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- W4372284229 endingPage "1365" @default.
- W4372284229 startingPage "1365" @default.
- W4372284229 abstract "Pediatric neurological tumors are a heterogeneous group of cancers, many of which carry a poor prognosis and lack a standard of care therapy. While they have similar anatomic locations, pediatric neurological tumors harbor specific molecular signatures that distinguish them from adult brain and other neurological cancers. Recent advances through the application of genetics and imaging tools have reshaped the molecular classification and treatment of pediatric neurological tumors, specifically considering the molecular alterations involved. A multidisciplinary effort is ongoing to develop new therapeutic strategies for these tumors, employing innovative and established approaches. Strikingly, there is increasing evidence that lipid metabolism is altered during the development of these types of tumors. Thus, in addition to targeted therapies focusing on classical oncogenes, new treatments are being developed based on a broad spectrum of strategies, ranging from vaccines to viral vectors, and melitherapy. This work reviews the current therapeutic landscape for pediatric brain tumors, considering new emerging treatments and ongoing clinical trials. In addition, the role of lipid metabolism in these neoplasms and its relevance for the development of novel therapies are discussed." @default.
- W4372284229 created "2023-05-07" @default.
- W4372284229 creator A5019545057 @default.
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- W4372284229 creator A5074762521 @default.
- W4372284229 creator A5086146085 @default.
- W4372284229 date "2023-05-05" @default.
- W4372284229 modified "2023-10-14" @default.
- W4372284229 title "Evolving Diagnostic and Treatment Strategies for Pediatric CNS Tumors: The Impact of Lipid Metabolism" @default.
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