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• W4372219005 endingPage "602" @default.
• W4372219005 startingPage "595" @default.
• W4372219005 abstract "Recurrent aphthous stomatitis (RAS) is a painful disorder that commonly appears as ulcers on the oral mucosa, lasting ∼two weeks (minor) to months (major and herpetiform). Current treatment often necessitates the use of topical steroids in the form of pastes, mouthwashes, or gels, but these forms are often ineffective due to inadequate drug contact time with the ulcers. In this study, the performance of novel bilayer mucoadhesive buccal films loaded with triamcinolone acetonide (TA) has been evaluated for targeted drug delivery. Experimental mucoadhesive films of hydroxypropyl methylcellulose (HPMC), polyvinyl alcohol (PVA), and polyvinyl pyrrolidone (PVP) were prepared by the solvent casting method, and ethyl cellulose (EC) was applied as the backing layer. The films were characterized for their physical properties, including swelling index (SI), folding endurance, adhesion force with porcine buccal mucosa, residence time and in-vitro drug release. The data showed that the films were flexible with folding endurance> 300 times. With porcine buccal mucosa i) suitable adhesion forces were obtained (between 2.72 and 4.03 N), ii) residence times of> 24 h, and iii) surface pH between 6.8 and 7.1 indicating they would be non-irritant. All films released 100% TA over 6 h, but with varying profiles. The release of TA (over 6 h) from PVP-free films followed Fickian diffusion kinetics (diffusion-controlled release of drug), whereas the mechanism of release from PVP-containing films was found to be a superposition of diffusion-controlled and erosion-controlled release (anomalous). The developed films hold great promise for potentially treating RAS and other oral conditions." @default.
• W4372219005 created "2023-05-07" @default.
• W4372219005 creator A5031342699 @default.
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• W4372219005 date "2023-06-01" @default.
• W4372219005 modified "2023-10-18" @default.
• W4372219005 title "Triamcinolone acetonide release modelling from novel bilayer mucoadhesive films: an in vitro study" @default.
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• W4372219005 doi "https://doi.org/10.1016/j.dental.2023.04.005" @default.
• W4372219005 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37150730" @default.
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