Matches in SemOpenAlex for { <https://semopenalex.org/work/W4372204180> ?p ?o ?g. }
- W4372204180 endingPage "110236" @default.
- W4372204180 startingPage "110236" @default.
- W4372204180 abstract "Colorectal cancer (CRC) is currently recognized as the third most prevalent cancer worldwide. Vinpocetine is a synthetic derivative of the vinca alkaloid vincamine. It has been found effective in ameliorating the growth and progression of cancerous cells. However, its pharmacological effect on colon damage remains elusive. Hence, in this study, we have shown the role of vinpocetine in DMH-induced colon carcinogenesis. At first, male albino Wistar rats were administered with DMH consistently for four weeks to induce pre-neoplastic colon damage. Afterward, animals were treated with vinpocetine (4.2 and 8.4 mg/kg/day p.o.) for 15 days. Serum samples were collected to assess the physiological parameters, including ELISA and NMR metabolomics. Colon from all the groups was collected and processed separately for histopathology and western blot analysis. Vinpocetine attenuated the altered plasma parameters; lipid profile and showed anti-proliferative action as evidenced by suppressed COX-2 stimulation and decreased levels of IL-1β, IL-2, IL-6, and IL-10. Vinpocetine is significantly effective in preventing CRC which may be associated with its anti-inflammatory and antioxidant potential. Accordingly, vinpocetine could serve as a potential anticancer agent for CRC treatment and thus be considered for future clinical and therapeutic research." @default.
- W4372204180 created "2023-05-07" @default.
- W4372204180 creator A5003648125 @default.
- W4372204180 creator A5005865936 @default.
- W4372204180 creator A5010840445 @default.
- W4372204180 creator A5012613217 @default.
- W4372204180 creator A5016105867 @default.
- W4372204180 creator A5024160787 @default.
- W4372204180 creator A5025227667 @default.
- W4372204180 creator A5032792810 @default.
- W4372204180 creator A5036256284 @default.
- W4372204180 creator A5044140072 @default.
- W4372204180 creator A5048364915 @default.
- W4372204180 creator A5061862397 @default.
- W4372204180 creator A5087095008 @default.
- W4372204180 date "2023-06-01" @default.
- W4372204180 modified "2023-10-06" @default.
- W4372204180 title "Vinpocetine mitigates DMH-induce pre-neoplastic colon damage in rats through inhibition of pro-inflammatory cytokines" @default.
- W4372204180 cites W1971372975 @default.
- W4372204180 cites W1972908310 @default.
- W4372204180 cites W1973166702 @default.
- W4372204180 cites W1976327004 @default.
- W4372204180 cites W1987686562 @default.
- W4372204180 cites W2002558342 @default.
- W4372204180 cites W2014366212 @default.
- W4372204180 cites W2023752098 @default.
- W4372204180 cites W2031777771 @default.
- W4372204180 cites W2033226391 @default.
- W4372204180 cites W2058253589 @default.
- W4372204180 cites W2066411725 @default.
- W4372204180 cites W2068382972 @default.
- W4372204180 cites W2075350256 @default.
- W4372204180 cites W2075950474 @default.
- W4372204180 cites W2088386397 @default.
- W4372204180 cites W2102154168 @default.
- W4372204180 cites W2109444127 @default.
- W4372204180 cites W2136236996 @default.
- W4372204180 cites W2147504123 @default.
- W4372204180 cites W2155816936 @default.
- W4372204180 cites W2156358891 @default.
- W4372204180 cites W2165681080 @default.
- W4372204180 cites W2255950471 @default.
- W4372204180 cites W2302003756 @default.
- W4372204180 cites W2340523810 @default.
- W4372204180 cites W2480914729 @default.
- W4372204180 cites W2588391650 @default.
- W4372204180 cites W2601821901 @default.
- W4372204180 cites W2612408034 @default.
- W4372204180 cites W2626439516 @default.
- W4372204180 cites W2761894563 @default.
- W4372204180 cites W2766726453 @default.
- W4372204180 cites W2790448555 @default.
- W4372204180 cites W2791033549 @default.
- W4372204180 cites W2791060512 @default.
- W4372204180 cites W2807134999 @default.
- W4372204180 cites W2914790376 @default.
- W4372204180 cites W2944871112 @default.
- W4372204180 cites W2974538492 @default.
- W4372204180 cites W2986572941 @default.
- W4372204180 cites W3021404331 @default.
- W4372204180 cites W3108575121 @default.
- W4372204180 cites W3144160449 @default.
- W4372204180 doi "https://doi.org/10.1016/j.intimp.2023.110236" @default.
- W4372204180 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37148772" @default.
- W4372204180 hasPublicationYear "2023" @default.
- W4372204180 type Work @default.
- W4372204180 citedByCount "2" @default.
- W4372204180 countsByYear W43722041802023 @default.
- W4372204180 crossrefType "journal-article" @default.
- W4372204180 hasAuthorship W4372204180A5003648125 @default.
- W4372204180 hasAuthorship W4372204180A5005865936 @default.
- W4372204180 hasAuthorship W4372204180A5010840445 @default.
- W4372204180 hasAuthorship W4372204180A5012613217 @default.
- W4372204180 hasAuthorship W4372204180A5016105867 @default.
- W4372204180 hasAuthorship W4372204180A5024160787 @default.
- W4372204180 hasAuthorship W4372204180A5025227667 @default.
- W4372204180 hasAuthorship W4372204180A5032792810 @default.
- W4372204180 hasAuthorship W4372204180A5036256284 @default.
- W4372204180 hasAuthorship W4372204180A5044140072 @default.
- W4372204180 hasAuthorship W4372204180A5048364915 @default.
- W4372204180 hasAuthorship W4372204180A5061862397 @default.
- W4372204180 hasAuthorship W4372204180A5087095008 @default.
- W4372204180 hasConcept C104317684 @default.
- W4372204180 hasConcept C121608353 @default.
- W4372204180 hasConcept C126322002 @default.
- W4372204180 hasConcept C185592680 @default.
- W4372204180 hasConcept C2776415932 @default.
- W4372204180 hasConcept C2778788455 @default.
- W4372204180 hasConcept C526805850 @default.
- W4372204180 hasConcept C55493867 @default.
- W4372204180 hasConcept C71924100 @default.
- W4372204180 hasConcept C98274493 @default.
- W4372204180 hasConceptScore W4372204180C104317684 @default.
- W4372204180 hasConceptScore W4372204180C121608353 @default.
- W4372204180 hasConceptScore W4372204180C126322002 @default.
- W4372204180 hasConceptScore W4372204180C185592680 @default.
- W4372204180 hasConceptScore W4372204180C2776415932 @default.
- W4372204180 hasConceptScore W4372204180C2778788455 @default.