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- W436795370 abstract "Objective To evaluate the clinical efficacy and safety of linezolid in the treatment of children with various kinds of infectious diseases composed mainly of respiratory infection. Methods Forty hospitalized children with infectious diseases were enrolled from March to September in 2008. Based on bacterial culture results or clinical experience, efficacy of linezolid was evaluated by means of retrospective analysis in different underlying diseases, infection sites and pathogens. Results The clinical cure rate, significant rate and none effective rate of 40 children were 70%, 27.5% and 2.5% respectively. The overall effective rate was 97.5% and there was no significant statistical difference between the clinical cure rate of different underlying diseases and infection sites. Twenty-six resistant gram-positive strains were detected in 40 children with pathogen eradication rate of 96.2%. The Linezolid course, positive symptoms and signs disappearing time of group with incipient usage of linezolid in 17 cured cases were shorter than those of group with ineffective treatment of vancomycin changed by linezolid later in 11 cured cases (P 0.05). The positive signs disappearing and bacterium eradication time of he group with bacterium originated from pulmonary in 10 cases were also shorter than those of the group from other sites in 15 cases(P 0.05). The main adverse reactions included diarrhea, skin rash and blood changes in 2 cases respectively and diarrhea plus skin rash in 1 case. Liver and renal function monitor shew no influence. Conclusion Linezolid is active against resistant gram-positive infections including vancomycin resistant enterococci in children with high pathogen eradication rate. With high penetrativity in tissues and fast efficacy for pulmonary infections, linezolid was one of the recommended choices of treatment for severe cases with gram-positive infections and the other cases with inefficacy and allergy to vancomycin. With reversible side effects and good tolerance, linezolid-treated patients in long-term usage should take hemogram, liver and renal function monitor." @default.
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- W436795370 date "2009-01-01" @default.
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- W436795370 title "Clinical efficacy analysis of Linezolid in treatment of 40 children with infectious diseases" @default.
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