FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4372318346> ?p ?o ?g. }

• W4372318346 endingPage "4730" @default.
• W4372318346 startingPage "4716" @default.
• W4372318346 abstract "Alzheimer’s disease (AD) is the most common neurological ailment worldwide. Its process comprises the unique aggregation of extracellular senile plaques composed of amyloid-beta (Aβ) in the brain. Aβ42 is the most neurotoxic and aggressive of the Aβ42 isomers released in the brain. Despite much research on AD, the complete pathophysiology of this disease remains unknown. Technical and ethical constraints place limits on experiments utilizing human subjects. Thus, animal models were used to replicate human diseases. The Drosophila melanogaster is an excellent model for studying both physiological and behavioural aspects of human neurodegenerative illnesses. Here, the negative effects of Aβ42-expression on a Drosophila AD model were investigated through three behavioural assays followed by RNA-seq. The RNA-seq data was verified using qPCR. AD Drosophila expressing human Aβ42 exhibited degenerated eye structures, shortened lifespan, and declined mobility function compared to the wild-type Control. RNA-seq revealed 1496 genes that were differentially expressed from the Aβ42-expressing samples against the control. Among the pathways that were identified from the differentially expressed genes include carbon metabolism, oxidative phosphorylation, antimicrobial peptides, and longevity-regulating pathways. While AD is a complicated neurological condition whose aetiology is influenced by a number of factors, it is hoped that the current data will be sufficient to give a general picture of how Aβ42 influences the disease pathology. The discovery of molecular connections from the current Drosophila AD model offers fresh perspectives on the usage of this Drosophila which could aid in the discovery of new anti-AD medications." @default.
• W4372318346 created "2023-05-07" @default.
• W4372318346 creator A5005124571 @default.
• W4372318346 creator A5049076363 @default.
• W4372318346 creator A5051019118 @default.
• W4372318346 creator A5086073087 @default.
• W4372318346 creator A5089823910 @default.
• W4372318346 date "2023-05-05" @default.
• W4372318346 modified "2023-09-27" @default.
• W4372318346 title "Behavioural Effects and RNA-seq Analysis of Aβ42-Mediated Toxicity in a Drosophila Alzheimer’s Disease Model" @default.
• W4372318346 cites W1223102 @default.
• W4372318346 cites W1488124756 @default.
• W4372318346 cites W1538925586 @default.
• W4372318346 cites W1749072204 @default.
• W4372318346 cites W1935951477 @default.
• W4372318346 cites W1941515972 @default.
• W4372318346 cites W1969353942 @default.
• W4372318346 cites W1971698866 @default.
• W4372318346 cites W1979369962 @default.
• W4372318346 cites W1997369314 @default.
• W4372318346 cites W1998440070 @default.
• W4372318346 cites W1998767819 @default.
• W4372318346 cites W2006780798 @default.
• W4372318346 cites W2007039381 @default.
• W4372318346 cites W2016256318 @default.
• W4372318346 cites W2018852249 @default.
• W4372318346 cites W2022268067 @default.
• W4372318346 cites W2025403964 @default.
• W4372318346 cites W2027125425 @default.
• W4372318346 cites W2034661401 @default.
• W4372318346 cites W2035963355 @default.
• W4372318346 cites W2039274569 @default.
• W4372318346 cites W2040179346 @default.
• W4372318346 cites W2049438990 @default.
• W4372318346 cites W2063296167 @default.
• W4372318346 cites W2082832824 @default.
• W4372318346 cites W2109936231 @default.
• W4372318346 cites W2121211805 @default.
• W4372318346 cites W2123060905 @default.
• W4372318346 cites W2128126778 @default.
• W4372318346 cites W2138207763 @default.
• W4372318346 cites W2146994504 @default.
• W4372318346 cites W2155858151 @default.
• W4372318346 cites W2157765869 @default.
• W4372318346 cites W2163240161 @default.
• W4372318346 cites W2169456326 @default.
• W4372318346 cites W2179438025 @default.
• W4372318346 cites W2180807141 @default.
• W4372318346 cites W2186744829 @default.
• W4372318346 cites W2210338528 @default.
• W4372318346 cites W2608871450 @default.
• W4372318346 cites W2612799687 @default.
• W4372318346 cites W2622678820 @default.
• W4372318346 cites W2797137594 @default.
• W4372318346 cites W2912165492 @default.
• W4372318346 cites W2920391004 @default.
• W4372318346 cites W2964107396 @default.
• W4372318346 cites W2974907692 @default.
• W4372318346 cites W2982165025 @default.
• W4372318346 cites W2999565373 @default.
• W4372318346 cites W3000211436 @default.
• W4372318346 cites W3029234273 @default.
• W4372318346 cites W3038625439 @default.
• W4372318346 cites W3041950789 @default.
• W4372318346 cites W3044737290 @default.
• W4372318346 cites W3090585201 @default.
• W4372318346 cites W3096575901 @default.
• W4372318346 cites W3108240332 @default.
• W4372318346 cites W3125389502 @default.
• W4372318346 cites W3157462717 @default.
• W4372318346 cites W3176378078 @default.
• W4372318346 cites W3208295396 @default.
• W4372318346 doi "https://doi.org/10.1007/s12035-023-03368-x" @default.
• W4372318346 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37145377" @default.
• W4372318346 hasPublicationYear "2023" @default.
• W4372318346 type Work @default.
• W4372318346 citedByCount "2" @default.
• W4372318346 countsByYear W43723183462023 @default.
• W4372318346 crossrefType "journal-article" @default.
• W4372318346 hasAuthorship W4372318346A5005124571 @default.
• W4372318346 hasAuthorship W4372318346A5049076363 @default.
• W4372318346 hasAuthorship W4372318346A5051019118 @default.
• W4372318346 hasAuthorship W4372318346A5086073087 @default.
• W4372318346 hasAuthorship W4372318346A5089823910 @default.
• W4372318346 hasBestOaLocation W43723183462 @default.
• W4372318346 hasConcept C104317684 @default.
• W4372318346 hasConcept C107397762 @default.
• W4372318346 hasConcept C142724271 @default.
• W4372318346 hasConcept C150194340 @default.
• W4372318346 hasConcept C162317418 @default.
• W4372318346 hasConcept C169760540 @default.
• W4372318346 hasConcept C19843653 @default.
• W4372318346 hasConcept C2776041557 @default.
• W4372318346 hasConcept C2776925932 @default.
• W4372318346 hasConcept C2777670902 @default.
• W4372318346 hasConcept C2779134260 @default.
• W4372318346 hasConcept C2780104201 @default.
• W4372318346 hasConcept C502032728 @default.

• next