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- W4368363603 abstract "Highly interconnected poly(lactic acid) (PLA)-based foams are extensively utilized to be candidate porous scaffolds in the field of tissue engineering. Nonetheless, it remains challenging about the preparation of highly porous, interconnected and hydrophilic PLA-based scaffolds through a facile and cheap method. The present work synthesized PLA-based scaffolds with high porosity through supercritical carbon dioxide (sc-CO2) foaming strategy. For improving PLA foam interconnection as well as hydrophilicity, poly(butylene succinate) (PBS), and poly(ethylene glycol) (PEG) were chosen to be excellent additives for PLA blending. PEG acted as a compatibilizer between PLA and PBS, which enhanced open cell structure generation by decreasing melt viscosity. According to investigation of PBS and PEG content as well as foaming temperature, PLA/PBS/PEG(90/10/10) blend foaming under 100°C had the greatest open cell rate of 95.9% and high volume expansion ratio of 13.98, meanwhile, its water contact angle reduced to 62.5°. In addition, the fibroblast NIH/3T3 cells with live/dead cell fluorescence staining assay was utilized to examine the biocompatibility of PLA-based scaffolds. Results indicated that the PLA/PBS/PEG scaffolds had better biocompatibility than PLA/PBS scaffolds. This work provides an easy and green approach for fabricating fully biodegradable PLA-based scaffolds with high open cell rate and hydrophilicity in tissue engineering." @default.
- W4368363603 created "2023-05-05" @default.
- W4368363603 creator A5050371381 @default.
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- W4368363603 date "2023-05-04" @default.
- W4368363603 modified "2023-10-01" @default.
- W4368363603 title "Facile fabrication of highly interconnected poly(lactic acid)‐based scaffolds with good hydrophilicity using supercritical carbon dioxide" @default.
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- W4368363603 doi "https://doi.org/10.1002/app.54047" @default.
- W4368363603 hasPublicationYear "2023" @default.
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