids" @default.
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- W4367834215 doi "https://doi.org/10.1038/s41467-023-38289-9" @default.
- W4367834215 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37130856" @default.
- W4367834215 hasPublicationYear "2023" @default.
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