Matches in SemOpenAlex for { <https://semopenalex.org/work/W4368366903> ?p ?o ?g. }
Showing items 1 to 61 of
61
with 100 items per page.
- W4368366903 abstract "Abstract: This paper outlines the methodology and results for a two species finite volume scalar computational drug transport model developed for simulating the mass transport of Poly(lactic-co-glycolic acid (PLGA) ) from a half-embedded single strut implanted in a coronary arterial vessel wall. The mathematical drug transport model incorporates the convection-diffusion equation in scalar form (dimensionless) with a two species (free-drug and bound-drug) mass transport setup including reversible equilibrium reaction source terms for the free and bound-drug states to account for the pharmaco-kinetic reactions in the arterial wall. The relative reaction rates of the added source terms control the interconversion of drug between the free and bound-drug states. The model is solved by a 2-D finite-volume method for discretizing and solving the free and bound drug transport equations with anisotropic vascular drug diffusivities. This model is an improvement over our previously developed model using the finite-difference method. A dimensionless characteristic scaling pre-analysis was conducted a priori to evaluate the significance of implementing the reaction source terms in the transport equations. This paper reports the findings of an investigation of the interstitial flow profile into the arterial wall and the free and bound drug diffusion profiles with a parametric study of varying polymer drug concentration (low and high), tortuosity, porosity, and Peclet and DamKöhler numbers over the course of 400 hours (16.67 days). The results also reveal how a single species drug delivery model that neglects both a reversible binding reaction source term and the porosity and tortuosity of the arterial wall cannot accurately predict the distribution of both the free and bound drug." @default.
- W4368366903 created "2023-05-05" @default.
- W4368366903 creator A5007750319 @default.
- W4368366903 creator A5015508467 @default.
- W4368366903 creator A5071556002 @default.
- W4368366903 date "2023-05-03" @default.
- W4368366903 modified "2023-09-25" @default.
- W4368366903 title "A Two-Species Finite Volume Scalar Model for Modelling the Diffusion of Poly<em>(lactic-co-glycolic acid)</em> into a Coronary Arterial Wall from a Single Half-Embedded Drug Eluting Stent Strut" @default.
- W4368366903 doi "https://doi.org/10.20944/preprints202305.0090.v1" @default.
- W4368366903 hasPublicationYear "2023" @default.
- W4368366903 type Work @default.
- W4368366903 citedByCount "0" @default.
- W4368366903 crossrefType "posted-content" @default.
- W4368366903 hasAuthorship W4368366903A5007750319 @default.
- W4368366903 hasAuthorship W4368366903A5015508467 @default.
- W4368366903 hasAuthorship W4368366903A5071556002 @default.
- W4368366903 hasBestOaLocation W43683669031 @default.
- W4368366903 hasConcept C121332964 @default.
- W4368366903 hasConcept C134306372 @default.
- W4368366903 hasConcept C17456955 @default.
- W4368366903 hasConcept C185592680 @default.
- W4368366903 hasConcept C192562407 @default.
- W4368366903 hasConcept C205684552 @default.
- W4368366903 hasConcept C24872484 @default.
- W4368366903 hasConcept C2524010 @default.
- W4368366903 hasConcept C33923547 @default.
- W4368366903 hasConcept C50478463 @default.
- W4368366903 hasConcept C57691317 @default.
- W4368366903 hasConcept C69357855 @default.
- W4368366903 hasConcept C73000952 @default.
- W4368366903 hasConcept C97355855 @default.
- W4368366903 hasConceptScore W4368366903C121332964 @default.
- W4368366903 hasConceptScore W4368366903C134306372 @default.
- W4368366903 hasConceptScore W4368366903C17456955 @default.
- W4368366903 hasConceptScore W4368366903C185592680 @default.
- W4368366903 hasConceptScore W4368366903C192562407 @default.
- W4368366903 hasConceptScore W4368366903C205684552 @default.
- W4368366903 hasConceptScore W4368366903C24872484 @default.
- W4368366903 hasConceptScore W4368366903C2524010 @default.
- W4368366903 hasConceptScore W4368366903C33923547 @default.
- W4368366903 hasConceptScore W4368366903C50478463 @default.
- W4368366903 hasConceptScore W4368366903C57691317 @default.
- W4368366903 hasConceptScore W4368366903C69357855 @default.
- W4368366903 hasConceptScore W4368366903C73000952 @default.
- W4368366903 hasConceptScore W4368366903C97355855 @default.
- W4368366903 hasLocation W43683669031 @default.
- W4368366903 hasOpenAccess W4368366903 @default.
- W4368366903 hasPrimaryLocation W43683669031 @default.
- W4368366903 hasRelatedWork W1742369028 @default.
- W4368366903 hasRelatedWork W2113882650 @default.
- W4368366903 hasRelatedWork W2130241864 @default.
- W4368366903 hasRelatedWork W2523955724 @default.
- W4368366903 hasRelatedWork W2802596232 @default.
- W4368366903 hasRelatedWork W291393588 @default.
- W4368366903 hasRelatedWork W2979752376 @default.
- W4368366903 hasRelatedWork W3042605453 @default.
- W4368366903 hasRelatedWork W3134921658 @default.
- W4368366903 hasRelatedWork W3197902065 @default.
- W4368366903 isParatext "false" @default.
- W4368366903 isRetracted "false" @default.
- W4368366903 workType "article" @default.