Matches in SemOpenAlex for { <https://semopenalex.org/work/W4367834897> ?p ?o ?g. }
- W4367834897 abstract "Abstract Organ fibrosis can occur in virtually all major organs with relentlessly progressive and irreversible progress, ultimately resulting in organ dysfunction and potentially death. Unfortunately, current clinical treatments cannot halt or reverse the progression of fibrosis to end-stage organ failure, and thus, advanced antifibrotic therapeutics are urgently needed. In recent years, a growing body of research has revealed that circular RNAs (circRNAs) play pivotal roles in the development and progression of organ fibrosis through highly diverse mechanisms of action. Thus, manipulating circRNAs has emerged as a promising strategy to mitigate fibrosis across different organ types. In this review, we systemically summarize the current state of knowledge about circRNA biological properties and the regulatory mechanisms of circRNAs. A comprehensive overview of major fibrotic signaling pathways and representative circRNAs that are known to modulate fibrotic signals are outlined. Then, we focus on the research progress of the versatile functional roles and underlying molecular mechanisms of circRNAs in various fibrotic diseases in different organs, including the heart, liver, lung, kidney and skin. Finally, we offer a glimpse into the prospects of circRNA-based interference and therapy, as well as their utilization as biomarkers in the diagnosis and prognosis of fibrotic diseases." @default.
- W4367834897 created "2023-05-04" @default.
- W4367834897 creator A5004923502 @default.
- W4367834897 creator A5018626803 @default.
- W4367834897 creator A5043225123 @default.
- W4367834897 creator A5044756293 @default.
- W4367834897 creator A5058497975 @default.
- W4367834897 date "2023-05-02" @default.
- W4367834897 modified "2023-10-14" @default.
- W4367834897 title "CircRNAs: versatile players and new targets in organ fibrosis" @default.
- W4367834897 cites W2058835062 @default.
- W4367834897 cites W2064165694 @default.
- W4367834897 cites W2803209940 @default.
- W4367834897 cites W2917695714 @default.
- W4367834897 cites W2928211142 @default.
- W4367834897 cites W2929661915 @default.
- W4367834897 cites W2942134847 @default.
- W4367834897 cites W2983634296 @default.
- W4367834897 cites W2997795180 @default.
- W4367834897 cites W3001086348 @default.
- W4367834897 cites W3004193861 @default.
- W4367834897 cites W3004292322 @default.
- W4367834897 cites W3006479394 @default.
- W4367834897 cites W3007189276 @default.
- W4367834897 cites W3015462378 @default.
- W4367834897 cites W3025043200 @default.
- W4367834897 cites W3037826277 @default.
- W4367834897 cites W3037863440 @default.
- W4367834897 cites W3040778371 @default.
- W4367834897 cites W3044734159 @default.
- W4367834897 cites W3046328041 @default.
- W4367834897 cites W3049289158 @default.
- W4367834897 cites W3082788835 @default.
- W4367834897 cites W3085038881 @default.
- W4367834897 cites W3087237288 @default.
- W4367834897 cites W3094909778 @default.
- W4367834897 cites W3106976801 @default.
- W4367834897 cites W3109793392 @default.
- W4367834897 cites W3110431679 @default.
- W4367834897 cites W3119921402 @default.
- W4367834897 cites W3121973832 @default.
- W4367834897 cites W3122226502 @default.
- W4367834897 cites W3122511155 @default.
- W4367834897 cites W3129915779 @default.
- W4367834897 cites W3130780556 @default.
- W4367834897 cites W3135108572 @default.
- W4367834897 cites W3153902912 @default.
- W4367834897 cites W3157784033 @default.
- W4367834897 cites W3160504883 @default.
- W4367834897 cites W3161409907 @default.
- W4367834897 cites W3164288225 @default.
- W4367834897 cites W3167722610 @default.
- W4367834897 cites W3177486724 @default.
- W4367834897 cites W3181344481 @default.
- W4367834897 cites W3181943740 @default.
- W4367834897 cites W3187167951 @default.
- W4367834897 cites W3191502309 @default.
- W4367834897 cites W3194704945 @default.
- W4367834897 cites W3214895416 @default.
- W4367834897 cites W4200074879 @default.
- W4367834897 cites W4205407513 @default.
- W4367834897 cites W4205739136 @default.
- W4367834897 cites W4206756645 @default.
- W4367834897 cites W4206983005 @default.
- W4367834897 cites W4210563368 @default.
- W4367834897 cites W4210828322 @default.
- W4367834897 cites W4212803602 @default.
- W4367834897 cites W4212820851 @default.
- W4367834897 cites W4213018448 @default.
- W4367834897 cites W4213223146 @default.
- W4367834897 cites W4214672451 @default.
- W4367834897 cites W4220863167 @default.
- W4367834897 cites W4220887069 @default.
- W4367834897 cites W4221048603 @default.
- W4367834897 cites W4221097003 @default.
- W4367834897 cites W4221131757 @default.
- W4367834897 cites W4223492085 @default.
- W4367834897 cites W4224304188 @default.
- W4367834897 cites W4225126704 @default.
- W4367834897 cites W4225146081 @default.
- W4367834897 cites W4225247750 @default.
- W4367834897 cites W4225435152 @default.
- W4367834897 cites W4226027283 @default.
- W4367834897 cites W4226063747 @default.
- W4367834897 cites W4226068899 @default.
- W4367834897 cites W4280638470 @default.
- W4367834897 cites W4281482071 @default.
- W4367834897 cites W4281911383 @default.
- W4367834897 cites W4281957575 @default.
- W4367834897 cites W4282550936 @default.
- W4367834897 cites W4283329981 @default.
- W4367834897 cites W4283581064 @default.
- W4367834897 cites W4283701080 @default.
- W4367834897 cites W4283746337 @default.
- W4367834897 cites W4283819321 @default.
- W4367834897 cites W4285034796 @default.
- W4367834897 cites W4285076418 @default.
- W4367834897 cites W4285155658 @default.
- W4367834897 cites W4285745184 @default.
- W4367834897 cites W4287377796 @default.