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• W4368617550 endingPage "e1011372" @default.
• W4368617550 startingPage "e1011372" @default.
• W4368617550 abstract "Giardia intestinalis is a non-invasive, protozoan parasite infecting the upper small intestine of most mammals. Symptomatic infections cause the diarrhoeal disease giardiasis in humans and animals, but at least half of the infections are asymptomatic. However, the molecular underpinnings of these different outcomes of the infection are still poorly defined. Here, we studied the early transcriptional response to G . intestinalis trophozoites , the disease-causing life-cycle stage, in human enteroid-derived, 2-dimensional intestinal epithelial cell (IEC) monolayers. Trophozoites preconditioned in media that maximise parasite fitness triggered only neglectable inflammatory transcription in the IECs during the first hours of co-incubation. By sharp contrast, “non-fit” or lysed trophozoites induced a vigorous IEC transcriptional response, including high up-regulation of many inflammatory cytokines and chemokines. Furthermore, “fit” trophozoites could even suppress the stimulatory effect of lysed trophozoites in mixed infections, suggesting active G . intestinalis suppression of the IEC response. By dual-species RNA-sequencing, we defined the IEC and G . intestinalis gene expression programs associated with these differential outcomes of the infection. Taken together, our results inform on how G . intestinalis infection can lead to such highly variable effects on the host, and pinpoints trophozoite fitness as a key determinant of the IEC response to this common parasite." @default.
• W4368617550 created "2023-05-05" @default.
• W4368617550 creator A5016727456 @default.
• W4368617550 creator A5052828787 @default.
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• W4368617550 creator A5068473291 @default.
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• W4368617550 creator A5073736264 @default.
• W4368617550 creator A5077696792 @default.
• W4368617550 creator A5091550252 @default.
• W4368617550 date "2023-05-04" @default.
• W4368617550 modified "2023-10-13" @default.
• W4368617550 title "Trophozoite fitness dictates the intestinal epithelial cell response to Giardia intestinalis infection" @default.
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