Matches in SemOpenAlex for { <https://semopenalex.org/work/W4368348195> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W4368348195 abstract "The paradigm of drug delivery via nano- and microcarriers is one of the leading ideas that enable overcoming the limitations of traditional chemotherapy. The trend toward more complex drug carriers capable of multifunctionality is observed in the literature. To date, prospects of stimuli-responsive systems to control the cargo release in the lesion nidus are widely accepted. Both endogenous and exogenous stimuli are employed for this purpose, however, endogenous pH is one of the most common triggers. Unfortunately, scientists face difficulties in the implementation of this idea since a range of biological barriers, drug bioavailability issues, and challenges in the synthesis of carriers with required properties have arisen. Here, we discuss fundamental strategies of pH-responsive drug delivery as well as limits in its application and reveal the main problems, weak sides, and reasons for poor clinical results. Also, we have made an attempt to formulate the profiles of "ideal" drug carrier in the frame of different strategies and considered recently published studies through the lens of these profiles. This approach enables the identification of current trends and promising vectors in the development of pH-responsive drug delivery systems, as well as challenges to be resolved in the next generation of carriers." @default.
- W4368348195 created "2023-05-05" @default.
- W4368348195 creator A5018693476 @default.
- W4368348195 creator A5030583057 @default.
- W4368348195 creator A5041593279 @default.
- W4368348195 creator A5046517880 @default.
- W4368348195 creator A5047757593 @default.
- W4368348195 creator A5071369939 @default.
- W4368348195 date "2023-05-05" @default.
- W4368348195 modified "2023-10-14" @default.
- W4368348195 title "Current Principles, Challenges, and New Metrics in pH-Responsive Drug Delivery Systems for Systemic Cancer Therapy" @default.
- W4368348195 doi "https://doi.org/10.20944/preprints202305.0289.v1" @default.
- W4368348195 hasPublicationYear "2023" @default.
- W4368348195 type Work @default.
- W4368348195 citedByCount "0" @default.
- W4368348195 crossrefType "posted-content" @default.
- W4368348195 hasAuthorship W4368348195A5018693476 @default.
- W4368348195 hasAuthorship W4368348195A5030583057 @default.
- W4368348195 hasAuthorship W4368348195A5041593279 @default.
- W4368348195 hasAuthorship W4368348195A5046517880 @default.
- W4368348195 hasAuthorship W4368348195A5047757593 @default.
- W4368348195 hasAuthorship W4368348195A5071369939 @default.
- W4368348195 hasBestOaLocation W43683481951 @default.
- W4368348195 hasConcept C112930515 @default.
- W4368348195 hasConcept C121608353 @default.
- W4368348195 hasConcept C126322002 @default.
- W4368348195 hasConcept C127413603 @default.
- W4368348195 hasConcept C13245373 @default.
- W4368348195 hasConcept C171250308 @default.
- W4368348195 hasConcept C183696295 @default.
- W4368348195 hasConcept C192562407 @default.
- W4368348195 hasConcept C2779820397 @default.
- W4368348195 hasConcept C2780035454 @default.
- W4368348195 hasConcept C2983331546 @default.
- W4368348195 hasConcept C41008148 @default.
- W4368348195 hasConcept C71924100 @default.
- W4368348195 hasConcept C98274493 @default.
- W4368348195 hasConceptScore W4368348195C112930515 @default.
- W4368348195 hasConceptScore W4368348195C121608353 @default.
- W4368348195 hasConceptScore W4368348195C126322002 @default.
- W4368348195 hasConceptScore W4368348195C127413603 @default.
- W4368348195 hasConceptScore W4368348195C13245373 @default.
- W4368348195 hasConceptScore W4368348195C171250308 @default.
- W4368348195 hasConceptScore W4368348195C183696295 @default.
- W4368348195 hasConceptScore W4368348195C192562407 @default.
- W4368348195 hasConceptScore W4368348195C2779820397 @default.
- W4368348195 hasConceptScore W4368348195C2780035454 @default.
- W4368348195 hasConceptScore W4368348195C2983331546 @default.
- W4368348195 hasConceptScore W4368348195C41008148 @default.
- W4368348195 hasConceptScore W4368348195C71924100 @default.
- W4368348195 hasConceptScore W4368348195C98274493 @default.
- W4368348195 hasLocation W43683481951 @default.
- W4368348195 hasOpenAccess W4368348195 @default.
- W4368348195 hasPrimaryLocation W43683481951 @default.
- W4368348195 hasRelatedWork W132838605 @default.
- W4368348195 hasRelatedWork W2012478559 @default.
- W4368348195 hasRelatedWork W2026680301 @default.
- W4368348195 hasRelatedWork W2337597952 @default.
- W4368348195 hasRelatedWork W2405839080 @default.
- W4368348195 hasRelatedWork W2408703666 @default.
- W4368348195 hasRelatedWork W2900479635 @default.
- W4368348195 hasRelatedWork W2944439775 @default.
- W4368348195 hasRelatedWork W2948369049 @default.
- W4368348195 hasRelatedWork W3014835100 @default.
- W4368348195 isParatext "false" @default.
- W4368348195 isRetracted "false" @default.
- W4368348195 workType "article" @default.