FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4372329503> ?p ?o ?g. }

• W4372329503 endingPage "9" @default.
• W4372329503 startingPage "1" @default.
• W4372329503 abstract "OBJECTIVE Immunotherapy, particularly immune checkpoint inhibitors (ICIs), has revolutionized the treatment of patients with many tumor histologies. Simultaneously, stereotactic body radiotherapy (SBRT) provides excellent local control (LC) and plays an important role in the management of spine metastasis. Promising preclinical work suggests the potential therapeutic benefit of combining SBRT with ICI therapy, but the safety profile of combined therapy is unclear. This study aimed to evaluate the toxicity profile associated with ICI in patients receiving SBRT and, secondarily, whether ICI administration sequence with respect to SBRT affects LC or overall survival (OS) outcomes. METHODS The authors retrospectively reviewed patients with spine metastasis treated with SBRT at an academic center. Patients who received ICI at any point during their disease course were compared to those with the same primary tumor types who did not receive ICI by using Cox proportional hazards analyses. Primary outcomes were long-term sequelae, including radiation-induced spinal cord myelopathy, esophageal stricture, and bowel obstruction. Secondarily, models were created to evaluate OS and LC in the cohort. RESULTS Two hundred forty patients who received SBRT to 299 spine metastases were included in this study. The most common primary tumor types were non–small cell lung cancer (n = 59 [24.6%]) and renal cell carcinoma (n = 55 [22.9%]). One hundred eight patients received at least 1 dose of ICI, with the most common regimen being single-agent anti–PD-1 (n = 80 [74.1%]), followed by combination CTLA-4/PD-1 inhibitors (n = 19 [17.6%]). Three patients experienced long-term radiation-induced sequelae: 2 had esophageal stricture and 1 had bowel obstruction. No patients developed radiation-induced myelopathy. There was no association between receipt of ICI and development of any of these adverse events (p > 0.9). Similarly, ICI was not significantly associated with either LC (p = 0.3) or OS (p = 0.6). In the entire cohort, patients who received ICI prior to beginning SBRT had worse median survival, but ICI sequence with respect to SBRT was not significantly prognostic of either LC (p > 0.3) or OS (p > 0.07); instead, baseline performance status was most predictive of OS (HR 1.38, 95% CI 1.07–1.78, p = 0.012). CONCLUSIONS Treatment regimens that combine ICIs before, concurrent with, and after SBRT for spine metastases are safe, with minimal risk for increased rates of long-term toxicity." @default.
• W4372329503 created "2023-05-07" @default.
• W4372329503 creator A5000582038 @default.
• W4372329503 creator A5004050829 @default.
• W4372329503 creator A5008134271 @default.
• W4372329503 creator A5014494747 @default.
• W4372329503 creator A5018401879 @default.
• W4372329503 creator A5029218065 @default.
• W4372329503 creator A5033231728 @default.
• W4372329503 creator A5045477158 @default.
• W4372329503 creator A5054778894 @default.
• W4372329503 creator A5055100242 @default.
• W4372329503 creator A5058699710 @default.
• W4372329503 creator A5059543131 @default.
• W4372329503 creator A5062186012 @default.
• W4372329503 creator A5076246161 @default.
• W4372329503 creator A5082410046 @default.
• W4372329503 date "2023-05-01" @default.
• W4372329503 modified "2023-10-14" @default.
• W4372329503 title "Safety and clinical efficacy of immune checkpoint inhibition and stereotactic body radiotherapy in patients with spine metastasis" @default.
• W4372329503 doi "https://doi.org/10.3171/2023.3.spine221086" @default.
• W4372329503 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37148233" @default.
• W4372329503 hasPublicationYear "2023" @default.
• W4372329503 type Work @default.
• W4372329503 citedByCount "1" @default.
• W4372329503 countsByYear W43723295032023 @default.
• W4372329503 crossrefType "journal-article" @default.
• W4372329503 hasAuthorship W4372329503A5000582038 @default.
• W4372329503 hasAuthorship W4372329503A5004050829 @default.
• W4372329503 hasAuthorship W4372329503A5008134271 @default.
• W4372329503 hasAuthorship W4372329503A5014494747 @default.
• W4372329503 hasAuthorship W4372329503A5018401879 @default.
• W4372329503 hasAuthorship W4372329503A5029218065 @default.
• W4372329503 hasAuthorship W4372329503A5033231728 @default.
• W4372329503 hasAuthorship W4372329503A5045477158 @default.
• W4372329503 hasAuthorship W4372329503A5054778894 @default.
• W4372329503 hasAuthorship W4372329503A5055100242 @default.
• W4372329503 hasAuthorship W4372329503A5058699710 @default.
• W4372329503 hasAuthorship W4372329503A5059543131 @default.
• W4372329503 hasAuthorship W4372329503A5062186012 @default.
• W4372329503 hasAuthorship W4372329503A5076246161 @default.
• W4372329503 hasAuthorship W4372329503A5082410046 @default.
• W4372329503 hasConcept C118552586 @default.
• W4372329503 hasConcept C121608353 @default.
• W4372329503 hasConcept C126322002 @default.
• W4372329503 hasConcept C126838900 @default.
• W4372329503 hasConcept C143998085 @default.
• W4372329503 hasConcept C2777604421 @default.
• W4372329503 hasConcept C2778164965 @default.
• W4372329503 hasConcept C2779013556 @default.
• W4372329503 hasConcept C2780387249 @default.
• W4372329503 hasConcept C2780775167 @default.
• W4372329503 hasConcept C509974204 @default.
• W4372329503 hasConcept C71924100 @default.
• W4372329503 hasConceptScore W4372329503C118552586 @default.
• W4372329503 hasConceptScore W4372329503C121608353 @default.
• W4372329503 hasConceptScore W4372329503C126322002 @default.
• W4372329503 hasConceptScore W4372329503C126838900 @default.
• W4372329503 hasConceptScore W4372329503C143998085 @default.
• W4372329503 hasConceptScore W4372329503C2777604421 @default.
• W4372329503 hasConceptScore W4372329503C2778164965 @default.
• W4372329503 hasConceptScore W4372329503C2779013556 @default.
• W4372329503 hasConceptScore W4372329503C2780387249 @default.
• W4372329503 hasConceptScore W4372329503C2780775167 @default.
• W4372329503 hasConceptScore W4372329503C509974204 @default.
• W4372329503 hasConceptScore W4372329503C71924100 @default.
• W4372329503 hasLocation W43723295031 @default.
• W4372329503 hasLocation W43723295032 @default.
• W4372329503 hasOpenAccess W4372329503 @default.
• W4372329503 hasPrimaryLocation W43723295031 @default.
• W4372329503 hasRelatedWork W1997983519 @default.
• W4372329503 hasRelatedWork W2017442716 @default.
• W4372329503 hasRelatedWork W2163132578 @default.
• W4372329503 hasRelatedWork W2332734736 @default.
• W4372329503 hasRelatedWork W2388910868 @default.
• W4372329503 hasRelatedWork W2914514705 @default.
• W4372329503 hasRelatedWork W3011073888 @default.
• W4372329503 hasRelatedWork W3031853862 @default.
• W4372329503 hasRelatedWork W3093597142 @default.
• W4372329503 hasRelatedWork W3200865426 @default.
• W4372329503 isParatext "false" @default.
• W4372329503 isRetracted "false" @default.
• W4372329503 workType "article" @default.