Matches in SemOpenAlex for { <https://semopenalex.org/work/W4368367088> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W4368367088 abstract "Although the APOBEC3 family of single-stranded DNA cytosine deaminases are well-known as antiviral factors, these enzymes are rapidly gaining attention as prominent sources of mutation in cancer. APOBEC3 signature single base substitutions, C-to-T and C-to-G in TCA and TCT motifs, are evident in over 70% of human malignancies and dominate the mutational landscape of numerous individual tumors. Recent murine studies have established cause-and-effect relationships, with both human APOBEC3A and APOBEC3B proving capable of promoting tumor formation in vivo. Here, we investigate the molecular mechanism of APOBEC3A-driven tumor development using the murine Fah liver complementation and regeneration system. First, we show that APOBEC3A alone is capable of driving tumor development (without Tp53 knockdown as in prior studies). Second, we show that the catalytic glutamic acid residue of APOBEC3A (E72) is required for tumor formation. Third, we show that an APOBEC3A separation-of-function mutant with compromised DNA deamination activity and wildtype RNA editing activity is defective in promoting tumor formation. Collectively, these results indicate that APOBEC3A is a “master driver” that fuels tumor formation through a DNA deamination-dependent mechanism." @default.
- W4368367088 created "2023-05-05" @default.
- W4368367088 creator A5005626540 @default.
- W4368367088 creator A5005976562 @default.
- W4368367088 creator A5012612977 @default.
- W4368367088 creator A5017130108 @default.
- W4368367088 creator A5018465635 @default.
- W4368367088 creator A5022713049 @default.
- W4368367088 creator A5035901749 @default.
- W4368367088 creator A5036162164 @default.
- W4368367088 creator A5041880481 @default.
- W4368367088 creator A5056554657 @default.
- W4368367088 creator A5057569595 @default.
- W4368367088 creator A5062105407 @default.
- W4368367088 creator A5064782323 @default.
- W4368367088 creator A5081186975 @default.
- W4368367088 creator A5089263486 @default.
- W4368367088 creator A5091071144 @default.
- W4368367088 date "2023-05-02" @default.
- W4368367088 modified "2023-09-27" @default.
- W4368367088 title "DNA Deamination Is Required for Human APOBEC3A-Driven Hepatocellular Carcinoma In Vivo" @default.
- W4368367088 doi "https://doi.org/10.20944/preprints202305.0072.v1" @default.
- W4368367088 hasPublicationYear "2023" @default.
- W4368367088 type Work @default.
- W4368367088 citedByCount "0" @default.
- W4368367088 crossrefType "posted-content" @default.
- W4368367088 hasAuthorship W4368367088A5005626540 @default.
- W4368367088 hasAuthorship W4368367088A5005976562 @default.
- W4368367088 hasAuthorship W4368367088A5012612977 @default.
- W4368367088 hasAuthorship W4368367088A5017130108 @default.
- W4368367088 hasAuthorship W4368367088A5018465635 @default.
- W4368367088 hasAuthorship W4368367088A5022713049 @default.
- W4368367088 hasAuthorship W4368367088A5035901749 @default.
- W4368367088 hasAuthorship W4368367088A5036162164 @default.
- W4368367088 hasAuthorship W4368367088A5041880481 @default.
- W4368367088 hasAuthorship W4368367088A5056554657 @default.
- W4368367088 hasAuthorship W4368367088A5057569595 @default.
- W4368367088 hasAuthorship W4368367088A5062105407 @default.
- W4368367088 hasAuthorship W4368367088A5064782323 @default.
- W4368367088 hasAuthorship W4368367088A5081186975 @default.
- W4368367088 hasAuthorship W4368367088A5089263486 @default.
- W4368367088 hasAuthorship W4368367088A5091071144 @default.
- W4368367088 hasBestOaLocation W43683670881 @default.
- W4368367088 hasConcept C104317684 @default.
- W4368367088 hasConcept C111599444 @default.
- W4368367088 hasConcept C145782189 @default.
- W4368367088 hasConcept C153911025 @default.
- W4368367088 hasConcept C181199279 @default.
- W4368367088 hasConcept C185592680 @default.
- W4368367088 hasConcept C207001950 @default.
- W4368367088 hasConcept C2776023528 @default.
- W4368367088 hasConcept C2777748644 @default.
- W4368367088 hasConcept C502942594 @default.
- W4368367088 hasConcept C54355233 @default.
- W4368367088 hasConcept C552990157 @default.
- W4368367088 hasConcept C55493867 @default.
- W4368367088 hasConcept C86803240 @default.
- W4368367088 hasConceptScore W4368367088C104317684 @default.
- W4368367088 hasConceptScore W4368367088C111599444 @default.
- W4368367088 hasConceptScore W4368367088C145782189 @default.
- W4368367088 hasConceptScore W4368367088C153911025 @default.
- W4368367088 hasConceptScore W4368367088C181199279 @default.
- W4368367088 hasConceptScore W4368367088C185592680 @default.
- W4368367088 hasConceptScore W4368367088C207001950 @default.
- W4368367088 hasConceptScore W4368367088C2776023528 @default.
- W4368367088 hasConceptScore W4368367088C2777748644 @default.
- W4368367088 hasConceptScore W4368367088C502942594 @default.
- W4368367088 hasConceptScore W4368367088C54355233 @default.
- W4368367088 hasConceptScore W4368367088C552990157 @default.
- W4368367088 hasConceptScore W4368367088C55493867 @default.
- W4368367088 hasConceptScore W4368367088C86803240 @default.
- W4368367088 hasLocation W43683670881 @default.
- W4368367088 hasOpenAccess W4368367088 @default.
- W4368367088 hasPrimaryLocation W43683670881 @default.
- W4368367088 hasRelatedWork W1979923522 @default.
- W4368367088 hasRelatedWork W1993168212 @default.
- W4368367088 hasRelatedWork W2017924370 @default.
- W4368367088 hasRelatedWork W2059881824 @default.
- W4368367088 hasRelatedWork W2072767862 @default.
- W4368367088 hasRelatedWork W2091106301 @default.
- W4368367088 hasRelatedWork W2094225047 @default.
- W4368367088 hasRelatedWork W2109410065 @default.
- W4368367088 hasRelatedWork W2402112962 @default.
- W4368367088 hasRelatedWork W2802943978 @default.
- W4368367088 isParatext "false" @default.
- W4368367088 isRetracted "false" @default.
- W4368367088 workType "article" @default.