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- W4367840150 endingPage "113335" @default.
- W4367840150 startingPage "113335" @default.
- W4367840150 abstract "Glucose oxidase (GOD) exerts anticancer effects by producing hydrogen peroxide (H2O2). However, the use of GOD is limited by its short half-life and low stability. Systemic H2O2 production following systemic absorption of GOD can also cause serious toxicity. GOD-conjugated bovine serum albumin nanoparticles (GOD-BSA NPs) may be useful for overcoming these limitations. Here, bioorthogonal copper-free click chemistry was employed to develop GOD-BSA NPs that are non-toxic and biodegradable and can effectively and rapidly conjugate proteins. These NPs retained their activity, unlike conventional albumin NPs. NPs using dibenzyl cyclooctyne (DBCO)-modified albumin, azide-modified albumin, and azide-modified GOD were fabricated in 10 min. After intratumoral administration, GOD-BSA NPs remained in the tumor for a longer period and displayed better anticancer activity than the effects of GOD alone. GOD-BSA NPs were approximately 240 nm in size and inhibited tumor growth to 40 mm3, whereas tumors treated with phosphate-buffered saline or albumin NPs had sizes of 1673 and 1578 mm3, respectively. GOD-BSA NPs prepared using click chemistry may be useful as a drug delivery system for protein enzymes." @default.
- W4367840150 created "2023-05-04" @default.
- W4367840150 creator A5034008612 @default.
- W4367840150 date "2023-06-01" @default.
- W4367840150 modified "2023-09-27" @default.
- W4367840150 title "Click chemistry-based novel albumin nanoparticles for anticancer treatment via H2O2 generation" @default.
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- W4367840150 doi "https://doi.org/10.1016/j.colsurfb.2023.113335" @default.
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