Matches in SemOpenAlex for { <https://semopenalex.org/work/W4371783432> ?p ?o ?g. }
- W4371783432 abstract "Significant advancements have been made in the treatment of advanced melanoma with the use of immune checkpoint inhibitors, novel immunotherapies, and BRAF/MEK-targeted therapies with numerous frontline treatment options. However, there remains suboptimal evidence to guide treatment decisions in many patients. These include patients with newly diagnosed disease, immune checkpoint inhibitor (ICI)-resistant/ICI-refractory disease, CNS metastases, history of autoimmune disease, and/or immune-related adverse events (irAEs). Uveal melanoma (UM) is a rare melanoma associated with a poor prognosis in the metastatic setting. Systemic treatments, including checkpoint inhibitors, failed to demonstrate any survival benefit. Tebentafusp, a bispecific molecule, is the first treatment to improve overall survival (OS) in patients with HLA A*02:01-positive metastatic UM." @default.
- W4371783432 created "2023-05-07" @default.
- W4371783432 creator A5003536346 @default.
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- W4371783432 creator A5066489948 @default.
- W4371783432 creator A5084951473 @default.
- W4371783432 creator A5090315590 @default.
- W4371783432 date "2023-01-01" @default.
- W4371783432 modified "2023-09-29" @default.
- W4371783432 title "Evolving Management of Stage IV Melanoma" @default.
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- W4371783432 doi "https://doi.org/10.1200/edbk_397478" @default.
- W4371783432 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37141553" @default.
- W4371783432 hasPublicationYear "2023" @default.
- W4371783432 type Work @default.