Matches in SemOpenAlex for { <https://semopenalex.org/work/W4367834476> ?p ?o ?g. }
- W4367834476 endingPage "e0281496" @default.
- W4367834476 startingPage "e0281496" @default.
- W4367834476 abstract "Diabetes mellitus (DM) is one of the most researched metabolic diseases worldwide. It leads to extensive complications such as cardiovascular disease, nephropathy, retinopathy, and peripheral and central nervous system through an inability to produce or respond to insulin. Although oxidative stress-mediated mitophagy has been reported to play an important role in the pathogenesis of DM, specific studies are still lacking as well as remain highly controversial. Here, we found that Parkin-mediated mitophagy in pancreatic β cells under streptozotocin (STZ)-diabetic stress was induced by Polo-like kinase 3 (Plk3) and inhibited by the transcription factor Forkhead Box O3A (FOXO3A). STZ stress induces mitochondrial recruitment of Parkin through Plk3-mediated mitochondrial reactive oxygen species (ROS) generation, which causes pancreatic cell damage. Conversely, FOXO3A acts as negative feedback to prevent diabetic stress by inhibiting Plk3. Meanwhile, antioxidants including N-acetylcysteine (NAC) and natural COA water scientifically block these mitochondrial ROS and mitochondrial recruitment of Parkin by inhibiting Plk3. Through a 3D organoid ex vivo model, we confirmed that not only ROS inhibitors but also mitophagy inhibitory factors such as 3-MA or Parkin deletion can compensate for pancreatic cell growth and insulin secretion under STZ diabetic stress. These findings suggest that the Plk3-mtROS-PINK1-Parkin axis is a novel mitophagy process that inhibits pancreatic β-cell growth and insulin secretion and FOXO3A and antioxidants may provide new alternatives for effective diabetes treatment strategies in the future." @default.
- W4367834476 created "2023-05-04" @default.
- W4367834476 creator A5001313680 @default.
- W4367834476 creator A5025104101 @default.
- W4367834476 creator A5034332797 @default.
- W4367834476 creator A5038855474 @default.
- W4367834476 creator A5083200567 @default.
- W4367834476 creator A5084416331 @default.
- W4367834476 creator A5089182235 @default.
- W4367834476 creator A5089812218 @default.
- W4367834476 date "2023-05-03" @default.
- W4367834476 modified "2023-10-14" @default.
- W4367834476 title "Parkin-mediated mitophagy is negatively regulated by FOXO3A, which inhibits Plk3-mediated mitochondrial ROS generation in STZ diabetic stress-treated pancreatic β cells" @default.
- W4367834476 cites W1902591710 @default.
- W4367834476 cites W1970840679 @default.
- W4367834476 cites W1976422365 @default.
- W4367834476 cites W1988519907 @default.
- W4367834476 cites W1992454850 @default.
- W4367834476 cites W2016839547 @default.
- W4367834476 cites W2018559323 @default.
- W4367834476 cites W2019750418 @default.
- W4367834476 cites W2023536633 @default.
- W4367834476 cites W2032474599 @default.
- W4367834476 cites W2044437167 @default.
- W4367834476 cites W2055807959 @default.
- W4367834476 cites W2074076323 @default.
- W4367834476 cites W2077467622 @default.
- W4367834476 cites W2092769218 @default.
- W4367834476 cites W2096317893 @default.
- W4367834476 cites W2105731956 @default.
- W4367834476 cites W2106444069 @default.
- W4367834476 cites W2143843448 @default.
- W4367834476 cites W2560781586 @default.
- W4367834476 cites W2565255170 @default.
- W4367834476 cites W2792165556 @default.
- W4367834476 cites W2897364906 @default.
- W4367834476 cites W2904914030 @default.
- W4367834476 cites W2915285292 @default.
- W4367834476 cites W2938976787 @default.
- W4367834476 cites W2964744158 @default.
- W4367834476 cites W2976585399 @default.
- W4367834476 cites W2998281421 @default.
- W4367834476 cites W3007238138 @default.
- W4367834476 cites W3007300319 @default.
- W4367834476 cites W3024085885 @default.
- W4367834476 cites W3040646360 @default.
- W4367834476 cites W3069202567 @default.
- W4367834476 cites W3107667427 @default.
- W4367834476 cites W3202321064 @default.
- W4367834476 cites W4206430225 @default.
- W4367834476 cites W4210654340 @default.
- W4367834476 cites W4220865863 @default.
- W4367834476 cites W4281878587 @default.
- W4367834476 cites W4285732712 @default.
- W4367834476 doi "https://doi.org/10.1371/journal.pone.0281496" @default.
- W4367834476 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37134105" @default.
- W4367834476 hasPublicationYear "2023" @default.
- W4367834476 type Work @default.
- W4367834476 citedByCount "0" @default.
- W4367834476 crossrefType "journal-article" @default.
- W4367834476 hasAuthorship W4367834476A5001313680 @default.
- W4367834476 hasAuthorship W4367834476A5025104101 @default.
- W4367834476 hasAuthorship W4367834476A5034332797 @default.
- W4367834476 hasAuthorship W4367834476A5038855474 @default.
- W4367834476 hasAuthorship W4367834476A5083200567 @default.
- W4367834476 hasAuthorship W4367834476A5084416331 @default.
- W4367834476 hasAuthorship W4367834476A5089182235 @default.
- W4367834476 hasAuthorship W4367834476A5089812218 @default.
- W4367834476 hasBestOaLocation W43678344761 @default.
- W4367834476 hasConcept C126322002 @default.
- W4367834476 hasConcept C134018914 @default.
- W4367834476 hasConcept C190283241 @default.
- W4367834476 hasConcept C203522944 @default.
- W4367834476 hasConcept C2776151105 @default.
- W4367834476 hasConcept C2776804853 @default.
- W4367834476 hasConcept C2777668072 @default.
- W4367834476 hasConcept C2779134260 @default.
- W4367834476 hasConcept C2779324830 @default.
- W4367834476 hasConcept C2779734285 @default.
- W4367834476 hasConcept C28859421 @default.
- W4367834476 hasConcept C502942594 @default.
- W4367834476 hasConcept C55493867 @default.
- W4367834476 hasConcept C71924100 @default.
- W4367834476 hasConcept C86803240 @default.
- W4367834476 hasConcept C95444343 @default.
- W4367834476 hasConceptScore W4367834476C126322002 @default.
- W4367834476 hasConceptScore W4367834476C134018914 @default.
- W4367834476 hasConceptScore W4367834476C190283241 @default.
- W4367834476 hasConceptScore W4367834476C203522944 @default.
- W4367834476 hasConceptScore W4367834476C2776151105 @default.
- W4367834476 hasConceptScore W4367834476C2776804853 @default.
- W4367834476 hasConceptScore W4367834476C2777668072 @default.
- W4367834476 hasConceptScore W4367834476C2779134260 @default.
- W4367834476 hasConceptScore W4367834476C2779324830 @default.
- W4367834476 hasConceptScore W4367834476C2779734285 @default.
- W4367834476 hasConceptScore W4367834476C28859421 @default.
- W4367834476 hasConceptScore W4367834476C502942594 @default.
- W4367834476 hasConceptScore W4367834476C55493867 @default.