Matches in SemOpenAlex for { <https://semopenalex.org/work/W4372284098> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W4372284098 endingPage "98" @default.
- W4372284098 startingPage "91" @default.
- W4372284098 abstract "MicroRNA (miR)-185-5p participates in the pathology of asthma by regulating immune imbalance, inflammation, periostin synthesis, and smooth muscle contraction. This study intended to explore the dysregulation of miR-185p and its correlation with T-helper (Th)1, Th2 cells, and inflammatory cytokines in childhood asthma.In 150 childhood asthma patients and 30 healthy controls (HCs), miR-185-5p from peripheral blood mononuclear cells was detected using reverse transcription-quantitative polymerase chain reaction, Th cells from peripheral blood samples were detected using flow cytometry, inflammatory cytokines from serum samples were detected using enzyme-linked immunosorbent assay.MiR-185-5p was increased in childhood asthma patients versus HCs [median (interquartile range (IQR)): 2.315 (1.770-3.855) versus 1.005 (0.655-1.520)] (P < 0.001). Meanwhile, miR-185-5p was negatively associated with Th1 cells (P = 0.035) but positively correlated with Th2 cells (P = 0.006) and IL-4 (P = 0.003) in childhood asthma patients; however, miR-185-5p was not linked to Th1 cells, Th2 cells, IFN-γ, or IL-4 in HCs (all P > 0.05). In addition, miR-185-5p was positively related to TNF-α (P < 0.001), IL-1β (P = 0.015), and IL-6 (P = 0.008) in childhood asthma patients, miR-185-5p was only linked to TNF-α (P = 0.040) but not IL-1β or IL-6 (both P > 0.05) in HCs. Moreover, miR-185-5p was increased in exacerbated childhood asthma patients versus remissive patients [median (IQR): 3.170 (2.070-4.905) versus 1.900 (1.525-2.615)] (P < 0.001). Besides, miR-185-5p was highest in patients with severe exacerbation followed by patients with moderate exacerbation, and lowest in patients with mild exacerbation (P = 0.010).MiR-185-5p is associated with imbalanced Th1/Th2 cells, increased inflammatory cytokines along with elevated exacerbation risk, and severity in childhood asthma patients." @default.
- W4372284098 created "2023-05-07" @default.
- W4372284098 creator A5006449095 @default.
- W4372284098 creator A5008168090 @default.
- W4372284098 creator A5014360868 @default.
- W4372284098 creator A5025668076 @default.
- W4372284098 creator A5026340829 @default.
- W4372284098 creator A5026776640 @default.
- W4372284098 creator A5028772518 @default.
- W4372284098 creator A5038369085 @default.
- W4372284098 creator A5058891185 @default.
- W4372284098 creator A5060002931 @default.
- W4372284098 creator A5064536511 @default.
- W4372284098 creator A5067453012 @default.
- W4372284098 creator A5078283071 @default.
- W4372284098 creator A5091798976 @default.
- W4372284098 date "2023-05-01" @default.
- W4372284098 modified "2023-10-16" @default.
- W4372284098 title "MiR-185-5p measurement assists in reflecting Th1/Th2 cell imbalance, inflammatory cytokine production, and exacerbation risk for childhood asthma" @default.
- W4372284098 doi "https://doi.org/10.15586/aei.v51i3.810" @default.
- W4372284098 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37169565" @default.
- W4372284098 hasPublicationYear "2023" @default.
- W4372284098 type Work @default.
- W4372284098 citedByCount "0" @default.
- W4372284098 crossrefType "journal-article" @default.
- W4372284098 hasAuthorship W4372284098A5006449095 @default.
- W4372284098 hasAuthorship W4372284098A5008168090 @default.
- W4372284098 hasAuthorship W4372284098A5014360868 @default.
- W4372284098 hasAuthorship W4372284098A5025668076 @default.
- W4372284098 hasAuthorship W4372284098A5026340829 @default.
- W4372284098 hasAuthorship W4372284098A5026776640 @default.
- W4372284098 hasAuthorship W4372284098A5028772518 @default.
- W4372284098 hasAuthorship W4372284098A5038369085 @default.
- W4372284098 hasAuthorship W4372284098A5058891185 @default.
- W4372284098 hasAuthorship W4372284098A5060002931 @default.
- W4372284098 hasAuthorship W4372284098A5064536511 @default.
- W4372284098 hasAuthorship W4372284098A5067453012 @default.
- W4372284098 hasAuthorship W4372284098A5078283071 @default.
- W4372284098 hasAuthorship W4372284098A5091798976 @default.
- W4372284098 hasBestOaLocation W43722840981 @default.
- W4372284098 hasConcept C119060515 @default.
- W4372284098 hasConcept C126322002 @default.
- W4372284098 hasConcept C137061746 @default.
- W4372284098 hasConcept C185592680 @default.
- W4372284098 hasConcept C189165786 @default.
- W4372284098 hasConcept C202751555 @default.
- W4372284098 hasConcept C203014093 @default.
- W4372284098 hasConcept C2776042228 @default.
- W4372284098 hasConcept C2776914184 @default.
- W4372284098 hasConcept C2777014857 @default.
- W4372284098 hasConcept C2777699602 @default.
- W4372284098 hasConcept C2778690821 @default.
- W4372284098 hasConcept C553184892 @default.
- W4372284098 hasConcept C55493867 @default.
- W4372284098 hasConcept C71924100 @default.
- W4372284098 hasConcept C86803240 @default.
- W4372284098 hasConcept C8891405 @default.
- W4372284098 hasConcept C95444343 @default.
- W4372284098 hasConceptScore W4372284098C119060515 @default.
- W4372284098 hasConceptScore W4372284098C126322002 @default.
- W4372284098 hasConceptScore W4372284098C137061746 @default.
- W4372284098 hasConceptScore W4372284098C185592680 @default.
- W4372284098 hasConceptScore W4372284098C189165786 @default.
- W4372284098 hasConceptScore W4372284098C202751555 @default.
- W4372284098 hasConceptScore W4372284098C203014093 @default.
- W4372284098 hasConceptScore W4372284098C2776042228 @default.
- W4372284098 hasConceptScore W4372284098C2776914184 @default.
- W4372284098 hasConceptScore W4372284098C2777014857 @default.
- W4372284098 hasConceptScore W4372284098C2777699602 @default.
- W4372284098 hasConceptScore W4372284098C2778690821 @default.
- W4372284098 hasConceptScore W4372284098C553184892 @default.
- W4372284098 hasConceptScore W4372284098C55493867 @default.
- W4372284098 hasConceptScore W4372284098C71924100 @default.
- W4372284098 hasConceptScore W4372284098C86803240 @default.
- W4372284098 hasConceptScore W4372284098C8891405 @default.
- W4372284098 hasConceptScore W4372284098C95444343 @default.
- W4372284098 hasIssue "3" @default.
- W4372284098 hasLocation W43722840981 @default.
- W4372284098 hasLocation W43722840982 @default.
- W4372284098 hasOpenAccess W4372284098 @default.
- W4372284098 hasPrimaryLocation W43722840981 @default.
- W4372284098 hasRelatedWork W2047209980 @default.
- W4372284098 hasRelatedWork W2087976276 @default.
- W4372284098 hasRelatedWork W2094027618 @default.
- W4372284098 hasRelatedWork W2113148377 @default.
- W4372284098 hasRelatedWork W2152173258 @default.
- W4372284098 hasRelatedWork W2162735052 @default.
- W4372284098 hasRelatedWork W2778574415 @default.
- W4372284098 hasRelatedWork W9581748 @default.
- W4372284098 hasRelatedWork W2185732136 @default.
- W4372284098 hasRelatedWork W2396811992 @default.
- W4372284098 hasVolume "51" @default.
- W4372284098 isParatext "false" @default.
- W4372284098 isRetracted "false" @default.
- W4372284098 workType "article" @default.