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• W43708320 abstract "Research Article1 September 1993free access Structure and activity of regulatory elements involved in the activation of the Hoxd-11 gene during late gastrulation. M. Gérard M. Gérard European Molecular Biology Laboratory, Heidelberg, Germany. Search for more papers by this author D. Duboule D. Duboule European Molecular Biology Laboratory, Heidelberg, Germany. Search for more papers by this author J. Zákány J. Zákány European Molecular Biology Laboratory, Heidelberg, Germany. Search for more papers by this author M. Gérard M. Gérard European Molecular Biology Laboratory, Heidelberg, Germany. Search for more papers by this author D. Duboule D. Duboule European Molecular Biology Laboratory, Heidelberg, Germany. Search for more papers by this author J. Zákány J. Zákány European Molecular Biology Laboratory, Heidelberg, Germany. Search for more papers by this author Author Information M. Gérard1, D. Duboule1 and J. Zákány1 1European Molecular Biology Laboratory, Heidelberg, Germany. The EMBO Journal (1993)12:3539-3550https://doi.org/10.1002/j.1460-2075.1993.tb06028.x PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info We have used reporter gene constructs to study the cis regulation of the Hoxd-11 gene (previously Hox-4.6) in transgenic mice. We identified a 5 kb regulatory unit, which was able to reproduce important aspects of the initial activation of the gene along the major body axis. The comparison of the nucleotide sequence of this DNA fragment with the corresponding avian genomic region revealed the presence of seven highly homologous stretches of DNA outside the protein coding regions. In particular, the 3′ flanking region contained two such domains that are required to mediate the embryonic activation. A chimeric construct containing the two short homologous regions from the chicken gene could replace the complete murine fragment thus demonstrating that the conserved domains carry the main regulatory elements involved in this activation. The first half of this bipartite regulatory region has enhancer activity when tested with a heterologous promoter, while the second half is required to restrict the enhancer activity to the proper expression domain. These results suggest that stage- and tissue-specific cooperation between regulatory elements is required to control properly the activity of the Hoxd-11 promoter. Previous ArticleNext Article Volume 12Issue 91 September 1993In this issue RelatedDetailsLoading ..." @default.
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• W43708320 title "Structure and activity of regulatory elements involved in the activation of the Hoxd-11 gene during late gastrulation." @default.
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• W43708320 doi "https://doi.org/10.1002/j.1460-2075.1993.tb06028.x" @default.
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