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- W4367846994 abstract "Abstract The constant need for novel drugs has prompted the scientific community to explore alternative structures to natural products and small and medium size organic compounds used in classic medicinal and pharmaceutical chemistry. Since the discovery of cisplatin, organometallic compounds have revealed great potential as metallodrugs and their development has exponentially grown in recent years. In this manuscript, we describe our efforts towards the synthesis of new metallodrugs by reaction of bis(pyridyl)allenes and metal complexes. Two classes of compounds are presented: one in which the allene structure is intact and the metal (Pd(II), Pt(IV) or Au(III)) coordinates to the pyridine-nitrogens; and another, in which one of the pyridines cyclises into a gold-activated allene to form β-N-stabilised gold carbenes. Both classes of compounds are active catalysts in important organic reactions, and are also promising antimicrobial, antifungal and anticancer agents. In this work, we describe the promising anticancer activity, against breast cancer cells, of the gold carbene complexes, and preliminary studies of their interaction with DNA, including non-canonical DNA structures. Our results have revealed an unusual selective stabilisation of hTeloC i-motif by one of the Au(III) carbene complexes, that opens up exciting opportunities for further development of novel DNA-binding metallodrugs." @default.
- W4367846994 created "2023-05-04" @default.
- W4367846994 creator A5053952101 @default.
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- W4367846994 creator A5084646544 @default.
- W4367846994 date "2023-04-01" @default.
- W4367846994 modified "2023-09-26" @default.
- W4367846994 title "Anticancer activity and DNA interaction of bis(pyridyl)allene-derived metal complexes" @default.
- W4367846994 cites W1555009525 @default.
- W4367846994 cites W1612177578 @default.
- W4367846994 cites W1703829766 @default.
- W4367846994 cites W1709502500 @default.
- W4367846994 cites W1947171523 @default.
- W4367846994 cites W1963719070 @default.
- W4367846994 cites W1969499821 @default.
- W4367846994 cites W1974693247 @default.
- W4367846994 cites W1986145542 @default.
- W4367846994 cites W1986203922 @default.
- W4367846994 cites W1986406178 @default.
- W4367846994 cites W1990115398 @default.
- W4367846994 cites W1991279020 @default.
- W4367846994 cites W1992522098 @default.
- W4367846994 cites W1996952541 @default.
- W4367846994 cites W1998161685 @default.
- W4367846994 cites W2012076508 @default.
- W4367846994 cites W2014642352 @default.
- W4367846994 cites W2014966556 @default.
- W4367846994 cites W2017356685 @default.
- W4367846994 cites W2017688478 @default.
- W4367846994 cites W2022948223 @default.
- W4367846994 cites W2023182333 @default.
- W4367846994 cites W2028062187 @default.
- W4367846994 cites W2030976397 @default.
- W4367846994 cites W2033530592 @default.
- W4367846994 cites W2033805304 @default.
- W4367846994 cites W2034207473 @default.
- W4367846994 cites W2043515758 @default.
- W4367846994 cites W2047212216 @default.
- W4367846994 cites W2047572958 @default.
- W4367846994 cites W2049894763 @default.
- W4367846994 cites W2050724834 @default.
- W4367846994 cites W2059306569 @default.
- W4367846994 cites W2064894863 @default.
- W4367846994 cites W2065693646 @default.
- W4367846994 cites W2066105236 @default.
- W4367846994 cites W2072961231 @default.
- W4367846994 cites W2074139680 @default.
- W4367846994 cites W2074274985 @default.
- W4367846994 cites W2075980277 @default.
- W4367846994 cites W2081051815 @default.
- W4367846994 cites W2083227636 @default.
- W4367846994 cites W2089166081 @default.
- W4367846994 cites W2090488372 @default.
- W4367846994 cites W2090858808 @default.
- W4367846994 cites W2096095251 @default.
- W4367846994 cites W2101898479 @default.
- W4367846994 cites W2105669930 @default.
- W4367846994 cites W2123194667 @default.
- W4367846994 cites W2123527315 @default.
- W4367846994 cites W2126559170 @default.
- W4367846994 cites W2126730117 @default.
- W4367846994 cites W2142597103 @default.
- W4367846994 cites W2153647882 @default.
- W4367846994 cites W2164277862 @default.
- W4367846994 cites W2166302315 @default.
- W4367846994 cites W2167177339 @default.
- W4367846994 cites W2168810693 @default.
- W4367846994 cites W2234534890 @default.
- W4367846994 cites W2320434517 @default.
- W4367846994 cites W2339621158 @default.
- W4367846994 cites W2549524716 @default.
- W4367846994 cites W2561065388 @default.
- W4367846994 cites W2566191771 @default.
- W4367846994 cites W2566222996 @default.
- W4367846994 cites W2586727998 @default.
- W4367846994 cites W2605856867 @default.
- W4367846994 cites W2727412338 @default.
- W4367846994 cites W2733645645 @default.
- W4367846994 cites W2755897343 @default.
- W4367846994 cites W2792259017 @default.
- W4367846994 cites W2796120208 @default.
- W4367846994 cites W2802031420 @default.
- W4367846994 cites W2804132337 @default.
- W4367846994 cites W2889426706 @default.
- W4367846994 cites W2895214712 @default.
- W4367846994 cites W2896130004 @default.
- W4367846994 cites W2902760954 @default.
- W4367846994 cites W2909497765 @default.
- W4367846994 cites W2912406718 @default.
- W4367846994 cites W2946165729 @default.
- W4367846994 cites W2965941316 @default.
- W4367846994 cites W2994715302 @default.
- W4367846994 cites W3005921653 @default.
- W4367846994 cites W3084304176 @default.
- W4367846994 cites W3108219719 @default.
- W4367846994 cites W3127226111 @default.