Matches in SemOpenAlex for { <https://semopenalex.org/work/W4367834892> ?p ?o ?g. }
- W4367834892 abstract "Abstract Stereochemical and skeletal complexity are particularly important vis‐à‐vis the cross‐talks between a small molecule and a complementary active site of a biological target. This intricate harmony is known to increase selectivity, reduce toxicity, and increase the success rate in clinical trials. Therefore, the development of novel strategies for establishing underrepresented chemical space that is rich in stereochemical and skeletal diversity is an important milestone in a drug discovery campaign. In this review, we discuss the evolution of interdisciplinary synthetic methodologies utilized in chemical biology and drug discovery that has revolutionized the discovery of first‐in‐class molecules over the last decade with an emphasis on complexity‐to‐diversity and pseudo‐natural product strategies as a remarkable toolbox for deciphering next‐generation therapeutics. We also report how these approaches dramatically revolutionized the discovery of novel chemical probes that target underrepresented biological space. We also highlight selected applications and discuss key opportunities offered by these tools and important synthetic strategies used for the construction of chemical spaces that are rich in skeletal and stereochemical diversity. We also provide insight on how the integration of these protocols has the promise of changing the drug discovery landscape." @default.
- W4367834892 created "2023-05-04" @default.
- W4367834892 creator A5000362575 @default.
- W4367834892 creator A5007902357 @default.
- W4367834892 creator A5017818160 @default.
- W4367834892 creator A5032144682 @default.
- W4367834892 creator A5040889253 @default.
- W4367834892 creator A5049364435 @default.
- W4367834892 creator A5057776156 @default.
- W4367834892 creator A5076975749 @default.
- W4367834892 creator A5077163402 @default.
- W4367834892 date "2023-06-12" @default.
- W4367834892 modified "2023-10-17" @default.
- W4367834892 title "Complexity‐to‐Diversity and Pseudo‐Natural Product Strategies as Powerful Platforms for Deciphering Next‐Generation Therapeutics" @default.
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