FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4368618054> ?p ?o ?g. }

• W4368618054 endingPage "e875" @default.
• W4368618054 startingPage "e875" @default.
• W4368618054 abstract "IKZF1 deletions are an established prognostic factor in childhood acute lymphoblastic leukemia (ALL). However, their relevance in patients with good risk genetics, namely ETV6::RUNX1 and high hyperdiploid (HeH), ALL remains unclear. We assessed the prognostic impact of IKZF1 deletions in 939 ETV6::RUNX1 and 968 HeH ALL patients by evaluating data from 16 trials from 9 study groups. Only 3% of ETV6::RUNX1 cases (n = 26) were IKZF1-deleted; this adversely affected survival combining all trials (5-year event-free survival [EFS], 79% versus 92%; P = 0.02). No relapses occurred among the 14 patients with an IKZF1 deletion treated on a minimal residual disease (MRD)-guided protocols. Nine percent of HeH cases (n = 85) had an IKZF1 deletion; this adversely affected survival in all trials (5-year EFS, 76% versus 89%; P = 0.006) and in MRD-guided protocols (73% versus 88%; P = 0.004). HeH cases with an IKZF1 deletion had significantly higher end of induction MRD values (P = 0.03). Multivariate Cox regression showed that IKZF1 deletions negatively affected survival independent of sex, age, and white blood cell count at diagnosis in HeH ALL (hazard ratio of relapse rate [95% confidence interval]: 2.48 [1.32-4.66]). There was no evidence to suggest that IKZF1 deletions affected outcome in the small number of ETV6::RUNX1 cases in MRD-guided protocols but that they are related to higher MRD values, higher relapse, and lower survival rates in HeH ALL. Future trials are needed to study whether stratifying by MRD is adequate for HeH patients or additional risk stratification is necessary. Export" @default.
• W4368618054 created "2023-05-05" @default.
• W4368618054 creator A5016091450 @default.
• W4368618054 creator A5022986622 @default.
• W4368618054 creator A5024275910 @default.
• W4368618054 creator A5032713965 @default.
• W4368618054 creator A5032784001 @default.
• W4368618054 creator A5035292815 @default.
• W4368618054 creator A5038325579 @default.
• W4368618054 creator A5059308615 @default.
• W4368618054 creator A5066319509 @default.
• W4368618054 creator A5070407753 @default.
• W4368618054 creator A5072783110 @default.
• W4368618054 creator A5074845542 @default.
• W4368618054 creator A5080177259 @default.
• W4368618054 creator A5082829887 @default.
• W4368618054 creator A5088705008 @default.
• W4368618054 date "2023-05-01" @default.
• W4368618054 modified "2023-09-30" @default.
• W4368618054 title "The Prognostic Effect of IKZF1 Deletions in ETV6::RUNX1 and High Hyperdiploid Childhood Acute Lymphoblastic Leukemia" @default.
• W4368618054 cites W1569839307 @default.
• W4368618054 cites W1573078268 @default.
• W4368618054 cites W1919084303 @default.
• W4368618054 cites W1998576290 @default.
• W4368618054 cites W2015869717 @default.
• W4368618054 cites W2024888688 @default.
• W4368618054 cites W2033383345 @default.
• W4368618054 cites W2051218108 @default.
• W4368618054 cites W2052505636 @default.
• W4368618054 cites W2071818770 @default.
• W4368618054 cites W2089583676 @default.
• W4368618054 cites W2089624490 @default.
• W4368618054 cites W2096709475 @default.
• W4368618054 cites W2096875118 @default.
• W4368618054 cites W2105345844 @default.
• W4368618054 cites W2125277492 @default.
• W4368618054 cites W2126930838 @default.
• W4368618054 cites W2139969490 @default.
• W4368618054 cites W2153818728 @default.
• W4368618054 cites W2154410907 @default.
• W4368618054 cites W2163001955 @default.
• W4368618054 cites W2163926478 @default.
• W4368618054 cites W2166089525 @default.
• W4368618054 cites W2278470648 @default.
• W4368618054 cites W2311406774 @default.
• W4368618054 cites W2413038045 @default.
• W4368618054 cites W2516575316 @default.
• W4368618054 cites W2745522463 @default.
• W4368618054 cites W2769895972 @default.
• W4368618054 cites W2775805345 @default.
• W4368618054 cites W2784353927 @default.
• W4368618054 cites W2794056739 @default.
• W4368618054 cites W2811286257 @default.
• W4368618054 cites W2910434299 @default.
• W4368618054 cites W2922500791 @default.
• W4368618054 cites W2958420196 @default.
• W4368618054 cites W3005762182 @default.
• W4368618054 cites W3100280814 @default.
• W4368618054 cites W3154748098 @default.
• W4368618054 cites W3206913772 @default.
• W4368618054 cites W3210124852 @default.
• W4368618054 doi "https://doi.org/10.1097/hs9.0000000000000875" @default.
• W4368618054 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37153875" @default.
• W4368618054 hasPublicationYear "2023" @default.
• W4368618054 type Work @default.
• W4368618054 citedByCount "0" @default.
• W4368618054 crossrefType "journal-article" @default.
• W4368618054 hasAuthorship W4368618054A5016091450 @default.
• W4368618054 hasAuthorship W4368618054A5022986622 @default.
• W4368618054 hasAuthorship W4368618054A5024275910 @default.
• W4368618054 hasAuthorship W4368618054A5032713965 @default.
• W4368618054 hasAuthorship W4368618054A5032784001 @default.
• W4368618054 hasAuthorship W4368618054A5035292815 @default.
• W4368618054 hasAuthorship W4368618054A5038325579 @default.
• W4368618054 hasAuthorship W4368618054A5059308615 @default.
• W4368618054 hasAuthorship W4368618054A5066319509 @default.
• W4368618054 hasAuthorship W4368618054A5070407753 @default.
• W4368618054 hasAuthorship W4368618054A5072783110 @default.
• W4368618054 hasAuthorship W4368618054A5074845542 @default.
• W4368618054 hasAuthorship W4368618054A5080177259 @default.
• W4368618054 hasAuthorship W4368618054A5082829887 @default.
• W4368618054 hasAuthorship W4368618054A5088705008 @default.
• W4368618054 hasBestOaLocation W43686180541 @default.
• W4368618054 hasConcept C104317684 @default.
• W4368618054 hasConcept C126322002 @default.
• W4368618054 hasConcept C138626823 @default.
• W4368618054 hasConcept C143998085 @default.
• W4368618054 hasConcept C203014093 @default.
• W4368618054 hasConcept C207103383 @default.
• W4368618054 hasConcept C2778461978 @default.
• W4368618054 hasConcept C2779823535 @default.
• W4368618054 hasConcept C2780833115 @default.
• W4368618054 hasConcept C44249647 @default.
• W4368618054 hasConcept C50382708 @default.
• W4368618054 hasConcept C54355233 @default.
• W4368618054 hasConcept C71924100 @default.
• W4368618054 hasConcept C86803240 @default.
• W4368618054 hasConceptScore W4368618054C104317684 @default.

• next