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- W4372227954 endingPage "665" @default.
- W4372227954 startingPage "650" @default.
- W4372227954 abstract "Many patients with metastatic or treatment-resistant cancer have experienced improved outcomes after immunotherapy that targets adaptive immune checkpoints. However, innate immune checkpoints, which can hinder the detection and clearance of malignant cells, are also crucial in tumor-mediated immune escape and may also serve as targets in cancer immunotherapy. In this review, we discuss the current understanding of immune evasion by cancer cells via disruption of phagocytic clearance, and the potential effects of blocking phagocytosis checkpoints on the activation of antitumor immune responses. We propose that a more effective combination immunotherapy strategy could be to exploit tumor-intrinsic processes that inhibit key innate immune surveillance processes, such as phagocytosis, and incorporate both innate and adaptive immune responses for treating patients with cancer." @default.
- W4372227954 created "2023-05-07" @default.
- W4372227954 creator A5017997501 @default.
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- W4372227954 creator A5070712895 @default.
- W4372227954 creator A5078626693 @default.
- W4372227954 creator A5087286844 @default.
- W4372227954 creator A5090210760 @default.
- W4372227954 date "2023-08-01" @default.
- W4372227954 modified "2023-10-17" @default.
- W4372227954 title "Targeting phagocytosis to enhance antitumor immunity" @default.
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