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- W4368367144 abstract "Cancers of the gastrointestinal tract (GIT) are the most common human malignancies. The prevalence of esophageal Cancer, pancreatic ductal adenocarcinoma, gastric Cancer, hepatocellular carcinoma, colorectal Cancer and gallbladder Cancer are on the rise now a days. Despite advances in cancer treatment, increasing reports are focusing on finding novel therapies with lower side effects and higher potency. From the mechanistic point of view, several dysregulated factors are behind the pathophysiology of GIT cancers. Multiple studies have shown molecular targeted therapies in various GIT cancers, including epidermal growth factor receptor pathway (EGFR), vascular endothelial growth factor pathway (VEGF), Wnt/β-catenin pathway, and insulin-like growth factor receptor (IGFR).The aforementioned mediators are the critical targets of the existence of monoclonal antibodies and small molecules in treating GIT cancers. Accordingly, providing the exact dysregulated mechanisms behind GIT cancers could pave the road in the treatment of cancers. This chapter reveals dysregulated signaling pathways and potential therapeutic agents in the treatment of GIT cancer.<br>" @default.
- W4368367144 created "2023-05-05" @default.
- W4368367144 creator A5003186251 @default.
- W4368367144 creator A5019861230 @default.
- W4368367144 creator A5072352101 @default.
- W4368367144 creator A5085120624 @default.
- W4368367144 date "2023-04-27" @default.
- W4368367144 modified "2023-09-26" @default.
- W4368367144 title "Pathophysiology of Gastrointestinal Tract Cancers and Therapeutic Status" @default.
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